| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Shutter Island | - | - | - | $133,084 | 5 | $190,246 | Mar 11 | United International Pictures | false |
| 2 | Leap Year | - | - | - | $126,539 | 8 | $163,068 | Mar 4 | United International Pictures | false |
| 3 | Alice in Wonderland | - | - | - | $115,526 | 8 | $171,221 | Mar 4 | Walt Disney Pictures | false |
| 4 | Valentine's Day | - | - | - | $61,341 | 9 | $246,792 | Feb 18 | Warner Bros. | false |
| 5 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $48,082 | 13 | $576,300 | Jan 28 | 20th Century Fox International | false |
| 6 | The Wolfman | - | - | - | $41,581 | 7 | $127,464 | Feb 18 | United International Pictures | false |
| 7 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $33,841 | 8 | $47,562 | Mar 11 | 20th Century Fox International | false |
| 8 | Green Zone | - | - | - | $33,428 | 6 | $58,433 | Mar 18 | United International Pictures | false |
| 9 | Invictus | - | - | - | $27,875 | 5 | $44,070 | Feb 25 | Warner Bros. | false |
| 10 | Cloudy with a Chance of Meatballs | - | - | - | $24,125 | 13 | $73,067 | Feb 11 | Sony Pictures Releasing | false |
| 11 | Nine | - | - | - | $21,702 | 4 | $48,920 | Mar 4 | - | false |
| 12 | The Hurt Locker | - | - | - | $21,696 | 2 | $39,408 | Feb 18 | - | false |
| 13 | Avatar | - | - | - | $17,496 | 18 | $1,917,323 | Dec 17 | 20th Century Fox International | false |
| 14 | Legion | - | - | - | $15,476 | 5 | $29,471 | Feb 25 | Sony Pictures Releasing | false |
| 15 | The Lovely Bones | - | - | - | $5,424 | 5 | $13,243 | Feb 25 | United International Pictures | false |
| 16 | Did You Hear About the Morgans? | - | - | - | $5,161 | 8 | $117,342 | Feb 4 | Sony Pictures Releasing | false |
| 17 | The Men Who Stare at Goats | - | - | - | $4,673 | 4 | $74,580 | Jan 28 | - | false |
| 18 | Everybody's Fine | - | - | - | $4,300 | 2 | $5,156 | Mar 11 | Walt Disney Pictures | false |
| 19 | The Princess and the Frog | - | - | - | $3,479 | 9 | $115,260 | Jan 21 | Walt Disney Pictures | false |
| 20 | Edge of Darkness | - | - | - | $3,016 | 4 | $27,536 | Feb 11 | - | false |
| 21 | An Education | - | - | - | $2,846 | 2 | $9,492 | Feb 18 | - | false |
