| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Slumdog Millionaire | - | - | - | $1,946,028 | 47 | $4,809,452 | Jan 9 | Pathé | false |
| 2 | Gran Torino | - | - | - | $1,737,763 | 53 | $2,296,282 | Feb 25 | Warner Bros. | false |
| 3 | Marley & Me | - | - | - | $1,321,232 | 88 | $1,378,244 | Mar 4 | 20th Century Fox International | false |
| 4 | The Reader | - | - | - | $1,154,587 | 47 | $1,495,763 | Feb 20 | Ascot Elite Entertainment Group | false |
| 5 | Watchmen | - | - | - | $596,018 | 53 | $605,706 | Mar 4 | - | false |
| 6 | Paul Blart: Mall Cop | - | - | - | $511,267 | 31 | $936,327 | Mar 26 | Walt Disney Pictures | false |
| 7 | Milk | - | - | - | $502,277 | 32 | $850,531 | Jan 23 | Ascot Elite Entertainment Group | false |
| 8 | Confessions of a Shopaholic | - | - | - | $445,332 | 44 | $534,974 | Feb 27 | Walt Disney Pictures | false |
| 9 | Yes Man | - | - | - | $395,958 | 52 | $1,342,175 | Jan 9 | Warner Bros. | false |
| 10 | Will You Marry Us? | - | - | - | $382,931 | 31 | $459,197 | Mar 19 | Walt Disney Pictures | false |
| 11 | Twilight | - | - | - | $357,316 | 82 | $2,986,625 | Nov 21 | Ascot Elite Entertainment Group | false |
| 12 | He's Just Not That Into You | - | - | - | $336,269 | 36 | $916,209 | Feb 12 | Warner Bros. | false |
| 13 | Coco | - | - | - | $335,322 | 14 | $425,773 | Mar 18 | JMH Distribution | false |
| 14 | Australia | - | - | - | $332,346 | 106 | $5,514,870 | Dec 24 | 20th Century Fox International | false |
| 15 | The Curious Case of Benjamin Button | - | - | - | $309,731 | 78 | $2,941,784 | Jan 29 | Warner Bros. | false |
| 16 | Home | - | - | - | $289,317 | 15 | $979,020 | Oct 15 | Filmcoopi Zürich | false |
| 17 | Lilly the Witch: The Dragon and the Magic Book | - | - | - | $275,156 | 45 | $508,100 | Feb 19 | Walt Disney Pictures | false |
| 18 | Hotel for Dogs | - | - | - | $259,745 | 49 | $937,916 | Feb 4 | Universal Pictures International (UPI) | false |
| 19 | The Pink Panther 2 | - | - | - | $258,831 | 38 | $241,728 | Feb 18 | Walt Disney Pictures | false |
| 20 | The International | - | - | - | $247,998 | 36 | $611,161 | Feb 12 | Walt Disney Pictures | false |
| 21 | The Unborn | - | - | - | $236,965 | 25 | $246,805 | Mar 11 | Universal Pictures International (UPI) | false |
| 22 | Mid-August Lunch | - | - | - | $232,181 | 13 | $312,912 | Dec 5 | Xenix Filmdistribution | false |
| 23 | Beverly Hills Chihuahua | - | - | - | $194,996 | 53 | $364,186 | Jan 16 | Walt Disney Pictures | false |
| 24 | Duplicity | - | - | - | $176,012 | 15 | $339,439 | Mar 25 | Universal Pictures International (UPI) | false |
| 25 | Revolutionary Road | - | - | - | $174,448 | 53 | $2,263,937 | Jan 15 | Universal Pictures International (UPI) | false |
| 26 | Bolt | - | - | - | $139,347 | 74 | $1,782,764 | Nov 28 | Walt Disney Pictures | false |
| 27 | The Wrestler | - | - | - | $127,029 | 20 | $262,176 | Feb 18 | Frenetic Films | false |
| 28 | The Tale of Despereaux | - | - | - | $117,390 | 38 | $191,882 | Feb 11 | Universal Pictures International (UPI) | false |
| 29 | Last Chance Harvey | - | - | - | $113,917 | 26 | $255,126 | Mar 18 | Ascot Elite Entertainment Group | false |
| 30 | Che: Part One | - | - | - | $95,927 | 12 | $324,440 | Jan 7 | Ascot Elite Entertainment Group | false |
| 31 | Red Cliff | - | - | - | $54,234 | 8 | $73,749 | Mar 25 | Ascot Elite Entertainment Group | false |
| 32 | Killing is My Business, Honey | - | - | - | $50,248 | 22 | $125,507 | Feb 26 | Warner Bros. | false |
| 33 | Role Models | - | - | - | $48,653 | 29 | $127,528 | Feb 25 | Universal Pictures International (UPI) | false |
| 34 | Marcello Marcello | - | - | - | $42,255 | 21 | $397,378 | Aug 22 | Filmcoopi Zürich | false |
| 35 | Frost/Nixon | - | - | - | $28,557 | 25 | $177,851 | Feb 12 | Universal Pictures International (UPI) | false |
| 36 | Changeling | - | - | - | $23,391 | 41 | $1,460,706 | Nov 12 | Universal Pictures International (UPI) | false |
| 37 | Fly Me to the Moon 3D | - | - | - | $22,061 | 2 | $130,523 | Oct 29 | - | false |
| 38 | Madagascar: Escape 2 Africa | - | - | - | $10,057 | 152 | $11,010,683 | Dec 3 | Universal Pictures International (UPI) | false |
| 39 | Friday the 13th | - | - | - | $7,170 | 27 | $314,414 | Feb 11 | Universal Pictures International (UPI) | false |
| 40 | Burn After Reading | - | - | - | $2,183 | 47 | $3,021,453 | Sep 19 | Ascot Elite Entertainment Group | false |
