| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Da Vinci Code | - | - | - | $22,337,569 | 752 | $34,543,406 | May 19 | Sony Pictures Releasing | false |
| 2 | Mission: Impossible III | - | - | - | $8,224,814 | 529 | $9,190,665 | May 5 | United International Pictures | false |
| 3 | X-Men: The Last Stand | - | - | - | $5,841,097 | 454 | $12,315,946 | May 26 | 20th Century Fox International | false |
| 4 | Inside Man | - | - | - | $2,466,169 | 256 | $7,821,983 | Apr 12 | United International Pictures | false |
| 5 | Eight Below | - | - | - | $2,251,127 | 225 | $3,360,543 | Apr 28 | Buena Vista International | false |
| 6 | Take the Lead | - | - | - | $2,073,944 | 260 | $3,066,028 | Apr 28 | TriPictures | false |
| 7 | Ice Age 2: The Meltdown | - | - | - | $2,046,436 | 451 | $24,248,139 | Mar 31 | 20th Century Fox International | false |
| 8 | Failure to Launch | - | - | - | $1,588,491 | 222 | $3,806,731 | Apr 21 | United International Pictures | false |
| 9 | Chaos | - | - | - | $1,568,404 | 169 | $1,795,554 | May 12 | TriPictures | false |
| 10 | Bee Season | - | - | - | $1,508,481 | 225 | $2,342,463 | Apr 28 | 20th Century Fox International | false |
| 11 | Volver | - | - | - | $1,394,468 | 239 | $12,241,181 | Mar 17 | Warner Bros. | false |
| 12 | Crossing Borders | - | - | - | $1,334,872 | 198 | $1,630,859 | May 5 | Alta Films | false |
| 13 | The Wild | - | - | - | $1,111,205 | 382 | $5,305,708 | Apr 12 | Buena Vista International | false |
| 14 | Lucky Number Slevin | - | - | - | $947,313 | 405 | $4,535,108 | Apr 7 | TriPictures | false |
| 15 | Hard Candy | - | - | - | $762,297 | 84 | $860,120 | May 12 | Aurum Films | false |
| 16 | V for Vendetta | - | - | - | $542,559 | 302 | $5,435,193 | Apr 7 | Warner Bros. | false |
| 17 | Yours, Mine & Ours | - | - | - | $414,435 | 100 | $1,778,306 | Apr 12 | Sony Pictures Releasing | false |
| 18 | Nanny McPhee | - | - | - | $411,678 | 229 | $2,730,090 | Apr 7 | United International Pictures | false |
| 19 | 16 Blocks | - | - | - | $355,399 | 240 | $2,362,372 | Apr 12 | Filmax | false |
| 20 | Imagine Me & You | - | - | - | $300,827 | 69 | $300,827 | May 5 | TriPictures | false |
| 21 | Slither | - | - | - | $286,563 | 80 | $319,667 | May 12 | United International Pictures | false |
| 22 | On Probation | - | - | - | $283,641 | 94 | $1,026,514 | May 26 | - | false |
| 23 | The Beat That My Heart Skipped 2005 Re-release | - | - | - | $222,451 | 33 | $330,672 | Apr 28 | Vértigo Films | false |
| 24 | Ask the Dust | - | - | - | $220,274 | 57 | $220,274 | May 12 | Filmax | false |
| 25 | Dark Blue Almost Black | - | - | - | $200,657 | 67 | $931,354 | Mar 31 | Alta Films | false |
| 26 | The World's Fastest Indian | - | - | - | $188,651 | 157 | $196,084 | May 12 | Alta Films | false |
| 27 | Crash | - | - | - | $185,801 | 176 | $10,270,180 | Jan 13 | Manga Entertainment | false |
| 28 | Welcome Home | - | - | - | $157,382 | 150 | $1,565,855 | Apr 7 | 20th Century Fox International | false |
| 29 | Cake | - | - | - | $146,886 | 59 | $146,886 | May 19 | Flins & Piniculas | false |
| 30 | Rosario Tijeras | - | - | - | $119,713 | 80 | $178,157 | May 26 | Manga Entertainment | false |
| 31 | Factotum | - | - | - | $45,873 | 22 | $45,873 | May 26 | Golem Distribución | false |
| 32 | The Road to Guantanamo | - | - | - | $38,975 | 33 | $38,975 | May 26 | Alta Films | false |
| 33 | What the #$*! Do We (K)now!? 2005 Re-release | - | - | - | $29,364 | 15 | $646,626 | May 5 | Karma Films | false |
| 34 | Water Canadian Release | - | - | - | $23,340 | 21 | $1,339,332 | Mar 3 | Golem Distribución | false |
| 35 | Viva Cuba | - | - | - | $21,064 | 35 | $51,731 | May 26 | - | false |
| 36 | Beneath Still Waters | - | - | - | $18,001 | 20 | $18,001 | May 26 | Filmax | false |
| 37 | The Good Voice | - | - | - | $16,326 | 25 | $16,326 | May 26 | - | false |
| 38 | You Are So Beautiful | - | - | - | $14,439 | 76 | $448,048 | Apr 21 | On Pictures | false |
| 39 | Stoned | - | - | - | $12,042 | 27 | $12,402 | May 26 | - | false |
| 40 | Stay | - | - | - | $10,439 | 23 | $130,672 | May 12 | 20th Century Fox International | false |
| 41 | The Wretched Life of Juanita Narboni | - | - | - | $8,981 | 11 | $35,321 | May 19 | Wanda Visión S.A. | false |
| 42 | North Country | - | - | - | $6,518 | 34 | $396,154 | Mar 31 | Warner Bros. | false |
| 43 | Shanghai Dreams | - | - | - | $6,071 | 5 | $6,071 | May 26 | - | false |
| 44 | Himalaya 2006 Re-release | - | - | - | $5,770 | 14 | $238,629 | Apr 12 | Karma Films | false |
| 45 | Freedomland | - | - | - | $5,615 | 9 | $173,563 | Apr 28 | Sony Pictures Releasing | false |
| 46 | Free Zone | - | - | - | $5,445 | 11 | $135,798 | Apr 28 | Golem Distribución | false |
| 47 | La gran final | - | - | - | $5,263 | 5 | $191,659 | Apr 21 | Wanda Visión S.A. | false |
| 48 | On the Line 2006 Re-release | - | - | - | $4,456 | 9 | $141,582 | Apr 28 | Laurenfilm | false |
| 49 | The Libertine | - | - | - | $4,002 | 62 | $388,265 | Apr 12 | Aurum Films | false |
| 50 | Remake | - | - | - | $3,998 | 67 | $339,560 | Apr 21 | Warner Bros. | false |
| 51 | Rock & Cat | - | - | - | $3,788 | 4 | $83,115 | Apr 21 | Filmax | false |
| 52 | La semana que viene (sin falta) | - | - | - | $3,318 | 164 | $409,773 | Mar 3 | DeAPlaneta | false |
| 53 | The Three Burials of Melquiades Estrada | - | - | - | $3,094 | 105 | $812,026 | Feb 17 | Alta Films | false |
| 54 | The Maidens' Conspiracy | - | - | - | $2,935 | 261 | $1,917,353 | Apr 7 | DeAPlaneta | false |
| 55 | One Missed Call 2 | - | - | - | $2,923 | 71 | $521,941 | Apr 7 | United International Pictures | false |
| 56 | Good Night, and Good Luck. | - | - | - | $2,077 | 118 | $4,329,211 | Feb 10 | Manga Entertainment | false |
| 57 | Zathura: A Space Adventure | - | - | - | $1,361 | 225 | $2,340,597 | Mar 10 | Sony Pictures Releasing | false |
| 58 | Transamerica | - | - | - | $1,338 | 2 | $539,289 | - | - | false |
| 59 | The Bow | - | - | - | $1,169 | 4 | $177,567 | Mar 31 | Golem Distribución | false |
| 60 | Estrellas de La Línea | - | - | - | $833 | 10 | $38,729 | May 12 | Buena Vista International | false |
| 61 | Heights | - | - | - | $723 | 3 | $77,889 | Apr 28 | Sony Pictures Releasing | false |
| 62 | El triunfo | - | - | - | $704 | 99 | $248,335 | Apr 28 | Filmax | false |
| 63 | Little Sky 2006 Re-release | - | - | - | $675 | 2 | $45,929 | Apr 21 | Sagrera TV | false |
| 64 | Terre Promise | - | - | - | $597 | 1 | $6,216 | May 19 | United International Pictures | false |
| 65 | Capote | - | - | - | $575 | 107 | $2,058,336 | Feb 24 | Sony Pictures Releasing | false |
| 66 | Hostel | - | - | - | $555 | 250 | $2,220,513 | Mar 24 | Sony Pictures Releasing | false |
| 67 | Caché | - | - | - | $550 | 38 | $830,950 | Jan 20 | Golem Distribución | false |
| 68 | El mundo alrededor | - | - | - | $497 | 4 | $17,383 | May 12 | Premium Film | false |
| 69 | Memoirs of a Geisha | - | - | - | $181 | 240 | $14,289,365 | Jan 20 | Sony Pictures Releasing | false |
| 70 | Fun with Dick and Jane | - | - | - | $11 | 317 | $4,472,511 | Feb 10 | Sony Pictures Releasing | false |
