| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | La matassa | - | - | - | $8,852,116 | 514 | $10,007,765 | Mar 13 | Medusa Distribuzione | false |
| 2 | Gran Torino | - | - | - | $7,501,202 | 332 | $12,993,866 | Mar 13 | Warner Bros. | false |
| 3 | Confessions of a Shopaholic | - | - | - | $3,962,861 | 369 | $6,192,300 | Feb 27 | Walt Disney Pictures | false |
| 4 | Watchmen | - | - | - | $3,628,771 | 344 | $3,721,232 | Mar 6 | Universal Pictures International (UPI) | false |
| 5 | Different from Whom | - | - | - | $3,032,952 | 364 | $4,602,897 | Mar 20 | United International Pictures | false |
| 6 | The Curious Case of Benjamin Button | - | - | - | $3,023,561 | 502 | $15,750,900 | Feb 13 | Warner Bros. | false |
| 7 | He's Just Not That Into You | - | - | - | $2,746,929 | 323 | $3,508,807 | Mar 20 | 01 Distribution | false |
| 8 | The Wrestler | - | - | - | $2,726,704 | 315 | $2,824,964 | Mar 6 | Lucky Red | false |
| 9 | Slumdog Millionaire | - | - | - | $2,449,060 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
| 10 | Ex | - | - | - | $2,217,375 | 571 | $15,340,865 | Feb 6 | 01 Distribution | false |
| 11 | Due partite | - | - | - | $1,952,366 | 210 | $2,027,829 | Mar 6 | 01 Distribution | false |
| 12 | The Unborn | - | - | - | $1,487,958 | 179 | $2,470,810 | Feb 27 | Universal Pictures International (UPI) | false |
| 13 | Iago | - | - | - | $1,452,002 | 378 | $2,678,424 | Feb 27 | Medusa Distribuzione | false |
| 14 | Italians | - | - | - | $1,449,036 | 611 | $17,026,331 | Jan 23 | Filmauro | false |
| 15 | The Reader | - | - | - | $1,430,082 | 161 | $3,645,596 | Feb 20 | 01 Distribution | false |
| 16 | The New Monsters Today | - | - | - | $1,416,596 | 406 | $2,486,257 | Mar 27 | Warner Bros. | false |
| 17 | The Pink Panther 2 | - | - | - | $1,338,854 | 198 | $1,284,973 | Mar 6 | Sony Pictures Releasing | false |
| 18 | The International | - | - | - | $1,173,432 | 170 | $1,375,443 | Mar 20 | Sony Pictures Releasing | false |
| 19 | Push | - | - | - | $957,979 | 197 | $1,902,080 | Mar 27 | Eagle Pictures | false |
| 20 | Inkheart | - | - | - | $869,211 | 269 | $3,289,477 | Feb 20 | Eagle Pictures | false |
| 21 | Australia | - | - | - | $825,429 | 485 | $7,351,155 | Jan 16 | 20th Century Fox International | false |
| 22 | Journey to the Center of the Earth | - | - | - | $750,231 | 276 | $11,724,131 | Jan 16 | 01 Distribution | false |
| 23 | Ponyo | - | - | - | $737,601 | 184 | $1,013,560 | Mar 20 | Lucky Red | false |
| 24 | Mesrine: Killer Instinct | - | - | - | $704,920 | 178 | $704,920 | Mar 13 | Eagle Pictures | false |
| 25 | Giulia Doesn't Date at Night | - | - | - | $653,480 | 179 | $1,118,316 | Feb 27 | 01 Distribution | false |
| 26 | The Case of Unfaithful Klara | - | - | - | $621,216 | 262 | $991,709 | Mar 27 | Medusa Distribuzione | false |
| 27 | Live! | - | - | - | $570,304 | 74 | $570,304 | Mar 6 | Moviemax | false |
| 28 | Eden Is West | - | - | - | $537,816 | 179 | $550,811 | Mar 6 | Medusa Distribuzione | false |
| 29 | Bedtime Stories | - | - | - | $502,583 | 87 | $899,750 | Mar 27 | Walt Disney Pictures | false |
| 30 | Fort Apache Napoli | - | - | - | $436,551 | 112 | $785,422 | Mar 27 | 01 Distribution | false |
| 31 | The Wave | - | - | - | $405,200 | 57 | $696,752 | Feb 27 | BIM Distribuzione | false |
| 32 | Milk | - | - | - | $388,527 | 174 | $3,202,523 | Jan 23 | BIM Distribuzione | false |
| 33 | Valkyrie | - | - | - | $382,993 | 394 | $6,094,571 | Jan 30 | 01 Distribution | false |
| 34 | Underworld: Rise of the Lycans | - | - | - | $371,930 | 119 | $1,592,463 | Feb 20 | Sony Pictures Releasing | false |
| 35 | Revolutionary Road | - | - | - | $362,580 | 281 | $4,832,138 | Jan 30 | Universal Pictures International (UPI) | false |
| 36 | Two Lovers | - | - | - | $355,899 | 108 | $1,339,026 | Mar 27 | BIM Distribuzione | false |
| 37 | Beverly Hills Chihuahua | - | - | - | $309,122 | 248 | $5,244,509 | Jan 16 | Walt Disney Pictures | false |
| 38 | Questo piccolo grande amore | - | - | - | $282,830 | 467 | $4,878,552 | Feb 11 | Medusa Distribuzione | false |
| 39 | Bride Wars | - | - | - | $230,900 | 285 | $1,742,791 | Feb 20 | 20th Century Fox International | false |
| 40 | The Visitor | - | - | - | $173,004 | 57 | $2,194,531 | Dec 5 | Bolero Film | false |
| 41 | Easy Virtue | - | - | - | $167,883 | 142 | $3,590,951 | Jan 9 | Eagle Pictures | false |
| 42 | The Boy in the Striped Pajamas | - | - | - | $164,263 | 103 | $3,802,419 | Dec 19 | Walt Disney Pictures | false |
| 43 | Frozen River | - | - | - | $150,065 | 20 | $267,882 | Mar 13 | Archibald | false |
| 44 | Lemon Tree | - | - | - | $124,818 | 47 | $1,471,720 | Dec 12 | Teodora Film | false |
| 45 | Impy's Wonderland | - | - | - | $123,774 | 143 | $273,774 | Feb 27 | Mediafilm | false |
| 46 | The Sicilian Girl | - | - | - | $103,425 | 53 | $199,438 | Feb 27 | Istituto Luce | false |
| 47 | L'ultimo Crodino | - | - | - | $100,711 | 101 | $106,456 | Mar 20 | Mikado Film | false |
| 48 | Márió, a varázsló | - | - | - | $96,805 | 12 | $238,776 | Nov 28 | L'Altrofilm | false |
| 49 | I've Loved You So Long | - | - | - | $89,820 | 54 | $554,704 | Feb 6 | Mikado Film | false |
| 50 | Doubt | - | - | - | $78,202 | 155 | $2,302,842 | Jan 30 | Walt Disney Pictures | false |
| 51 | Cenci in Cina | - | - | - | $70,077 | 7 | $129,951 | Mar 27 | - | false |
| 52 | Waltz with Bashir | - | - | - | $64,409 | 44 | $1,041,913 | Jan 9 | Lucky Red | false |
| 53 | Empties | - | - | - | $58,394 | 23 | $428,775 | Jan 16 | Fandango | false |
| 54 | Trappola d'autore | - | - | - | $56,556 | 9 | $118,875 | Mar 27 | - | false |
| 55 | Teza | - | - | - | $55,685 | 21 | $122,720 | Mar 27 | Ripley's Film | false |
| 56 | Friday the 13th | - | - | - | $53,824 | 198 | $1,613,528 | Feb 13 | Universal Pictures International (UPI) | false |
| 57 | L'ultimo Pulcinella | - | - | - | $52,440 | 21 | $56,978 | Mar 13 | Bolero Film | false |
| 58 | Katyn | - | - | - | $47,245 | 11 | $99,729 | Feb 13 | - | false |
| 59 | Mar nero | - | - | - | $31,950 | 10 | $128,060 | Jan 30 | - | false |
| 60 | In the Name of the King: A Dungeon Siege Tale | - | - | - | $29,555 | 13 | $34,923 | Feb 27 | One Movie | false |
| 61 | Il Sogno nel casello | - | - | - | $14,604 | 7 | $14,604 | Mar 13 | A.B. Film | false |
| 62 | Hotel for Dogs | - | - | - | $14,174 | 49 | $98,529 | Feb 20 | Universal Pictures International (UPI) | false |
| 63 | Space Chimps | - | - | - | $12,763 | 183 | $719,060 | Feb 6 | Medusa Distribuzione | false |
| 64 | Appaloosa | - | - | - | $12,470 | 37 | $387,450 | Jan 16 | 01 Distribution | false |
| 65 | Frost/Nixon | - | - | - | $11,956 | 151 | $879,567 | Feb 6 | Universal Pictures International (UPI) | false |
| 66 | American Virgin | - | - | - | $9,425 | 1 | $15,696 | Jun 7 | Eagle Pictures | false |
| 67 | Aria | - | - | - | $9,378 | 18 | $19,384 | Mar 20 | - | false |
| 68 | Waiting for the sun | - | - | - | $7,574 | 43 | $62,079 | Feb 20 | Mikado Film | false |
| 69 | Let the Right One In | - | - | - | $7,439 | 132 | $654,551 | Jan 9 | Bolero Film | false |
| 70 | Religulous | - | - | - | $6,682 | 22 | $102,320 | Feb 13 | Eagle Pictures | false |
| 71 | The Breath of the Soul | - | - | - | $5,676 | 4 | $5,676 | Mar 13 | - | false |
| 72 | Giovanna's Father | - | - | - | $4,960 | 357 | $4,846,636 | Sep 12 | Medusa Distribuzione | false |
| 73 | The First Day of Winter | - | - | - | $4,109 | 4 | $4,109 | Mar 27 | - | false |
| 74 | Impotenti esistenziali | - | - | - | $2,844 | 2 | $6,024 | Mar 20 | - | false |
| 75 | We Can Do That | - | - | - | $2,036 | 98 | $2,610,996 | Oct 31 | Warner Bros. | false |
| 76 | The Duchess | - | - | - | $1,772 | 202 | $2,901,441 | Dec 24 | BIM Distribuzione | false |
| 77 | My Enemy's Enemy | - | - | - | $1,335 | 1 | $3,141 | Jun 15 | Mikado Film | false |
| 78 | The Watcher | - | - | - | $1,214 | 1 | $3,037,400 | Sep 17 | Medusa Distribuzione | false |
