| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $34,729,780 | 668 | $39,952,697 | Mar 3 | Walt Disney Pictures | false |
| 2 | Shutter Island | - | - | - | $8,582,835 | 433 | $9,434,156 | Mar 5 | Medusa Distribuzione | false |
| 3 | Loose Cannons | - | - | - | $8,581,584 | 427 | $10,994,715 | Mar 12 | 01 Distribution | false |
| 4 | Genitori & figli:) - Agitare bene prima dell'uso | - | - | - | $7,408,471 | 471 | $11,455,266 | Feb 26 | Filmauro | false |
| 5 | Invictus | - | - | - | $5,554,399 | 418 | $9,063,387 | Feb 26 | Warner Bros. | false |
| 6 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $3,854,484 | 288 | $4,139,909 | Mar 12 | 20th Century Fox International | false |
| 7 | It's Complicated | - | - | - | $3,725,908 | 302 | $4,985,582 | Mar 19 | United International Pictures | false |
| 8 | Avatar | - | - | - | $3,184,533 | 856 | $93,746,295 | Jan 15 | 20th Century Fox International | false |
| 9 | How to Train Your Dragon | - | - | - | $2,672,482 | 488 | $6,505,999 | Mar 26 | Universal Pictures International (UPI) | false |
| 10 | Happy Family | - | - | - | $2,217,530 | 353 | $6,111,219 | Mar 26 | 01 Distribution | false |
| 11 | The Book of Eli | - | - | - | $2,110,023 | 331 | $3,916,301 | Feb 26 | 01 Distribution | false |
| 12 | Valentine's Day | - | - | - | $1,846,603 | 295 | $1,846,603 | Mar 12 | Warner Bros. | false |
| 13 | Remember Me | - | - | - | $1,710,661 | 335 | $3,008,966 | Mar 26 | Eagle Pictures | false |
| 14 | Edge of Darkness | - | - | - | $1,616,481 | 272 | $1,820,221 | Mar 19 | 01 Distribution | false |
| 15 | The Concert | - | - | - | $1,209,378 | 139 | $4,825,505 | Feb 5 | BIM Distribuzione | false |
| 16 | Tutto l'amore del mondo | - | - | - | $1,183,296 | 268 | $1,192,420 | Mar 19 | Medusa Distribuzione | false |
| 17 | The Wolfman | - | - | - | $1,075,457 | 391 | $5,937,460 | Feb 19 | United International Pictures | false |
| 18 | Legion | - | - | - | $720,946 | 125 | $810,426 | Mar 12 | Sony Pictures Releasing | false |
| 19 | La valigia sul letto | - | - | - | $597,023 | 85 | $763,063 | Mar 12 | Medusa Distribuzione | false |
| 20 | Daybreakers | - | - | - | $534,297 | 146 | $770,682 | Mar 26 | Sony Pictures Releasing | false |
| 21 | A Prophet | - | - | - | $518,955 | 81 | $794,872 | Mar 19 | BIM Distribuzione | false |
| 22 | Did You Hear About the Morgans? | - | - | - | $486,851 | 232 | $2,561,420 | Feb 19 | Sony Pictures Releasing | false |
| 23 | The Youngest Son | - | - | - | $471,791 | 320 | $2,848,577 | Feb 19 | Medusa Distribuzione | false |
| 24 | Leaving | - | - | - | $354,470 | 43 | $410,506 | Mar 5 | Teodora Film | false |
| 25 | Chloe | - | - | - | $348,325 | 87 | $416,579 | Mar 12 | Eagle Pictures | false |
| 26 | Women Without Men | - | - | - | $317,467 | 33 | $368,804 | Mar 12 | BIM Distribuzione | false |
| 27 | Sorry If I Want to Marry You | - | - | - | $290,443 | 492 | $9,217,837 | Feb 12 | Medusa Distribuzione | false |
| 28 | Cloudy with a Chance of Meatballs | - | - | - | $267,693 | 308 | $6,448,099 | Dec 23 | Sony Pictures Releasing | false |
| 29 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $233,549 | 344 | $8,197,134 | Jan 29 | 20th Century Fox International | false |
| 30 | I Am Love | - | - | - | $202,738 | 42 | $284,612 | Mar 19 | Mikado Film | false |
| 31 | The Man Who Will Come | - | - | - | $154,560 | 69 | $1,877,452 | Jan 22 | Mikado Film | false |
| 32 | The First Beautiful Thing | - | - | - | $132,843 | 350 | $9,115,665 | Jan 15 | Medusa Distribuzione | false |
| 33 | Lilly the Witch: The Dragon and the Magic Book | - | - | - | $120,399 | 155 | $1,226,230 | Feb 12 | Walt Disney Pictures | false |
| 34 | Le missionnaire | - | - | - | $91,929 | 173 | $1,072,505 | Feb 19 | Eagle Pictures | false |
| 35 | Crazy Heart | - | - | - | $80,114 | 10 | $158,110 | Mar 5 | 20th Century Fox International | false |
| 36 | The Mouth of the Wolf | - | - | - | $78,773 | 17 | $179,376 | Feb 19 | BIM Distribuzione | false |
| 37 | Up in the Air | - | - | - | $73,335 | 339 | $7,439,717 | Jan 22 | United International Pictures | false |
| 38 | Incendiary | - | - | - | $70,586 | 9 | $143,379 | Feb 26 | - | false |
| 39 | Revanche | - | - | - | $64,694 | 20 | $64,694 | Mar 5 | Fandango | false |
| 40 | Diamond 13 | - | - | - | $59,550 | 6 | $121,631 | Mar 5 | - | false |
| 41 | An Education | - | - | - | $59,401 | 37 | $536,758 | Feb 5 | Sony Pictures Releasing | false |
| 42 | A Single Man | - | - | - | $44,532 | 56 | $1,531,617 | Jan 15 | - | false |
| 43 | The Hurt Locker | - | - | - | $43,964 | 70 | $234,231 | Oct 10 | Warner Bros. | false |
| 44 | Lourdes | - | - | - | $42,805 | 83 | $510,877 | Feb 11 | - | false |
| 45 | North | - | - | - | $42,489 | 12 | $105,216 | Feb 26 | Sacher Distribuzione | false |
| 46 | Soul Kitchen | - | - | - | $22,449 | 100 | $2,371,166 | Jan 8 | BIM Distribuzione | false |
| 47 | The Lovely Bones | - | - | - | $14,449 | 332 | $2,396,608 | Feb 12 | United International Pictures | false |
| 48 | Call of the Wild | - | - | - | $8,874 | 62 | $206,094 | Feb 19 | - | false |
