| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $55,752,985 | 533 | $64,437,055 | Mar 5 | Walt Disney Pictures | false |
| 2 | Shutter Island | - | - | - | $12,859,746 | 419 | $16,304,568 | Mar 12 | Paramount Pictures International | false |
| 3 | Green Zone | - | - | - | $7,999,817 | 419 | $8,259,161 | Mar 12 | Universal Pictures International (UPI) | false |
| 4 | The Bounty Hunter | - | - | - | $7,048,506 | 394 | $8,998,455 | Mar 19 | Sony Pictures Releasing | false |
| 5 | Nanny McPhee Returns | - | - | - | $6,922,746 | 529 | $23,571,491 | Mar 26 | Universal Pictures International (UPI) | false |
| 6 | Avatar | - | - | - | $6,494,220 | 503 | $147,646,580 | Dec 18 | 20th Century Fox International | false |
| 7 | The Blind Side | - | - | - | $3,649,662 | 371 | $9,127,125 | Mar 26 | Warner Bros. | false |
| 8 | The Lovely Bones | - | - | - | $3,435,590 | 425 | $9,301,424 | Feb 19 | Paramount Pictures International | false |
| 9 | I Love You Phillip Morris | - | - | - | $3,324,647 | 342 | $3,496,127 | Mar 19 | Entertainment One | false |
| 10 | The Crazies | - | - | - | $3,068,927 | 348 | $4,889,087 | Feb 26 | Paramount Pictures International | false |
| 11 | The Spy Next Door 2010 Re-release | - | - | - | $2,310,161 | 332 | $3,971,159 | Mar 19 | Paramount Pictures International | false |
| 12 | The Girl with the Dragon Tattoo | - | - | - | $2,163,366 | 126 | $2,342,433 | Mar 12 | Momentum Pictures | false |
| 13 | Leap Year | - | - | - | $1,630,727 | 331 | $2,740,697 | Feb 26 | Optimum Releasing | false |
| 14 | From Paris with Love | - | - | - | $1,574,378 | 280 | $2,609,205 | Feb 26 | Warner Bros. | false |
| 15 | Hachi: A Dog's Tale | - | - | - | $1,563,107 | 316 | $1,563,107 | Mar 12 | Entertainment Film Distributors | false |
| 16 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $1,260,874 | 472 | $11,035,357 | Feb 12 | 20th Century Fox International | false |
| 17 | Valentine's Day | - | - | - | $1,239,828 | 436 | $15,460,467 | Feb 12 | Warner Bros. | false |
| 18 | The Princess and the Frog | - | - | - | $1,167,662 | 503 | $16,387,133 | Feb 12 | Walt Disney Pictures | false |
| 19 | A Single Man | - | - | - | $1,063,356 | 105 | $4,035,997 | Feb 12 | Icon Film Distribution Australia | false |
| 20 | Crazy Heart | - | - | - | $1,050,713 | 123 | $1,479,176 | Feb 19 | 20th Century Fox International | false |
| 21 | Shank | - | - | - | $608,915 | 86 | $713,697 | Mar 26 | Revolver Entertainment | false |
| 22 | Invictus | - | - | - | $431,016 | 279 | $6,870,705 | Feb 5 | Warner Bros. | false |
| 23 | Legion | - | - | - | $321,524 | 135 | $321,524 | Mar 5 | Sony Pictures Releasing | false |
| 24 | Case 39 | - | - | - | $277,246 | 151 | $277,246 | Oct 2 | Paramount Pictures International | false |
| 25 | Chloe | - | - | - | $205,245 | 114 | $417,634 | Mar 5 | Optimum Releasing | false |
| 26 | Old Dogs | - | - | - | $195,822 | 205 | $195,822 | - | Walt Disney Pictures | false |
| 27 | Perrier's Bounty | - | - | - | $160,430 | 90 | $160,430 | Mar 26 | Optimum Releasing | false |
| 28 | Lourdes | - | - | - | $58,882 | 18 | $58,882 | Mar 26 | Artificial Eye | false |
