| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $5,378,956 | 172 | $8,910,059 | Mar 10 | Walt Disney Pictures | false |
| 2 | Avatar | - | - | - | $1,560,163 | 150 | $26,874,162 | Dec 17 | 20th Century Fox International | false |
| 3 | Dear John | - | - | - | $1,234,821 | 82 | $1,871,191 | Mar 11 | A-Film Distribution | false |
| 4 | Shutter Island | - | - | - | $1,188,523 | 52 | $2,632,442 | Feb 18 | Universal Pictures International (UPI) | false |
| 5 | The Book of Eli | - | - | - | $847,931 | 55 | $1,012,045 | Mar 4 | Paradiso Entertainment | false |
| 6 | From Paris with Love | - | - | - | $571,407 | 70 | $951,185 | Mar 18 | Entertainment One | false |
| 7 | Cloudy with a Chance of Meatballs | - | - | - | $550,328 | 85 | $2,447,098 | Feb 17 | Sony Pictures Releasing | false |
| 8 | Gangsterboys | - | - | - | $495,022 | 39 | $1,441,099 | Feb 18 | Independent Films | false |
| 9 | Valentine's Day | - | - | - | $465,286 | 106 | $3,320,832 | Feb 11 | Warner Bros. | false |
| 10 | Eep! 2010 Re-release | - | - | - | $438,043 | 90 | $1,713,357 | Feb 18 | Independent Films | false |
| 11 | The Lovely Bones | - | - | - | $434,050 | 54 | $760,157 | Feb 25 | Universal Pictures International (UPI) | false |
| 12 | Invictus | - | - | - | $365,406 | 28 | $411,567 | Mar 4 | Warner Bros. | false |
| 13 | The Princess and the Frog | - | - | - | $339,797 | 137 | $3,057,126 | Feb 4 | Walt Disney Pictures | false |
| 14 | Chloe | - | - | - | $304,658 | 39 | $321,784 | Mar 4 | Universal Pictures International (UPI) | false |
| 15 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $294,872 | 96 | $1,923,665 | Feb 11 | Warner Bros. | false |
| 16 | A Single Man | - | - | - | $260,323 | 20 | $891,594 | Feb 4 | Cinéart | false |
| 17 | Nanny McPhee Returns | - | - | - | $228,579 | 99 | $1,530,287 | Mar 25 | Universal Pictures International (UPI) | false |
| 18 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $222,389 | 37 | $250,905 | Mar 11 | Benelux Film Distributors | false |
| 19 | The Girl Who Kicked the Hornet's Nest | - | - | - | $193,114 | 40 | $750,282 | Mar 25 | Benelux Film Distributors | false |
| 20 | Case 39 | - | - | - | $147,034 | 20 | $249,482 | Mar 18 | Universal Pictures International (UPI) | false |
| 21 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $125,221 | 119 | $7,077,813 | Dec 21 | Warner Bros. | false |
| 22 | A Prophet | - | - | - | $110,999 | 26 | $463,100 | Feb 4 | Cinemien | false |
| 23 | The Girl Who Played with Fire | - | - | - | $110,901 | 58 | $1,072,278 | Jan 21 | Benelux Film Distributors | false |
| 24 | First Mission | - | - | - | $105,538 | 59 | $288,968 | Mar 25 | A-Film Distribution | false |
| 25 | Solomon Kane | - | - | - | $98,395 | 20 | $175,286 | Mar 25 | Entertainment One | false |
| 26 | The Road | - | - | - | $78,533 | 17 | $86,803 | Mar 18 | Benelux Film Distributors | false |
| 27 | The Wolfman | - | - | - | $75,376 | 56 | $713,685 | Feb 11 | Universal Pictures International (UPI) | false |
| 28 | Love Life | - | - | - | $45,972 | 125 | $12,514,413 | Nov 26 | Benelux Film Distributors | false |
| 29 | Edge of Darkness | - | - | - | $36,268 | 78 | $1,140,932 | Jan 28 | Entertainment One | false |
| 30 | The Hurt Locker | - | - | - | $32,326 | 12 | $85,813 | Feb 11 | Independent Films | false |
| 31 | The Last Station 2010 Re-release | - | - | - | $30,870 | 22 | $103,806 | Mar 4 | Entertainment One | false |
| 32 | Two Eyes Staring | - | - | - | $26,804 | 26 | $26,804 | Mar 11 | - | false |
| 33 | Gainsbourg: A Heroic Life | - | - | - | $18,909 | 12 | $18,909 | Mar 18 | - | false |
| 34 | Lebanon | - | - | - | $17,323 | 16 | $17,323 | Mar 18 | - | false |
| 35 | Crazy Heart | - | - | - | $10,318 | 5 | $10,318 | Mar 25 | Warner Bros. | false |
| 36 | Escaping Tel Aviv | - | - | - | $9,017 | 3 | $9,017 | Mar 18 | - | false |
| 37 | Lourdes | - | - | - | $8,719 | 11 | $8,719 | Mar 11 | - | false |
| 38 | The Messenger | - | - | - | $4,117 | 3 | $4,117 | Mar 25 | Entertainment One | false |
| 39 | Bloody Fox | - | - | - | $1,713 | 3 | $1,713 | Mar 11 | - | false |
| 40 | Videocracy | - | - | - | $1,256 | 3 | $1,256 | Mar 11 | - | false |
| 41 | Great Kills Road | - | - | - | $481 | 3 | $481 | Mar 11 | - | false |
