| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Silence of the Lambs | - | - | - | $50,068,960 | 1,642 | $130,742,922 | Feb 14 | Orion Pictures | false |
| 2 | Teenage Mutant Ninja Turtles II: The Secret of the Ooze | - | - | - | $35,095,839 | 2,868 | $78,656,813 | Mar 22 | New Line Cinema | false |
| 3 | Sleeping with the Enemy | - | - | - | $32,275,027 | 1,545 | $101,599,005 | Feb 8 | Twentieth Century Fox | false |
| 4 | The Doors | - | - | - | $28,882,588 | 1,236 | $34,416,893 | Mar 1 | TriStar Pictures | false |
| 5 | New Jack City | - | - | - | $26,487,936 | 905 | $47,624,353 | Mar 8 | Warner Bros. | false |
| 6 | Dances with Wolves | - | - | - | $23,809,901 | 1,636 | $184,208,848 | Nov 9 | Orion Pictures | false |
| 7 | The Hard Way | - | - | - | $18,779,589 | 1,629 | $25,895,485 | Mar 8 | Universal Pictures | false |
| 8 | Home Alone | - | - | - | $18,527,973 | 2,173 | $285,761,243 | Nov 16 | Twentieth Century Fox | false |
| 9 | King Ralph | - | - | - | $18,333,540 | 1,646 | $34,002,045 | Feb 15 | Universal Pictures | false |
| 10 | Shipwrecked | - | - | - | $15,104,156 | 1,393 | $15,104,156 | Mar 1 | Walt Disney Studios Motion Pictures | false |
| 11 | Class Action | - | - | - | $13,058,735 | 1,132 | $24,277,858 | Mar 15 | Twentieth Century Fox | false |
| 12 | L.A. Story | - | - | - | $10,564,904 | 1,122 | $28,862,081 | Feb 8 | TriStar Pictures | false |
| 13 | The Perfect Weapon | - | - | - | $9,165,455 | 1,229 | $14,061,361 | Mar 15 | Paramount Pictures | false |
| 14 | If Looks Could Kill | - | - | - | $7,788,597 | 838 | $7,788,597 | Mar 15 | Warner Bros. | false |
| 15 | White Fang | - | - | - | $7,205,340 | 1,259 | $34,793,160 | Jan 18 | Walt Disney Studios Motion Pictures | false |
| 16 | Guilty by Suspicion | - | - | - | $6,347,518 | 817 | $9,480,198 | Mar 15 | Warner Bros. | false |
| 17 | He Said, She Said | - | - | - | $6,159,360 | 908 | $9,804,775 | Feb 22 | Paramount Pictures | false |
| 18 | Green Card | - | - | - | $5,800,245 | 757 | $29,888,235 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 19 | Mr. & Mrs. Bridge | - | - | - | $5,419,967 | 240 | $7,698,010 | Nov 23 | Miramax | false |
| 20 | Kindergarten Cop | - | - | - | $5,235,248 | 1,937 | $91,457,688 | Dec 22 | Universal Pictures | false |
| 21 | La Femme Nikita | - | - | - | $5,017,971 | 118 | $5,017,971 | Mar 8 | The Samuel Goldwyn Company | false |
| 22 | Scenes from a Mall | - | - | - | $4,731,690 | 1,039 | $9,563,393 | Feb 22 | Walt Disney Studios Motion Pictures | false |
| 23 | Awakenings | - | - | - | $4,517,639 | 1,330 | $52,096,475 | Dec 22 | Columbia Pictures | false |
| 24 | The NeverEnding Story II: The Next Chapter | - | - | - | $4,449,908 | 1,208 | $17,373,527 | Feb 8 | Warner Bros. | false |
| 25 | Ghost | - | - | - | $3,927,096 | 1,766 | $217,631,306 | Jul 13 | Paramount Pictures | false |
| 26 | My Heroes Have Always Been Cowboys | - | - | - | $3,603,615 | 850 | $3,603,615 | Mar 1 | The Samuel Goldwyn Company | false |
| 27 | Career Opportunities | - | - | - | $2,381,430 | 1,440 | $11,336,986 | Mar 29 | Universal Pictures | false |
| 28 | The Long Walk Home | - | - | - | $1,988,272 | 272 | $4,873,620 | Dec 22 | Miramax | false |
| 29 | Nothing But Trouble | - | - | - | $1,586,713 | 1,671 | $8,479,793 | Feb 15 | Warner Bros. | false |
| 30 | The Field | - | - | - | $1,406,285 | 40 | $1,494,399 | Dec 22 | Avenue Pictures Productions | false |
| 31 | The Five Heartbeats | - | - | - | $1,026,588 | 862 | $8,750,400 | Mar 29 | Twentieth Century Fox | false |
| 32 | American Ninja 4: The Annihilation | - | - | - | $358,047 | 171 | $358,047 | Mar 8 | Cannon Film Distributors | false |
| 33 | Goodfellas | - | - | - | $352,093 | 1,328 | $46,836,214 | Sep 19 | Warner Bros. | false |
| 34 | Closet Land | - | - | - | $259,012 | 153 | $259,012 | Mar 6 | Universal Pictures | false |
| 35 | Defending Your Life | - | - | - | $201,786 | 715 | $16,371,128 | Mar 22 | Warner Bros. | false |
| 36 | The Godfather Part III | - | - | - | $157,713 | 1,922 | $66,666,062 | Dec 25 | Paramount Pictures | false |
| 37 | The Unborn | - | - | - | $96,402 | 67 | $1,159,578 | Mar 29 | Concorde Pictures | false |
| 38 | True Colors | - | - | - | $88,780 | 9 | $418,807 | Mar 15 | Paramount Pictures | false |
| 39 | Shadow of China | - | - | - | $55,166 | 4 | $55,166 | Mar 10 | New Line Cinema | false |
| 40 | The Comfort of Strangers | - | - | - | $21,723 | 17 | $1,244,381 | Mar 15 | Skouras Pictures | false |
| 41 | Open Doors | - | - | - | $21,292 | 6 | $123,470 | Mar 8 | Orion Classics | false |
| 42 | Ju Dou | - | - | - | $18,945 | 39 | $1,986,433 | Mar 6 | Miramax | false |
| 43 | Mister Johnson | - | - | - | $15,705 | 43 | $1,464,242 | Mar 22 | Avenue Pictures Productions | false |
| 44 | Robot Carnival | - | - | - | $10,642 | 2 | $10,642 | Mar 15 | - | false |
| 45 | Scissors | - | - | - | $2,368 | 1 | $2,368 | Mar 22 | - | false |
