| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Watchmen | - | - | - | $496,468 | 40 | $506,821 | Mar 5 | United International Pictures | false |
| 2 | Race to Witch Mountain | - | - | - | $457,618 | 20 | $511,686 | Mar 12 | - | false |
| 3 | Marley & Me | - | - | - | $388,949 | 19 | $399,539 | Mar 5 | - | false |
| 4 | Friday the 13th | - | - | - | $349,896 | 20 | $392,837 | Mar 19 | United International Pictures | false |
| 5 | He's Just Not That Into You | - | - | - | $338,134 | 20 | $478,102 | Mar 19 | Italian International Film | false |
| 6 | Hotel for Dogs | - | - | - | $296,951 | 19 | $386,047 | Mar 12 | United International Pictures | false |
| 7 | Duplicity | - | - | - | $262,504 | 20 | $505,794 | Mar 26 | United International Pictures | false |
| 8 | Gran Torino | - | - | - | $257,382 | 19 | $263,940 | Mar 12 | - | false |
| 9 | Slumdog Millionaire | - | - | - | $232,877 | 23 | $1,319,117 | Jan 22 | Gulf Film | false |
| 10 | Nims Bond | - | - | - | $192,144 | 14 | $198,458 | Mar 12 | - | false |
| 11 | The International | - | - | - | $186,930 | 19 | $421,084 | Feb 26 | - | false |
| 12 | Mnahy | - | - | - | $180,124 | 20 | $199,368 | Mar 19 | - | false |
| 13 | The Pink Panther 2 | - | - | - | $142,764 | 19 | $846,694 | Feb 12 | - | false |
| 14 | What Just Happened | - | - | - | $136,833 | 14 | $141,111 | Mar 5 | Gulf Film | false |
| 15 | The Midnight Meat Train | - | - | - | $119,803 | 18 | $119,803 | Mar 12 | - | false |
| 16 | The Curious Case of Benjamin Button | - | - | - | $119,003 | 24 | $615,943 | Feb 19 | - | false |
| 17 | Day of the Dead | - | - | - | $90,871 | 20 | $223,460 | Feb 26 | - | false |
| 18 | Confessions of a Shopaholic | - | - | - | $82,249 | 16 | $361,219 | Feb 19 | - | false |
| 19 | Trade | - | - | - | $69,382 | 8 | $69,382 | Mar 19 | - | false |
| 20 | Crossing Over | - | - | - | $45,884 | 9 | $57,563 | Mar 5 | - | false |
| 21 | Garfield's Fun Fest | - | - | - | $36,678 | 17 | $124,361 | Feb 19 | - | false |
| 22 | Jonas Brothers: The 3D Concert Experience | - | - | - | $33,794 | 8 | $33,794 | Mar 19 | - | false |
| 23 | Penelope | - | - | - | $21,046 | 14 | $62,597 | Feb 26 | - | false |
| 24 | The Children of Huang Shi | - | - | - | $18,221 | 12 | $46,301 | Feb 26 | - | false |
| 25 | Yes Man | - | - | - | $16,544 | 20 | $738,370 | Jan 22 | - | false |
| 26 | Henry Poole Is Here | - | - | - | $16,323 | 7 | $16,323 | Mar 26 | - | false |
| 27 | Hasan Tayyarah | - | - | - | $12,891 | 10 | $33,551 | Feb 26 | - | false |
| 28 | Finding Amanda | - | - | - | $12,251 | 6 | $12,251 | Mar 12 | - | false |
| 29 | The Tale of Despereaux | - | - | - | $11,354 | 20 | $304,498 | Jan 29 | - | false |
| 30 | My Mom's New Boyfriend | - | - | - | $9,920 | 14 | $168,038 | Jan 29 | - | false |
| 31 | Madagascar: Escape 2 Africa | - | - | - | $9,600 | 27 | $1,908,261 | Nov 27 | - | false |
| 32 | Bella | - | - | - | $9,122 | 4 | $9,122 | Mar 12 | - | false |
| 33 | The Tattooist | - | - | - | $8,776 | 16 | $189,218 | Feb 19 | - | false |
| 34 | Twilight | - | - | - | $8,159 | 21 | $1,257,768 | Dec 4 | - | false |
| 35 | The Unborn | - | - | - | $6,871 | 20 | $512,033 | Feb 5 | - | false |
| 36 | Role Models | - | - | - | $5,459 | 11 | $135,192 | Feb 12 | - | false |
