| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $1,896,002 | 70 | $2,047,959 | Mar 4 | Walt Disney Pictures | false |
| 2 | How to Train Your Dragon | - | - | - | $848,070 | 68 | $1,560,733 | Mar 26 | United International Pictures | false |
| 3 | Green Zone | - | - | - | $794,476 | 44 | $1,032,116 | Mar 12 | United International Pictures | false |
| 4 | Shutter Island | - | - | - | $492,078 | 34 | $772,735 | Mar 3 | United International Pictures | false |
| 5 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $291,093 | 58 | $1,554,109 | Feb 10 | 20th Century Fox International | false |
| 6 | The Wolfman | - | - | - | $262,635 | 63 | $1,101,085 | Feb 17 | United International Pictures | false |
| 7 | Avatar | - | - | - | $257,613 | 87 | $5,809,653 | Dec 17 | 20th Century Fox International | false |
| 8 | It's Complicated | - | - | - | $106,874 | 23 | $115,818 | Mar 24 | United International Pictures | false |
| 9 | Up in the Air | - | - | - | $76,024 | 13 | $154,220 | Feb 24 | United International Pictures | false |
| 10 | Sherlock Holmes | - | - | - | $64,879 | 45 | $2,163,216 | Dec 30 | Warner Bros. | false |
| 11 | Ninja Assassin | - | - | - | $53,217 | 50 | $1,862,728 | Nov 26 | Warner Bros. | false |
| 12 | Legion | - | - | - | $23,870 | 35 | $723,331 | Jan 27 | Sony Pictures Releasing | false |
| 13 | Valentine's Day | - | - | - | $19,383 | 33 | $428,149 | Feb 11 | Warner Bros. | false |
| 14 | Case 39 | - | - | - | $6,106 | 13 | $119,057 | Jan 27 | United International Pictures | false |
