| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Slumdog Millionaire | - | - | - | $82,632 | 5 | $111,240 | Mar 5 | Europa Filmes | false |
| 2 | Bedtime Stories | - | - | - | $61,416 | 5 | $83,516 | Mar 12 | Walt Disney Pictures | false |
| 3 | Twilight | - | - | - | $31,230 | 6 | $71,198 | Feb 19 | Manfer Films | false |
| 4 | Bride Wars | - | - | - | $30,011 | 4 | $60,262 | Feb 19 | 20th Century Fox International | false |
| 5 | Hotel for Dogs | - | - | - | $26,506 | 6 | $40,412 | Mar 19 | Paramount Pictures International | false |
| 6 | Journey to the Center of the Earth | - | - | - | $25,134 | 5 | $124,762 | Sep 18 | - | false |
| 7 | Valkyrie | - | - | - | $24,767 | 6 | $84,011 | Feb 12 | 20th Century Fox International | false |
| 8 | Inkheart | - | - | - | $23,816 | 6 | $23,816 | Mar 5 | - | false |
| 9 | Halloween | - | - | - | $21,044 | 3 | $21,044 | Mar 5 | - | false |
| 10 | Race to Witch Mountain | - | - | - | $16,581 | 5 | $111,046 | Mar 26 | Walt Disney Pictures | false |
| 11 | Fly Me to the Moon 3D | - | - | - | $14,836 | 2 | $33,209 | Feb 19 | - | false |
| 12 | Gran Torino | - | - | - | $14,827 | 3 | $23,679 | Mar 19 | Warner Bros. | false |
| 13 | Underworld: Rise of the Lycans | - | - | - | $10,349 | 4 | $40,237 | Mar 26 | Sony Pictures Releasing | false |
| 14 | The Tale of Despereaux | - | - | - | $10,024 | 6 | $19,664 | Feb 26 | - | false |
| 15 | Doubt | - | - | - | $8,671 | 3 | $8,671 | Mar 12 | Walt Disney Pictures | false |
| 16 | I Could Never Be Your Woman | - | - | - | $8,070 | 2 | $13,347 | Mar 19 | Trade International | false |
| 17 | The Curious Case of Benjamin Button | - | - | - | $5,837 | 6 | $113,052 | Jan 22 | Warner Bros. | false |
| 18 | The Flock | - | - | - | $5,686 | 2 | $5,686 | Mar 12 | - | false |
| 19 | Diary of the Dead | - | - | - | $4,381 | 2 | $31,910 | Feb 5 | - | false |
| 20 | Un Diá más | - | - | - | $4,080 | 1 | $4,080 | Mar 12 | - | false |
| 21 | 88 Minutes | - | - | - | $3,832 | 2 | $8,002 | Feb 26 | - | false |
| 22 | Seven Pounds | - | - | - | $3,804 | 6 | $44,437 | Jan 29 | Sony Pictures Releasing | false |
| 23 | Yes Man | - | - | - | $3,591 | 5 | $107,385 | Jan 8 | Warner Bros. | false |
| 24 | Lust, Caution | - | - | - | $1,750 | 2 | $3,717 | Mar 26 | Trade International | false |
| 25 | Shortbus | - | - | - | $1,230 | 1 | $1,230 | Mar 26 | - | false |
| 26 | U2 3D | - | - | - | $1,097 | 2 | $11,671 | Feb 4 | - | false |
