| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $3,767,071 | 118 | $6,245,391 | Mar 10 | Walt Disney Pictures | false |
| 2 | Shutter Island | - | - | - | $1,786,323 | 46 | $3,000,673 | Feb 24 | Universal Pictures International (UPI) | false |
| 3 | Avatar | - | - | - | $598,136 | 196 | $15,866,546 | Dec 16 | 20th Century Fox International | false |
| 4 | The Round Up | - | - | - | $521,594 | 24 | $761,473 | Mar 10 | Belga Films | false |
| 5 | Bo | - | - | - | $476,149 | 23 | $1,524,017 | Feb 10 | Kinepolis Film Distribution (KFD) | false |
| 6 | The Princess and the Frog | - | - | - | $403,996 | 81 | $3,235,435 | Feb 3 | Walt Disney Pictures | false |
| 7 | The Pimp | - | - | - | $338,691 | 18 | $817,722 | Feb 17 | Belga Films | false |
| 8 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $315,490 | 80 | $2,090,477 | Feb 10 | 20th Century Fox International | false |
| 9 | From Paris with Love | - | - | - | $274,734 | 33 | $452,140 | Feb 24 | Belga Films | false |
| 10 | Valentine's Day | - | - | - | $256,118 | 48 | $1,583,712 | Feb 10 | 20th Century Fox International | false |
| 11 | A Single Man | - | - | - | $249,770 | 12 | $397,654 | Feb 24 | Cinéart | false |
| 12 | The Ghost Writer | - | - | - | $242,645 | 34 | $933,211 | Mar 24 | Benelux Film Distributors | false |
| 13 | Precious | - | - | - | $232,562 | 16 | $275,195 | Mar 3 | A-Film Distribution | false |
| 14 | Edge of Darkness | - | - | - | $223,208 | 44 | $716,475 | Feb 17 | Kinepolis Film Distribution (KFD) | false |
| 15 | Case 39 | - | - | - | $211,440 | 24 | $377,753 | Mar 17 | Universal Pictures International (UPI) | false |
| 16 | Chloe | - | - | - | $201,742 | 21 | $222,515 | Mar 10 | Universal Pictures International (UPI) | false |
| 17 | Planet 51 | - | - | - | $150,817 | 61 | $862,786 | Feb 10 | Belga Films | false |
| 18 | Nine | - | - | - | $148,391 | 30 | $189,416 | Mar 3 | Paradiso Entertainment | false |
| 19 | 22 Bullets | - | - | - | $143,675 | 16 | $435,451 | Mar 24 | Belga Films | false |
| 20 | Wolf 2010 Re-release | - | - | - | $136,459 | 23 | $553,170 | Mar 24 | Kinepolis Film Distribution (KFD) | false |
| 21 | The Wolfman | - | - | - | $119,370 | 36 | $1,104,657 | Feb 10 | Universal Pictures International (UPI) | false |
| 22 | Coursier | - | - | - | $114,399 | 16 | $115,203 | Mar 3 | Belga Films | false |
| 23 | I Love You Phillip Morris | - | - | - | $111,913 | 27 | $393,388 | Feb 17 | Belga Films | false |
| 24 | Desert Flower 2009 Re-release | - | - | - | $94,957 | 13 | $212,918 | Mar 17 | Cinéart | false |
| 25 | The Hurt Locker | - | - | - | $85,987 | 16 | $315,133 | Sep 23 | Belga Films | false |
| 26 | An Education | - | - | - | $70,685 | 8 | $107,283 | Feb 24 | Kinepolis Film Distribution (KFD) | false |
| 27 | Heartbreaker | - | - | - | $66,435 | 23 | $143,573 | Mar 17 | - | false |
| 28 | Oceans | - | - | - | $66,265 | 26 | $732,605 | Jan 27 | Alternative Films | false |
| 29 | All That Glitters | - | - | - | $63,175 | 12 | $186,936 | Mar 24 | Alternative Films | false |
| 30 | Crazy Heart | - | - | - | $56,412 | 5 | $61,738 | Mar 3 | 20th Century Fox International | false |
| 31 | Cloudy with a Chance of Meatballs | - | - | - | $55,808 | 42 | $1,122,314 | Jan 13 | Sony Pictures Releasing | false |
| 32 | The Imaginarium of Doctor Parnassus | - | - | - | $51,115 | 16 | $371,963 | Feb 10 | Kinepolis Film Distribution (KFD) | false |
| 33 | Pièce montée | - | - | - | $49,215 | 10 | $49,215 | Mar 10 | Alternative Films | false |
| 34 | The Men Who Stare at Goats | - | - | - | $42,705 | 14 | $327,273 | Jan 6 | Kinepolis Film Distribution (KFD) | false |
| 35 | A Serious Man | - | - | - | $42,238 | 13 | $489,273 | Jan 20 | Universal Pictures International (UPI) | false |
| 36 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $34,246 | 93 | $4,461,871 | Dec 23 | 20th Century Fox International | false |
| 37 | Gainsbourg: A Heroic Life | - | - | - | $34,121 | 21 | $462,434 | Feb 3 | Cinéart | false |
| 38 | The Lovely Bones | - | - | - | $33,011 | 33 | $498,758 | Feb 10 | Universal Pictures International (UPI) | false |
| 39 | Dumas | - | - | - | $25,799 | 8 | $41,298 | Mar 17 | Benelux Film Distributors | false |
| 40 | White as Snow | - | - | - | $22,696 | 8 | $27,530 | Mar 17 | Benelux Film Distributors | false |
| 41 | Mr. Nobody | - | - | - | $20,385 | 36 | $816,771 | Jan 13 | Belga Films | false |
| 42 | Together Is Too Much | - | - | - | $20,352 | 8 | $39,540 | Mar 3 | Cinéart | false |
| 43 | The Book of Eli | - | - | - | $20,073 | 32 | $574,030 | Feb 3 | Paradiso Entertainment | false |
| 44 | The Boat Race | - | - | - | $18,906 | 6 | $37,657 | Feb 24 | Cinéart | false |
| 45 | Thelma, Louise et Chantal | - | - | - | $18,570 | 4 | $19,888 | Mar 3 | Les Films de l'Elysée | false |
| 46 | Up in the Air | - | - | - | $18,303 | 26 | $1,113,452 | Jan 20 | Universal Pictures International (UPI) | false |
| 47 | Fantastic Mr. Fox | - | - | - | $18,004 | 17 | $78,578 | Feb 17 | 20th Century Fox International | false |
| 48 | Devil's Kickers | - | - | - | $15,015 | 3 | $21,403 | Mar 10 | Universal Pictures International (UPI) | false |
| 49 | Tales from the Golden Age 2009 Re-release | - | - | - | $14,755 | 7 | $16,058 | Mar 3 | - | false |
| 50 | Mary and Max | - | - | - | $12,787 | 3 | $18,078 | Feb 24 | Kinepolis Film Distribution (KFD) | false |
| 51 | Vincere | - | - | - | $11,710 | 8 | $82,225 | Feb 10 | ABC Distribution | false |
| 52 | Invictus | - | - | - | $11,000 | 25 | $738,223 | Jan 13 | Warner Bros. | false |
| 53 | Lebanon | - | - | - | $7,644 | 7 | $7,644 | Mar 17 | ABC Distribution | false |
| 54 | Everybody's Fine | - | - | - | $7,477 | 5 | $14,611 | Mar 17 | Walt Disney Pictures | false |
| 55 | Silent Voice | - | - | - | $6,334 | 4 | $21,147 | Feb 17 | Cinéart | false |
| 56 | Did You Hear About the Morgans? | - | - | - | $5,536 | 27 | $756,459 | Jan 27 | Sony Pictures Releasing | false |
| 57 | Pope Joan | - | - | - | $5,442 | 5 | $5,442 | Mar 10 | Kinepolis Film Distribution (KFD) | false |
| 58 | No One Knows About Persian Cats | - | - | - | $5,136 | 6 | $56,739 | Jan 27 | Cinéart | false |
| 59 | The Girl Who Played with Fire | - | - | - | $3,960 | 21 | $196,087 | Jan 13 | Benelux Film Distributors | false |
| 60 | The Road | - | - | - | $2,373 | 24 | $367,861 | Jan 27 | Benelux Film Distributors | false |
| 61 | First Mission | - | - | - | $2,183 | 2 | $2,183 | Mar 24 | Kinepolis Film Distribution (KFD) | false |
| 62 | Katalin Varga | - | - | - | $1,281 | 1 | $2,461 | Feb 24 | Benelux Film Distributors | false |
| 63 | OceanWorld | - | - | - | $1,104 | 15 | $71,727 | Feb 10 | - | false |
| 64 | Dossier K. | - | - | - | $642 | 38 | $3,647,079 | Dec 9 | Kinepolis Film Distribution (KFD) | false |
| 65 | Henri-Georges Clouzot's Inferno | - | - | - | $613 | 2 | $613 | Mar 10 | ABC Distribution | false |
| 66 | Toys in the Attic 2010 Re-release | - | - | - | $568 | 3 | $568 | Mar 24 | - | false |
| 67 | Persécution | - | - | - | $454 | 2 | $454 | Mar 3 | - | false |
| 68 | The Indian | - | - | - | $77 | 1 | $77 | Mar 3 | Jekino | false |
| 69 | Tempo of a Restless Soul | - | - | - | $47 | 2 | $290 | Mar 17 | - | false |
