| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Grande, grosso e... Verdone | - | - | - | $19,819,837 | 703 | $21,860,130 | Mar 7 | Filmauro | false |
| 2 | 10,000 BC | - | - | - | $7,656,384 | 454 | $8,188,578 | Mar 14 | Warner Bros. | false |
| 3 | No Country for Old Men | - | - | - | $6,088,603 | 308 | $8,979,650 | Feb 22 | Universal Pictures International (UPI) | false |
| 4 | Jumper | - | - | - | $4,435,948 | 317 | $4,435,948 | Feb 29 | 20th Century Fox International | false |
| 5 | Questa notte è ancora nostra | - | - | - | $4,348,210 | 399 | $5,201,233 | Mar 20 | Walt Disney Pictures | false |
| 6 | Before the Devil Knows You're Dead | - | - | - | $3,681,637 | 277 | $4,648,889 | Mar 14 | Medusa Distribuzione | false |
| 7 | Colpo d'occhio | - | - | - | $3,467,818 | 387 | $4,057,969 | Mar 20 | 01 Distribution | false |
| 8 | 27 Dresses | - | - | - | $3,089,826 | 263 | $3,860,905 | Mar 21 | 20th Century Fox International | false |
| 9 | The Kite Runner | - | - | - | $2,986,164 | 371 | $12,730,140 | Mar 28 | Filmauro | false |
| 10 | Sweeney Todd: The Demon Barber of Fleet Street | - | - | - | $2,921,710 | 325 | $6,176,046 | Feb 22 | Warner Bros. | false |
| 11 | The Spiderwick Chronicles | - | - | - | $2,787,333 | 262 | $3,505,964 | Mar 21 | Universal Pictures International (UPI) | false |
| 12 | Rambo | - | - | - | $2,326,967 | 409 | $5,859,791 | Feb 22 | Walt Disney Pictures | false |
| 13 | REC | - | - | - | $2,174,425 | 171 | $2,174,425 | Feb 29 | Mediafilm | false |
| 14 | Tell Me About Love | - | - | - | $1,870,632 | 595 | $11,537,025 | Feb 15 | 01 Distribution | false |
| 15 | Sorry, If I Love You | - | - | - | $1,789,596 | 508 | $20,913,254 | Jan 25 | Medusa Distribuzione | false |
| 16 | The Water Horse | - | - | - | $1,749,344 | 176 | $1,946,763 | Mar 14 | Sony Pictures Releasing | false |
| 17 | The Fox and the Child | - | - | - | $1,678,413 | 240 | $2,400,103 | Mar 21 | Lucky Red | false |
| 18 | Persepolis | - | - | - | $1,593,751 | 94 | $1,785,411 | Feb 22 | BIM Distribuzione | false |
| 19 | Tutta la vita davanti | - | - | - | $1,504,561 | 368 | $5,648,340 | Mar 28 | Medusa Distribuzione | false |
| 20 | Vantage Point | - | - | - | $1,476,040 | 274 | $1,476,040 | Feb 29 | Sony Pictures Releasing | false |
| 21 | The Early Bird Catches the Worm | - | - | - | $1,363,524 | 253 | $1,550,893 | Feb 29 | Medusa Distribuzione | false |
| 22 | Happily N'Ever After | - | - | - | $1,342,054 | 172 | $1,366,579 | Mar 7 | DNC Entertainment | false |
| 23 | Quiet Chaos | - | - | - | $1,331,804 | 384 | $9,204,569 | Feb 8 | 01 Distribution | false |
| 24 | Into the Wild | - | - | - | $1,289,442 | 191 | $8,058,998 | Jan 25 | BIM Distribuzione | false |
| 25 | There Will Be Blood | - | - | - | $1,184,299 | 111 | $2,566,966 | Feb 15 | Walt Disney Pictures | false |
| 26 | We Own the Night | - | - | - | $1,184,175 | 202 | $1,230,182 | Mar 14 | BIM Distribuzione | false |
| 27 | American Gangster | - | - | - | $593,523 | 457 | $15,520,131 | Jan 18 | Universal Pictures International (UPI) | false |
| 28 | Sex and Death 101 | - | - | - | $531,866 | 91 | $536,405 | Mar 14 | Moviemax | false |
| 29 | Asterix at the Olympic Games | - | - | - | $531,392 | 357 | $5,408,181 | Feb 8 | Warner Bros. | false |
| 30 | Rendition | - | - | - | $483,877 | 146 | $483,877 | Feb 29 | Eagle Pictures | false |
| 31 | The Band's Visit | - | - | - | $474,841 | 51 | $919,800 | Mar 21 | Mikado Film | false |
| 32 | Cassandra's Dream | - | - | - | $400,783 | 360 | $6,891,125 | Feb 1 | Filmauro | false |
| 33 | The Secret of the Grain | - | - | - | $366,668 | 79 | $2,875,013 | Jan 11 | Lucky Red | false |
| 34 | Odette Toulemonde | - | - | - | $361,318 | 26 | $415,310 | Mar 7 | Warner Bros. | false |
| 35 | Mr. Magorium's Wonder Emporium | - | - | - | $341,091 | 160 | $2,466,591 | Jan 25 | Moviemax | false |
| 36 | Alvin and the Chipmunks | - | - | - | $327,454 | 256 | $5,481,266 | Jan 18 | 20th Century Fox International | false |
| 37 | La rabbia | - | - | - | $284,542 | 15 | $383,975 | Feb 29 | L'Altrofilm | false |
| 38 | Sonetàula | - | - | - | $265,626 | 16 | $283,454 | Mar 7 | Lucky Red | false |
| 39 | My Blueberry Nights | - | - | - | $256,761 | 133 | $669,987 | Mar 28 | BIM Distribuzione | false |
| 40 | The Diving Bell and the Butterfly | - | - | - | $251,056 | 65 | $750,003 | Feb 15 | BIM Distribuzione | false |
| 41 | Charlie Wilson's War | - | - | - | $241,544 | 247 | $3,261,378 | Feb 8 | Universal Pictures International (UPI) | false |
| 42 | Irina Palm | - | - | - | $236,998 | 54 | $2,612,727 | Dec 7 | Teodora Film | false |
| 43 | Dan in Real Life | - | - | - | $203,817 | 125 | $311,839 | Mar 28 | Eagle Pictures | false |
| 44 | 30 Days of Night | - | - | - | $195,078 | 228 | $3,809,946 | Feb 8 | Medusa Distribuzione | false |
| 45 | Caramel | - | - | - | $188,755 | 50 | $2,301,033 | Dec 21 | Archibald | false |
| 46 | We Want Roses Too | - | - | - | $167,764 | 21 | $184,764 | Mar 7 | Mikado Film | false |
| 47 | Ci sta un francese, un inglese e un napoletano | - | - | - | $167,559 | 64 | $843,004 | Mar 28 | Medusa Distribuzione | false |
| 48 | Life Sentence | - | - | - | $164,157 | 34 | $166,726 | Feb 29 | Mikado Film | false |
| 49 | The Counterfeiters | - | - | - | $151,248 | 21 | $349,800 | Jan 25 | Lady Film | false |
| 50 | Black and White | - | - | - | $95,278 | 301 | $8,096,913 | Jan 11 | 01 Distribution | false |
| 51 | Joe Strummer: The Future Is Unwritten | - | - | - | $95,174 | 12 | $95,174 | Feb 29 | Ripley's Film | false |
| 52 | Biùtiful cauntri | - | - | - | $90,013 | 19 | $125,770 | Mar 7 | Lumière | false |
| 53 | Forse Dio è malato | - | - | - | $82,916 | 5 | $82,916 | Feb 29 | Istituto Luce | false |
| 54 | The Wind Blows Round | - | - | - | $80,328 | 15 | $659,151 | May 4 | Aranciafilm | false |
| 55 | The Savages | - | - | - | $61,785 | 27 | $498,767 | Jan 25 | 20th Century Fox International | false |
| 56 | Nelle tue mani | - | - | - | $58,920 | 18 | $111,266 | Mar 14 | Teodora Film | false |
| 57 | Cover Boy... Last Revolution | - | - | - | $58,115 | 8 | $147,184 | Mar 21 | Istituto Luce | false |
| 58 | Little Boy Red | - | - | - | $45,422 | 6 | $227,801 | Nov 16 | - | false |
| 59 | The Last Mimzy | - | - | - | $38,648 | 69 | $38,648 | Mar 14 | Eagle Pictures | false |
| 60 | Fallen Heroes | - | - | - | $37,433 | 22 | $81,917 | Mar 28 | BIM Distribuzione | false |
| 61 | Recto/Verso Undated Italy Release | - | - | - | $35,300 | 4 | $37,111 | - | - | false |
| 62 | Lust, Caution | - | - | - | $34,347 | 160 | $2,396,632 | Jan 4 | BIM Distribuzione | false |
| 63 | A Girl Cut in Two | - | - | - | $26,319 | 39 | $240,474 | Feb 8 | Mikado Film | false |
| 64 | P.S. I Love You | - | - | - | $26,032 | 250 | $1,870,319 | Feb 1 | 01 Distribution | false |
| 65 | Severance | - | - | - | $24,198 | 122 | $475,890 | Sep 21 | Medusa Distribuzione | false |
| 66 | Ratatouille | - | - | - | $7,590 | 658 | $25,880,003 | Oct 19 | Walt Disney Pictures | false |
| 67 | Mineurs | - | - | - | $6,185 | 1 | $29,916 | Nov 9 | - | false |
| 68 | Hui Buh: Das Schlossgespenst 2008 Re-release | - | - | - | $4,741 | 126 | $598,898 | Jan 4 | Moviemax | false |
| 69 | The Rest of the Night | - | - | - | $4,274 | 2 | $11,580 | Mar 13 | Independent Films | false |
| 70 | Cloverfield | - | - | - | $4,030 | 286 | $4,648,276 | Feb 1 | Universal Pictures International (UPI) | false |
| 71 | Bee Movie | - | - | - | $3,939 | 368 | $9,595,892 | Dec 21 | Universal Pictures International (UPI) | false |
| 72 | The Deer Hunter | - | - | - | $3,698 | 1 | $12,498 | - | Istituto Luce | false |
| 73 | Nazareno | - | - | - | $3,159 | 9 | $101,252 | Jun 29 | Mediaplex | false |
| 74 | Walk Hard: The Dewey Cox Story | - | - | - | $2,796 | 10 | $4,573 | Mar 28 | Sony Pictures Releasing | false |
| 75 | Il dolce e l'amaro | - | - | - | $2,756 | 243 | $1,445,130 | Sep 7 | Medusa Distribuzione | false |
| 76 | Signorina Effe | - | - | - | $2,554 | 71 | $524,476 | Jan 18 | 01 Distribution | false |
| 77 | The Nightmare Before Christmas 2008 3D Release | - | - | - | $2,530 | 9 | $144,321 | Nov 30 | Walt Disney Pictures | false |
| 78 | A Guide to Recognizing Your Saints | - | - | - | $2,481 | 3 | $288,539 | Mar 9 | Mikado Film | false |
| 79 | Love in the Time of Cholera | - | - | - | $2,424 | 203 | $5,462,115 | Dec 21 | 01 Distribution | false |
| 80 | Mars 2008 Re-release | - | - | - | $2,248 | 2 | $7,223 | Mar 28 | Officine UBU | false |
| 81 | I Am Legend | - | - | - | $2,191 | 506 | $21,020,300 | Jan 11 | Warner Bros. | false |
| 82 | Lezioni di cioccolato | - | - | - | $2,144 | 212 | $3,909,492 | Nov 23 | Universal Pictures International (UPI) | false |
| 83 | Across the Universe | - | - | - | $2,074 | 77 | $1,227,260 | Nov 23 | Sony Pictures Releasing | false |
| 84 | Elizabeth: The Golden Age | - | - | - | $2,049 | 333 | $6,808,077 | Oct 26 | Universal Pictures International (UPI) | false |
| 85 | Avenge But One of My Two Eyes | - | - | - | $1,899 | 3 | $1,899 | Mar 28 | Fandango | false |
| 86 | The Moustache | - | - | - | $1,883 | 22 | $210,359 | Jun 23 | Nexo | false |
| 87 | Come tu mi vuoi | - | - | - | $1,818 | 367 | $10,947,653 | Nov 9 | Medusa Distribuzione | false |
| 88 | The Jane Austen Book Club | - | - | - | $1,773 | 10 | $21,314 | Jan 18 | Sony Pictures Releasing | false |
| 89 | In Prison My Whole Life | - | - | - | $1,694 | 1 | $1,694 | Mar 28 | Fandango | false |
| 90 | The Bucket List | - | - | - | $1,672 | 243 | $2,820,300 | Jan 25 | Warner Bros. | false |
| 91 | Enchanted | - | - | - | $1,659 | 404 | $10,816,852 | Dec 7 | Walt Disney Pictures | false |
| 92 | La Vie En Rose | - | - | - | $1,545 | 162 | $1,458,533 | May 4 | Mikado Film | false |
| 93 | Le ferie di Licu | - | - | - | $1,320 | 6 | $142,015 | May 4 | Independent Films | false |
| 94 | The Golden Compass | - | - | - | $1,230 | 379 | $13,784,599 | Dec 14 | 01 Distribution | false |
