| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Kingdom of Heaven | - | - | - | $8,426,139 | 616 | $9,522,276 | May 6 | Medusa Distribuzione | false |
| 2 | Star Wars: Episode III - Revenge of the Sith | - | - | - | $6,581,440 | 624 | $11,301,748 | May 20 | 20th Century Fox International | false |
| 3 | Once You're Born You Can No Longer Hide | - | - | - | $1,380,391 | 234 | $1,670,856 | May 13 | 01 Distribution | false |
| 4 | L'uomo perfetto | - | - | - | $1,344,314 | 142 | $1,881,273 | Apr 29 | Warner Bros. | false |
| 5 | Downfall | - | - | - | $1,289,280 | 122 | $1,719,541 | Apr 29 | 01 Distribution | false |
| 6 | Head in the Clouds | - | - | - | $1,225,897 | 242 | $1,972,835 | Apr 29 | Moviemax | false |
| 7 | The Final Cut | - | - | - | $1,164,742 | 187 | $1,164,742 | May 13 | Eagle Pictures | false |
| 8 | Modigliani | - | - | - | $918,235 | 238 | $1,009,517 | May 13 | Istituto Luce | false |
| 9 | The Pacifier | - | - | - | $814,971 | 200 | $3,072,938 | Apr 22 | Buena Vista International | false |
| 10 | Sahara | - | - | - | $711,306 | 200 | $3,325,503 | Apr 22 | United International Pictures | false |
| 11 | xXx: State of the Union | - | - | - | $582,706 | 244 | $1,029,910 | Apr 29 | Sony Pictures Releasing | false |
| 12 | Oldboy | - | - | - | $434,207 | 68 | $434,207 | May 6 | Lucky Red | false |
| 13 | Quo Vadis, Baby? | - | - | - | $413,891 | 252 | $2,358,579 | May 27 | Medusa Distribuzione | false |
| 14 | Cellular | - | - | - | $381,349 | 226 | $697,707 | Apr 29 | Eagle Pictures | false |
| 15 | Miss Congeniality 2: Armed & Fabulous | - | - | - | $350,837 | 121 | $350,837 | May 6 | Warner Bros. | false |
| 16 | Have No Fear | - | - | - | $308,227 | 126 | $308,227 | May 6 | Italian International Film | false |
| 17 | Kung Fu Hustle | - | - | - | $300,551 | 153 | $1,134,402 | May 27 | Sony Pictures Releasing | false |
| 18 | The Consequences of Love | - | - | - | $296,997 | 75 | $1,774,472 | Sep 24 | Medusa Distribuzione | false |
| 19 | White Noise | - | - | - | $281,648 | 138 | $1,134,387 | May 27 | United International Pictures | false |
| 20 | Be Cool | - | - | - | $242,811 | 271 | $3,169,572 | Apr 15 | 20th Century Fox International | false |
| 21 | Last Days | - | - | - | $235,234 | 66 | $235,234 | May 13 | BIM Distribuzione | false |
| 22 | Stage Beauty | - | - | - | $212,131 | 59 | $212,131 | May 6 | Mikado Film | false |
| 23 | House of Wax | - | - | - | $198,129 | 171 | $849,547 | May 27 | Warner Bros. | false |
| 24 | The Wedding Date | - | - | - | $190,344 | 114 | $326,697 | Apr 29 | Medusa Distribuzione | false |
| 25 | Only Human | - | - | - | $181,189 | 91 | $181,229 | May 20 | Italian International Film | false |
| 26 | Hipnos | - | - | - | $172,583 | 69 | $172,583 | May 6 | DNC Entertainment | false |
| 27 | Il ritorno del Monnezza | - | - | - | $102,263 | 271 | $3,273,446 | Apr 15 | Medusa Distribuzione | false |
| 28 | La febbre | - | - | - | $92,706 | 249 | $3,813,551 | Apr 1 | 01 Distribution | false |
| 29 | Sorry, You Can't Get Through! | - | - | - | $61,571 | 94 | $61,571 | May 20 | Moviemax | false |
| 30 | Camp 2005 Re-release | - | - | - | $55,442 | 145 | $55,442 | May 27 | Eagle Pictures | false |
| 31 | L'orizzonte degli eventi | - | - | - | $34,193 | 42 | $139,771 | May 20 | Medusa Distribuzione | false |
| 32 | Red Lights | - | - | - | $32,432 | 19 | $32,432 | May 6 | BIM Distribuzione | false |
| 33 | Brodeuses: A Common Thread | - | - | - | $30,349 | 20 | $399,994 | May 27 | BIM Distribuzione | false |
| 34 | Fatti della banda della Magliana | - | - | - | $27,181 | 13 | $27,181 | May 27 | Istituto Luce | false |
| 35 | Loverboy | - | - | - | $20,234 | 34 | $20,234 | May 20 | Warner Bros. | false |
| 36 | The Story of the Weeping Camel | - | - | - | $18,339 | 26 | $287,244 | May 27 | Fandango | false |
