| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | The Da Vinci Code | - | - | - | $20,641,716 | 561 | $6,530,042 | 31.6% | 561 | May 18 | - | United International Pictures | false |
| 2 | X-Men: The Last Stand | - | - | - | $12,601,706 | 408 | $5,063,912 | 40.2% | 408 | May 25 | - | 20th Century Fox International | false |
| 3 | Mission: Impossible III | - | - | - | $8,446,854 | 451 | $2,932,587 | 34.7% | 449 | May 4 | - | United International Pictures | false |
| 4 | Take the Lead | - | - | - | $4,939,371 | 129 | $1,064,092 | 21.5% | 128 | May 25 | - | Roadshow Films | false |
| 5 | The Benchwarmers | - | - | - | $1,969,253 | 184 | $592,161 | 30.1% | 184 | May 11 | - | Sony Pictures Releasing | false |
| 6 | Candy | - | - | - | $1,084,873 | 44 | $202,598 | 18.7% | 38 | May 25 | - | Dendy Films | false |
| 7 | Separate Lies | - | - | - | $971,322 | 36 | $120,150 | 12.4% | 36 | May 25 | - | 20th Century Fox International | false |
| 8 | Caché | - | - | - | $790,448 | 15 | $117,761 | 14.9% | 12 | May 4 | - | Dendy Films | false |
| 9 | The Three Burials of Melquiades Estrada | - | - | - | $533,114 | 37 | $90,643 | 17% | 36 | May 25 | - | Madman Entertainment | false |
| 10 | Two for the Money | - | - | - | $407,352 | 105 | $203,534 | 50% | 105 | May 11 | - | United International Pictures | false |
| 11 | Slither | - | - | - | $338,320 | 114 | $173,594 | 51.3% | 114 | May 18 | - | United International Pictures | false |
| 12 | Dave Chappelle's Block Party | - | - | - | $222,799 | 13 | $71,835 | 32.2% | 12 | May 4 | - | Hopscotch Films | false |
| 13 | Higher Ground | - | - | - | $199,892 | 3 | $81,423 | 40.7% | 2 | May 25 | - | Warren Miller Entertainment | false |
| 14 | Ballets Russes | - | - | - | $189,452 | 11 | - | - | - | May 18 | - | Hopscotch Films | false |
| 15 | Fanaa | - | - | - | $187,187 | 9 | $94,704 | 50.6% | 9 | May 25 | - | MG Distribution | false |
| 16 | Where the Truth Lies | - | - | - | $178,526 | 12 | $61,033 | 34.2% | 12 | May 11 | - | Roadshow Films | false |
| 17 | Last Holiday | - | - | - | $157,588 | 60 | $80,006 | 50.8% | 60 | May 25 | - | United International Pictures | false |
| 18 | On a Clear Day | - | - | - | $125,411 | 14 | $50,850 | 40.5% | 14 | May 11 | - | Icon Film Distribution Australia | false |
| 19 | The New World 2005 Re-release | - | - | - | $122,321 | 41 | $49,621 | 40.6% | 41 | May 4 | - | Roadshow Films | false |
| 20 | Neil Young: Heart of Gold | - | - | - | $93,270 | - | - | - | - | May 12 | - | - | false |
| 21 | Glory Road | - | - | - | $2,878 | - | - | - | - | May 4 | - | - | false |
