| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $242,418 | 14 | $336,719 | Mar 4 | Walt Disney Pictures | false |
| 2 | Shutter Island | - | - | - | $177,009 | 9 | $254,410 | Mar 11 | United International Pictures | false |
| 3 | Avatar | - | - | - | $102,693 | 21 | $2,029,219 | Dec 17 | 20th Century Fox International | false |
| 4 | The Blind Side | - | - | - | $77,777 | 6 | $95,404 | Mar 4 | Warner Bros. | false |
| 5 | The Wolfman | - | - | - | $51,558 | 9 | $145,585 | Feb 18 | United International Pictures | false |
| 6 | From Paris with Love | - | - | - | $49,790 | 6 | $89,792 | Mar 18 | - | false |
| 7 | Cloudy with a Chance of Meatballs | - | - | - | $49,527 | 16 | $151,058 | Feb 4 | Sony Pictures Releasing | false |
| 8 | The Spy Next Door 2010 Re-release | - | - | - | $45,932 | 5 | $74,826 | Feb 25 | - | false |
| 9 | The Lovely Bones | - | - | - | $40,849 | 7 | $58,794 | Feb 25 | United International Pictures | false |
| 10 | Leap Year | - | - | - | $38,272 | 6 | $67,344 | Mar 18 | United International Pictures | false |
| 11 | Dear John | - | - | - | $37,151 | 6 | $99,856 | Feb 18 | - | false |
| 12 | Remember Me | - | - | - | $35,517 | 9 | $108,751 | Mar 25 | - | false |
| 13 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $30,639 | 6 | $41,723 | Mar 18 | 20th Century Fox International | false |
| 14 | Invictus 2010 Re-release | - | - | - | $27,480 | 6 | $29,059 | Mar 11 | Warner Bros. | false |
| 15 | Edge of Darkness | - | - | - | $26,010 | 5 | $47,334 | Feb 25 | - | false |
| 16 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $24,922 | 8 | $83,991 | Feb 11 | 20th Century Fox International | false |
| 17 | Up in the Air | - | - | - | $20,191 | 7 | $139,985 | Feb 4 | United International Pictures | false |
| 18 | It's Complicated | - | - | - | $16,213 | 7 | $179,181 | Jan 28 | United International Pictures | false |
| 19 | Valentine's Day | - | - | - | $14,960 | 10 | $155,753 | Feb 11 | Warner Bros. | false |
| 20 | Crazy Heart | - | - | - | $3,349 | 1 | $4,864 | Mar 18 | 20th Century Fox International | false |
| 21 | Hachi: A Dog's Tale | - | - | - | $1,807 | 1 | $5,413 | Feb 18 | - | false |
