| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | F9: The Fast Saga | - | - | - | $173,005,945 | 4,203 | $70,043,165 | 40.5% | 4,179 | Jun 25 | - | Universal Pictures | false |
| 2 | The Conjuring: The Devil Made Me Do It | - | - | - | $65,631,050 | 3,280 | $24,104,332 | 36.7% | 3,102 | Jun 4 | - | Warner Bros. | false |
| 3 | Peter Rabbit 2: The Runaway | - | - | - | $40,501,717 | 3,346 | $10,101,066 | 24.9% | 3,346 | Jun 11 | - | Sony Pictures Releasing | false |
| 4 | Hitman's Wife's Bodyguard | - | - | - | $38,014,727 | 3,361 | $11,397,820 | 30% | 3,331 | Jun 16 | - | Lionsgate | false |
| 5 | In the Heights | - | - | - | $29,975,167 | 3,509 | $11,504,710 | 38.4% | 3,456 | Jun 11 | - | Warner Bros. | false |
| 6 | Spirit Untamed | - | - | - | $17,716,215 | 3,394 | $6,101,050 | 34.4% | 3,211 | Jun 4 | - | Universal Pictures | false |
| 7 | Zola | - | - | - | $4,844,399 | 1,468 | $1,200,013 | 24.8% | 1,468 | Jun 30 | - | A24 | false |
| 8 | 12 Mighty Orphans | - | - | - | $3,689,637 | 1,047 | $251,569 | 6.8% | 132 | Jun 11 | - | Sony Pictures Releasing | false |
| 9 | The House Next Door: Meet the Blacks 2 | - | - | - | $2,893,660 | 539 | $1,011,756 | 35% | 420 | Jun 11 | - | Hidden Empire Film Group (HEFG) | false |
| 10 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | - | - | - | $2,320,649 | 752 | $802,054 | 34.6% | 752 | Jun 25 | - | Searchlight Pictures | false |
| 11 | Queen Bees | - | - | - | $1,926,706 | 600 | $375,232 | 19.5% | 500 | Jun 11 | - | Gravitas Ventures | false |
| 12 | Luca | - | - | - | $1,324,302 | 1,390 | - | - | - | Jun 18 | - | Walt Disney Studios Motion Pictures | false |
| 13 | Witnesses | - | - | - | $855,765 | 90 | $134,490 | 15.7% | 90 | Jun 4 | - | Purdie Distribution | false |
| 14 | The Sparks Brothers | - | - | - | $648,665 | 534 | $273,530 | 42.2% | 534 | Jun 18 | - | Focus Features | true |
| 15 | Werewolves Within | - | - | - | $575,783 | 270 | $250,811 | 43.6% | 270 | Jun 25 | - | IFC Films | false |
| 16 | Rita Moreno: Just a Girl Who Decided to Go for It | - | - | - | $264,626 | 227 | $84,366 | 31.9% | 227 | Jun 18 | - | Roadside Attractions | false |
| 17 | I Carry You with Me | - | - | - | $166,403 | 111 | $17,127 | 10.3% | 4 | Jun 25 | - | Sony Pictures Classics | false |
| 18 | Censor | - | - | - | $90,050 | 93 | $34,299 | 38.1% | 93 | Jun 11 | - | Magnolia Pictures | false |
| 19 | Undine | - | - | - | $78,689 | 56 | $27,065 | 34.4% | 56 | Jun 4 | - | IFC Films | false |
| 20 | Summer of 85 | - | - | - | $71,788 | 23 | $9,390 | 13.1% | 9 | Jun 18 | - | Music Box Films | false |
| 21 | The Red Circle 2021 Re-release | - | - | - | $62,850 | 5 | $9,033 | 14.4% | 1 | Jun 25 | - | Rialto Pictures | false |
| 22 | Lansky | - | - | - | $61,030 | 49 | $27,474 | 45% | 49 | Jun 25 | - | Vertical Entertainment | false |
| 23 | Truman & Tennessee: An Intimate Conversation | - | - | - | $54,817 | 22 | $9,050 | 16.5% | 16 | Jun 18 | - | Kino Lorber | false |
| 24 | DOMINO: Battle of the Bones | - | - | - | $50,124 | - | $50,124 | 100% | - | Jun 11 | - | TriCoast Worldwide | false |
| 25 | All Light, Everywhere | - | - | - | $37,266 | 19 | $5,376 | 14.4% | 2 | Jun 4 | - | Super LTD | false |
| 26 | Holler | - | - | - | $28,706 | 31 | $12,026 | 41.9% | 31 | Jun 11 | - | IFC Films | false |
| 27 | Our Ladies | - | - | - | $27,558 | 25 | $8,423 | 30.6% | 25 | Jun 18 | - | Sony Pictures Releasing | false |
| 28 | The Ladykillers 2021 Re-release | - | - | - | $23,213 | 3 | $5,038 | 21.7% | 1 | Jun 4 | - | Rialto Pictures | false |
| 29 | Gully | - | - | - | $22,517 | 100 | $14,425 | 64.1% | 100 | Jun 4 | - | Vertical Entertainment | false |
| 30 | A Soldier's Story 2: Return from the Dead | - | - | - | $21,543 | 5 | - | - | - | Jun 26 | - | Indican Pictures | false |
| 31 | Hero Mode | - | - | - | $21,178 | 46 | $11,843 | 55.9% | 46 | Jun 4 | - | Blue Fox Entertainment | false |
| 32 | Gaia | - | - | - | $17,530 | 75 | - | - | - | Jun 18 | - | Neon | false |
| 33 | Lydia Lunch: The War Is Never Over | - | - | - | $12,948 | 4 | $1,710 | 13.2% | 1 | Jun 30 | - | Kino Lorber | false |
| 34 | Sweat | - | - | - | $11,546 | 6 | $966 | 8.4% | 1 | Jun 18 | - | MUBI | false |
| 35 | Final Frequency | - | - | - | $7,098 | 9 | $4,735 | 66.7% | 9 | Jun 11 | - | Integrity Releasing | false |
| 36 | Crack House of the Dead | - | - | - | $1,616 | 5 | $1,287 | 79.6% | 5 | Jun 18 | - | Sunrayz International Films | false |
| 37 | The Evil Next Door | - | - | - | $1,010 | 3 | $303 | 30% | 3 | Jun 25 | - | Magnolia Pictures | false |
| 38 | Felix and the Hidden Treasure | - | - | - | $153 | 10 | - | - | - | Jun 25 | - | Viva Pictures | false |
