| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $546,139 | 13 | $676,994 | Mar 4 | Walt Disney Pictures | false |
| 2 | Avatar | - | - | - | $59,258 | 18 | $1,454,156 | Dec 17 | 20th Century Fox International | false |
| 3 | How to Train Your Dragon | - | - | - | $58,940 | 13 | $282,504 | Mar 25 | Paramount Pictures International | false |
| 4 | The Hurt Locker | - | - | - | $48,016 | 2 | $72,208 | Feb 18 | Trade International | false |
| 5 | The Book of Eli | - | - | - | $47,841 | 6 | $84,676 | Mar 18 | Sony Pictures Releasing | false |
| 6 | The Wolfman | - | - | - | $37,450 | 12 | $142,291 | Feb 11 | Universal Pictures International (UPI) | false |
| 7 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $37,191 | 12 | $121,320 | Feb 11 | 20th Century Fox International | false |
| 8 | Edge of Darkness | - | - | - | $30,504 | 7 | $45,517 | Feb 25 | Warner Bros. | false |
| 9 | The Blind Side | - | - | - | $24,547 | 5 | $35,097 | Mar 18 | Warner Bros. | false |
| 10 | Old Dogs | - | - | - | $21,647 | 5 | $137,191 | Jan 28 | Walt Disney Pictures | false |
| 11 | Cirque du Freak: The Vampire's Assistant | - | - | - | $20,824 | 7 | $20,824 | Mar 11 | Universal Pictures International (UPI) | false |
| 12 | Did You Hear About the Morgans? | - | - | - | $19,375 | 4 | $19,375 | Mar 11 | Sony Pictures Releasing | false |
| 13 | Paranormal Activity | - | - | - | $14,147 | 4 | $71,293 | Mar 25 | - | false |
| 14 | Up in the Air | - | - | - | $14,100 | 8 | $14,100 | Mar 4 | Paramount Pictures International | false |
| 15 | Tooth Fairy | - | - | - | $10,536 | 8 | $174,809 | Jan 14 | 20th Century Fox International | false |
| 16 | All About Steve | - | - | - | $9,975 | 4 | $18,159 | Feb 25 | 20th Century Fox International | false |
| 17 | The Imaginarium of Doctor Parnassus | - | - | - | $8,857 | 4 | $19,019 | Mar 25 | Sony Pictures Releasing | false |
| 18 | Sorority Row | - | - | - | $5,294 | 6 | $12,324 | Feb 25 | Manfer Films | false |
| 19 | Couples Retreat | - | - | - | $4,510 | 4 | $9,736 | Feb 25 | Universal Pictures International (UPI) | false |
| 20 | Valentine's Day | - | - | - | $4,398 | 5 | $45,439 | Feb 11 | Warner Bros. | false |
| 21 | Invictus | - | - | - | $3,687 | 4 | $33,539 | Feb 4 | Warner Bros. | false |
| 22 | Everybody's Fine | - | - | - | $3,012 | 2 | $6,703 | Mar 18 | Walt Disney Pictures | false |
| 23 | Sherlock Holmes | - | - | - | $2,706 | 7 | $133,079 | Jan 14 | Warner Bros. | false |
| 24 | Bordertown 2010 Re-release | - | - | - | $2,628 | 2 | $2,628 | Mar 11 | Trade International | false |
| 25 | Cowards 2010 Re-release | - | - | - | $1,049 | 2 | $1,049 | Mar 25 | - | false |
| 26 | An Education | - | - | - | $1,043 | 2 | $1,448 | Mar 25 | Sony Pictures Releasing | false |
