| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $2,961,479 | 97 | $3,136,113 | Mar 4 | Walt Disney Pictures | false |
| 2 | Miss You Like Crazy | - | - | - | $1,666,920 | 85 | $3,183,529 | Feb 24 | Star Cinema | false |
| 3 | How to Train Your Dragon | - | - | - | $765,690 | 91 | $1,390,310 | Mar 19 | United International Pictures | false |
| 4 | The Book of Eli | - | - | - | $367,922 | 30 | $528,495 | Mar 17 | Sony Pictures Releasing | false |
| 5 | Green Zone | - | - | - | $309,562 | 31 | $385,808 | Mar 12 | United International Pictures | false |
| 6 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $292,056 | 71 | $2,056,265 | Feb 12 | 20th Century Fox International | false |
| 7 | Cop Out | - | - | - | $256,849 | 50 | $258,672 | Mar 3 | Warner Bros. | false |
| 8 | Remember Me | - | - | - | $204,561 | 45 | $210,317 | Mar 12 | Pioneer Films | false |
| 9 | When in Rome | - | - | - | $164,814 | 50 | $172,561 | Mar 17 | Walt Disney Pictures | false |
| 10 | Avatar | - | - | - | $115,747 | 105 | $5,956,400 | Dec 17 | 20th Century Fox International | false |
| 11 | Extraordinary Measures | - | - | - | $108,155 | 40 | $109,091 | Mar 10 | Sony Pictures Releasing | false |
| 12 | The Fourth Kind | - | - | - | $103,329 | 20 | $103,329 | Mar 3 | Viva International Pictures | false |
| 13 | From Paris with Love | - | - | - | $96,963 | 30 | $196,856 | Feb 24 | Viva International Pictures | false |
| 14 | The Wolfman | - | - | - | $93,349 | 53 | $596,321 | Feb 12 | United International Pictures | false |
| 15 | Up in the Air | - | - | - | $81,588 | 12 | $81,875 | Mar 3 | United International Pictures | false |
| 16 | The Road | - | - | - | $64,708 | 16 | $64,708 | Mar 3 | Pioneer Films | false |
| 17 | Valentine's Day | - | - | - | $55,064 | 50 | $752,679 | Feb 12 | Warner Bros. | false |
| 18 | I Love You Phillip Morris | - | - | - | $50,918 | 14 | $85,853 | Mar 24 | Pioneer Films | false |
| 19 | Armored | - | - | - | $34,686 | 50 | $106,158 | Feb 24 | Sony Pictures Releasing | false |
| 20 | Invictus | - | - | - | $22,432 | 16 | $78,787 | Feb 17 | Warner Bros. | false |
| 21 | It's Complicated | - | - | - | $20,253 | 16 | $88,652 | Feb 24 | United International Pictures | false |
| 22 | Dear John | - | - | - | $10,884 | 18 | $455,383 | Feb 5 | Pioneer Films | false |
| 23 | Infestation | - | - | - | $9,971 | 17 | $36,756 | Feb 24 | Pioneer Films | false |
| 24 | Cirque du Freak: The Vampire's Assistant | - | - | - | $9,314 | 20 | $254,860 | Jan 27 | United International Pictures | false |
| 25 | Cloudy with a Chance of Meatballs | - | - | - | $7,301 | 73 | $268,315 | Jan 27 | Sony Pictures Releasing | false |
| 26 | Tooth Fairy | - | - | - | $5,466 | 50 | $472,939 | Jan 22 | 20th Century Fox International | false |
| 27 | Crazy Heart | - | - | - | $4,033 | 1 | $4,033 | Mar 3 | 20th Century Fox International | false |
| 28 | Case 39 | - | - | - | $4,015 | 12 | $66,838 | Feb 3 | United International Pictures | false |
| 29 | The Princess and the Frog | - | - | - | $3,658 | 50 | $284,188 | Feb 3 | Walt Disney Pictures | false |
| 30 | Messengers 2: The Scarecrow | - | - | - | $2,438 | 3 | $131,497 | Feb 3 | Viva International Pictures | false |
| 31 | Legion | - | - | - | $1,950 | 50 | $1,136,978 | Jan 22 | Sony Pictures Releasing | false |
| 32 | Couples Retreat | - | - | - | $1,184 | 9 | $12,982 | Feb 17 | United International Pictures | false |
