| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $600,185 | 124 | $10,818,765 | Dec 17 | 20th Century Fox International | false |
| 2 | How to Train Your Dragon | - | - | - | $350,141 | 69 | $1,511,998 | Mar 25 | United International Pictures | false |
| 3 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $287,161 | 50 | $803,087 | Feb 11 | 20th Century Fox International | false |
| 4 | The Wolfman | - | - | - | $248,647 | 44 | $762,258 | Feb 11 | United International Pictures | false |
| 5 | The Hurt Locker | - | - | - | $234,040 | 21 | $348,664 | Feb 18 | - | false |
| 6 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $179,391 | 54 | $1,424,935 | Jan 28 | 20th Century Fox International | false |
| 7 | Legion | - | - | - | $155,894 | 26 | $444,893 | Mar 25 | Sony Pictures Releasing | false |
| 8 | The Lovely Bones | - | - | - | $132,947 | 33 | $276,533 | Feb 18 | United International Pictures | false |
| 9 | 500 Days of Summer | - | - | - | $85,327 | 8 | $132,235 | Mar 11 | 20th Century Fox International | false |
| 10 | Valentine's Day | - | - | - | $67,652 | 32 | $320,998 | Feb 11 | Warner Bros. | false |
| 11 | [Rec]² | - | - | - | $65,476 | 16 | $96,032 | Mar 18 | - | false |
| 12 | The Blind Side | - | - | - | $58,838 | 8 | $96,354 | Mar 18 | Warner Bros. | false |
| 13 | Halloween II | - | - | - | $56,870 | 16 | $63,966 | Mar 11 | - | false |
| 14 | Sherlock Holmes | - | - | - | $51,104 | 65 | $1,263,442 | Jan 21 | Warner Bros. | false |
| 15 | My Best Friend's Girl | - | - | - | $49,681 | 15 | $59,152 | Mar 18 | Transeuropa | false |
| 16 | The Haunting in Connecticut | - | - | - | $45,193 | 13 | $214,186 | Jan 14 | Transeuropa | false |
| 17 | Precious | - | - | - | $40,845 | 4 | $45,371 | Feb 25 | - | false |
| 18 | Couples Retreat | - | - | - | $38,147 | 14 | $46,735 | Feb 25 | United International Pictures | false |
| 19 | The Box | - | - | - | $33,017 | 18 | $55,749 | Mar 25 | - | false |
| 20 | Ponyo | - | - | - | $31,313 | 8 | $36,353 | Feb 25 | Andes Films | false |
| 21 | Welcome to the Sticks | - | - | - | $26,097 | 6 | $17,543 | Mar 11 | - | false |
| 22 | Everybody's Fine | - | - | - | $24,111 | 8 | $32,530 | Feb 25 | Walt Disney Pictures | false |
| 23 | Invictus | - | - | - | $18,706 | 20 | $203,487 | Feb 4 | Warner Bros. | false |
| 24 | Up in the Air | - | - | - | $18,482 | 21 | $151,820 | Feb 4 | United International Pictures | false |
| 25 | It's Complicated | - | - | - | $18,316 | 29 | $243,953 | Jan 28 | United International Pictures | false |
| 26 | Nine | - | - | - | $15,854 | 12 | $51,640 | Feb 18 | Sony Pictures Releasing | false |
| 27 | Let the Right One In | - | - | - | $12,156 | 5 | $54,580 | Mar 25 | - | false |
| 28 | Toy Story 2009 Re-release | - | - | - | $11,544 | 13 | $36,299 | Feb 18 | Walt Disney Pictures | false |
| 29 | Toy Story 2 2009 Re-release | - | - | - | $10,928 | 13 | $44,163 | Feb 18 | Walt Disney Pictures | false |
| 30 | The Imaginarium of Doctor Parnassus | - | - | - | $8,621 | 6 | $90,374 | Jan 28 | Sony Pictures Releasing | false |
| 31 | Tooth Fairy | - | - | - | $7,218 | 38 | $526,596 | Jan 7 | 20th Century Fox International | false |
| 32 | Astro Boy | - | - | - | $6,695 | 27 | $188,580 | Jan 21 | - | false |
| 33 | Saw VI | - | - | - | $5,779 | 27 | $174,417 | Jan 21 | Walt Disney Pictures | false |
| 34 | Old Dogs | - | - | - | $3,149 | 30 | $360,864 | Dec 24 | Walt Disney Pictures | false |
| 35 | My Stars | - | - | - | $2,353 | 4 | $4,459 | Mar 18 | - | false |
| 36 | Planet 51 | - | - | - | $1,876 | 24 | $271,297 | Nov 26 | - | false |
| 37 | Ninja Assassin | - | - | - | $1,698 | 23 | $93,442 | Jan 28 | Warner Bros. | false |
| 38 | Igor | - | - | - | $1,581 | 14 | $21,892 | Feb 11 | - | false |
| 39 | An Education | - | - | - | $1,026 | 5 | $27,571 | Jan 21 | Sony Pictures Releasing | false |
