| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $27,841,871 | 781 | $31,347,734 | Mar 5 | Walt Disney Pictures | false |
| 2 | How to Train Your Dragon | - | - | - | $5,458,940 | 852 | $14,362,388 | Mar 26 | Paramount Pictures International | false |
| 3 | Shutter Island | - | - | - | $3,025,122 | 300 | $4,286,629 | Mar 12 | Paramount Pictures International | false |
| 4 | Edge of Darkness | - | - | - | $2,904,713 | 354 | $4,070,888 | Feb 26 | Warner Bros. | false |
| 5 | The Blind Side | - | - | - | $2,506,301 | 347 | $4,105,623 | Mar 19 | Warner Bros. | false |
| 6 | The Wolfman | - | - | - | $2,241,841 | 698 | $11,144,027 | Feb 12 | Universal Pictures International (UPI) | false |
| 7 | The Lovely Bones | - | - | - | $1,293,073 | 352 | $2,898,173 | Feb 19 | Paramount Pictures International | false |
| 8 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $1,275,847 | 700 | $6,024,219 | Feb 12 | 20th Century Fox International | false |
| 9 | The Bounty Hunter | - | - | - | $1,239,621 | 301 | $2,942,253 | Mar 26 | Sony Pictures Releasing | false |
| 10 | Legion | - | - | - | $1,041,459 | 175 | $2,403,289 | Mar 19 | Sony Pictures Releasing | false |
| 11 | Avatar | - | - | - | $1,026,357 | 1,138 | $43,763,643 | Dec 17 | 20th Century Fox International | false |
| 12 | The Spy Next Door 2010 Re-release | - | - | - | $805,990 | 240 | $1,434,014 | Mar 19 | Gussi Films | false |
| 13 | The Book of Eli | - | - | - | $750,068 | 300 | $4,043,777 | Jan 29 | Sony Pictures Releasing | false |
| 14 | The Hurt Locker | - | - | - | $686,684 | 67 | $1,114,807 | Feb 12 | Gussi Films | false |
| 15 | Messengers 2: The Scarecrow | - | - | - | $677,566 | 199 | $1,128,303 | Feb 26 | Videocine | false |
| 16 | Precious | - | - | - | $598,714 | 40 | $859,206 | Mar 5 | Gussi Films | false |
| 17 | Valentine's Day | - | - | - | $554,640 | 350 | $3,278,718 | Feb 12 | Warner Bros. | false |
| 18 | Remember Me | - | - | - | $545,873 | 205 | $1,082,812 | Mar 26 | - | false |
| 19 | Love Happens | - | - | - | $459,106 | 180 | $786,953 | Feb 26 | - | false |
| 20 | Daybreakers | - | - | - | $424,306 | 230 | $1,041,994 | Feb 19 | Gussi Films | false |
| 21 | Extraordinary Measures | - | - | - | $400,472 | 100 | $791,466 | Mar 12 | Sony Pictures Releasing | false |
| 22 | The Fourth Kind | - | - | - | $345,729 | 225 | $2,577,037 | Jan 22 | Gussi Films | false |
| 23 | Armored | - | - | - | $329,268 | 80 | $791,603 | Feb 5 | Sony Pictures Releasing | false |
| 24 | The Young Victoria | - | - | - | $303,254 | 39 | $422,340 | Mar 12 | - | false |
| 25 | The Children | - | - | - | $286,098 | 70 | $391,797 | Mar 5 | - | false |
| 26 | Nine | - | - | - | $284,140 | 40 | $591,879 | Feb 26 | Sony Pictures Releasing | false |
| 27 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $255,924 | 102 | $571,409 | Feb 5 | Gussi Films | false |
| 28 | Rock Marí | - | - | - | $242,474 | 245 | $315,909 | Mar 12 | Videocine | false |
| 29 | It's Complicated | - | - | - | $223,438 | 350 | $3,497,634 | Jan 29 | Universal Pictures International (UPI) | false |
| 30 | Tooth Fairy | - | - | - | $199,893 | 500 | $7,890,387 | Jan 15 | 20th Century Fox International | false |
| 31 | One for the Road | - | - | - | $199,340 | 110 | $281,426 | Mar 19 | - | false |
| 32 | The Haunting of Molly Hartley | - | - | - | $183,742 | 98 | $326,515 | Mar 19 | - | false |
| 33 | Invictus | - | - | - | $158,354 | 201 | $2,238,624 | Jan 22 | Warner Bros. | false |
| 34 | Mongol: The Rise of Genghis Khan | - | - | - | $137,224 | 35 | $294,573 | Feb 5 | - | false |
| 35 | Possession | - | - | - | $134,740 | 70 | $241,816 | Mar 12 | Gussi Films | false |
| 36 | Crazy Heart | - | - | - | $116,399 | 28 | $181,973 | Feb 26 | 20th Century Fox International | false |
| 37 | When in Rome | - | - | - | $115,263 | 203 | $647,611 | Feb 5 | Walt Disney Pictures | false |
| 38 | Regresa | - | - | - | $105,337 | 230 | $1,396,505 | Jan 22 | - | false |
| 39 | An Education | - | - | - | $92,121 | 15 | $274,549 | Feb 19 | Sony Pictures Releasing | false |
| 40 | Miss Conception 2010 Re-release | - | - | - | $88,003 | 35 | $131,666 | Mar 5 | - | false |
| 41 | Coming Soon | - | - | - | $86,398 | 20 | $166,606 | Mar 19 | - | false |
| 42 | Franklyn | - | - | - | $78,354 | 100 | $234,744 | Feb 5 | - | false |
| 43 | Motherhood | - | - | - | $68,992 | 40 | $188,480 | Jan 29 | Gussi Films | false |
| 44 | Up in the Air | - | - | - | $58,707 | 251 | $2,176,272 | Jan 22 | Paramount Pictures International | false |
| 45 | Astro Boy | - | - | - | $50,125 | 149 | $710,349 | Jan 29 | - | false |
| 46 | Boogie | - | - | - | $49,834 | 92 | $61,011 | Mar 5 | - | false |
| 47 | Did You Hear About the Morgans? | - | - | - | $35,957 | 216 | $1,739,167 | Jan 15 | Sony Pictures Releasing | false |
| 48 | Departures | - | - | - | $33,050 | 20 | $159,238 | Jan 29 | - | false |
| 49 | Battle for Terra | - | - | - | $28,066 | 52 | $241,313 | Feb 19 | Gussi Films | false |
| 50 | LOL (Laughing Out Loud) | - | - | - | $27,849 | 14 | $60,068 | Mar 26 | - | false |
| 51 | Ricky | - | - | - | $24,210 | 13 | $27,003 | Mar 19 | - | false |
| 52 | A Serious Man | - | - | - | $22,763 | 15 | $137,186 | Jan 29 | Universal Pictures International (UPI) | false |
| 53 | Ninja Assassin | - | - | - | $22,242 | 120 | $430,480 | Jan 15 | Warner Bros. | false |
| 54 | AAA, la película: Sin límite en el tiempo | - | - | - | $18,332 | 226 | $557,931 | Jan 22 | Videocine | false |
| 55 | Fame | - | - | - | $17,989 | 151 | $275,939 | Jan 15 | - | false |
| 56 | Hadewijch | - | - | - | $17,170 | 5 | $21,503 | Mar 5 | - | false |
| 57 | Mujer alabastrina | - | - | - | $11,776 | 108 | $135,251 | Feb 19 | - | false |
| 58 | Pandorum | - | - | - | $9,604 | 100 | $285,967 | Jan 15 | Gussi Films | false |
| 59 | The Baader Meinhof Complex | - | - | - | $8,843 | 2 | $17,040 | Feb 12 | - | false |
| 60 | Where in the World Is Osama Bin Laden? 2010 Re-release | - | - | - | $5,506 | 9 | $5,816 | Mar 26 | - | false |
| 61 | Easy Virtue | - | - | - | $4,416 | 10 | $87,402 | Dec 4 | Sony Pictures Releasing | false |
| 62 | What My Eyes Have Seen 2010 Re-release | - | - | - | $3,712 | 10 | $25,048 | Feb 19 | - | false |
| 63 | The Milk of Sorrow | - | - | - | $2,746 | 10 | $52,630 | Jan 15 | - | false |
| 64 | Redención | - | - | - | $2,085 | 4 | $2,165 | Mar 26 | - | false |
