| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Conjuring: The Devil Made Me Do It | - | - | - | $2,052,276 | 397 | $2,480,536 | Jun 3 | Warner Bros. | false |
| 2 | Cruella | - | - | - | $1,863,066 | 569 | $2,878,387 | May 26 | Walt Disney Studios Motion Pictures | false |
| 3 | The Father | - | - | - | $773,463 | 338 | $1,447,821 | May 27 | BIM Distribuzione | false |
| 4 | Spirit Untamed | - | - | - | $398,277 | 316 | $489,639 | Jun 17 | Universal Pictures | false |
| 5 | A Quiet Place Part II | - | - | - | $392,634 | 392 | $1,083,221 | Jun 24 | Paramount Pictures | false |
| 6 | Spiral | - | - | - | $361,094 | 272 | $442,684 | Jun 16 | 01 Distribution | false |
| 7 | The Bad Poet | - | - | - | $296,047 | 322 | $890,592 | May 20 | 01 Distribution | false |
| 8 | Run | - | - | - | $283,616 | 240 | $300,603 | Jun 10 | STX International | false |
| 9 | Another Round | - | - | - | $256,598 | 242 | $815,062 | May 20 | Medusa Distribuzione | false |
| 10 | 100% Wolf | - | - | - | $218,541 | 193 | $443,476 | May 20 | BIM Distribuzione | false |
| 11 | Promising Young Woman | - | - | - | $173,683 | 275 | $496,677 | Jun 24 | Universal Pictures International (UPI) | false |
| 12 | Comedians | - | - | - | $171,399 | 321 | $180,721 | Jun 10 | 01 Distribution | false |
| 13 | Monster Hunter | - | - | - | $144,853 | 234 | $150,266 | Jun 17 | Warner Bros. | false |
| 14 | Nomadland | - | - | - | $106,647 | 195 | $2,356,666 | Apr 29 | Walt Disney Pictures | false |
| 15 | Perfumes | - | - | - | $69,779 | 52 | $130,344 | Jun 10 | Satine Film | false |
| 16 | Summer of 85 | - | - | - | $67,699 | 56 | $74,427 | Jun 3 | - | false |
| 17 | Freaky | - | - | - | $67,685 | 173 | $121,454 | May 27 | Universal Pictures International (UPI) | false |
| 18 | Sirley | - | - | - | $67,317 | 84 | $71,523 | Jun 3 | BIM Distribuzione | false |
| 19 | Rifkin's Festival | - | - | - | $66,315 | 205 | $740,455 | May 6 | - | false |
| 20 | Raya and the Last Dragon | - | - | - | $63,759 | 158 | $146,674 | Jun 24 | Walt Disney Studios Motion Pictures | false |
| 21 | The Unholy | - | - | - | $63,102 | 183 | $313,670 | May 20 | Sony Pictures Releasing | false |
| 22 | School of Mafia | - | - | - | $61,090 | 227 | $76,626 | Jun 24 | 01 Distribution | false |
| 23 | Lassie Come Home | - | - | - | $56,497 | 263 | $56,497 | Jun 10 | Lucky Red | false |
| 24 | Oldboy 2021 Re-release | - | - | - | $55,903 | 103 | $82,021 | Jun 9 | Lucky Red | false |
| 25 | The Shift 2021 Re-release | - | - | - | $48,072 | 144 | $48,072 | Jun 3 | BIM Distribuzione | false |
| 26 | Storm Boy 2021 Re-release | - | - | - | $37,536 | 219 | $49,076 | Jun 24 | Medusa Distribuzione | false |
| 27 | Herself | - | - | - | $27,966 | 73 | $28,353 | Jun 17 | BIM Distribuzione | false |
| 28 | Bon Jovi From Encore Nights | - | - | - | $27,172 | 158 | $27,172 | Jun 10 | Nexo Digital | false |
| 29 | Tutti per Uma | - | - | - | $26,507 | 202 | $39,424 | Jun 2 | - | false |
| 30 | The Eight Hundred | - | - | - | $26,403 | 101 | $29,931 | Jun 25 | BIM Distribuzione | false |
| 31 | Chungking Express 2021 Re-release | - | - | - | $26,055 | 15 | $47,219 | May 20 | Tucker Film | false |
| 32 | A Friendly Tale | - | - | - | $25,453 | 44 | $88,544 | Jun 24 | - | false |
| 33 | Lassie Come Home 2021 Re-release | - | - | - | $25,448 | 156 | $99,248 | Jun 10 | Lucky Red | false |
| 34 | Mandibles | - | - | - | $21,888 | 98 | $27,999 | Jun 17 | I Wonder Pictures | false |
| 35 | Happy Together | - | - | - | $19,148 | 6 | $22,005 | May 21 | Tucker Film | false |
| 36 | Voyagers | - | - | - | $19,062 | 60 | $20,869 | Jun 24 | Universal Pictures International (UPI) | false |
| 37 | The Cordillera of Dreams 2021 Re-release | - | - | - | $18,415 | 19 | $19,681 | Jun 10 | I Wonder Pictures | false |
| 38 | Memories of My Father | - | - | - | $17,463 | 56 | $17,722 | Jun 17 | Lucky Red | false |
| 39 | Minari | - | - | - | $16,552 | 74 | $308,013 | Apr 22 | - | false |
| 40 | In the Mood for Love 2021 Re-release | - | - | - | $16,528 | 29 | $188,856 | Apr 28 | Tucker Film | false |
| 41 | How to Be a Good Wife | - | - | - | $15,197 | 38 | $19,946 | Jun 24 | Movies Inspired | false |
| 42 | Adventures Italian Style | - | - | - | $11,990 | 99 | $78,410 | Apr 26 | Genoma Films | false |
| 43 | Diary of Love | - | - | - | $10,536 | 22 | $13,161 | May 27 | Europictures | false |
| 44 | Dear Diary | - | - | - | $9,012 | 21 | $104,450 | Oct 15 | Fondazione Cineteca di Bologna | false |
| 45 | The Human Voice | - | - | - | $7,415 | 83 | $49,913 | May 13 | Warner Bros. | false |
| 46 | About Endlessness | - | - | - | $6,021 | 15 | $9,743 | May 27 | Wanted | false |
| 47 | Fortuna | - | - | - | $5,963 | 32 | $14,950 | May 27 | I Wonder Pictures | false |
| 48 | The Personal History of David Copperfield | - | - | - | $5,465 | 369 | $437,065 | Oct 16 | Lucky Red | false |
| 49 | Misbehaviour | - | - | - | $5,336 | 67 | $42,836 | May 13 | BIM Distribuzione | false |
| 50 | Happy Together 2021 Re-release | - | - | - | $4,950 | 9 | $13,902 | May 20 | Tucker Film | false |
| 51 | Gloria Mundi | - | - | - | $3,940 | 21 | $34,296 | May 13 | Parthenos | false |
| 52 | Adam | - | - | - | $3,680 | 9 | $3,680 | Jun 3 | Movies Inspired | false |
| 53 | My Donkey, My Lover & I | - | - | - | $3,630 | 5 | $6,118 | Oct 6 | - | false |
| 54 | The Macaluso Sisters | - | - | - | $3,369 | 123 | $528,744 | Sep 10 | Teodora Film | false |
| 55 | The Conjuring 2 2021 Re-release | - | - | - | $3,297 | 4 | $166,657 | - | Warner Bros. | false |
| 56 | Come as You Are 2020 Re-release | - | - | - | $2,553 | 22 | $2,553 | Jun 24 | Wanted | false |
| 57 | Futura | - | - | - | $2,442 | 21 | $10,530 | Jun 17 | Adler Entertainment | false |
| 58 | Persian Lessons | - | - | - | $1,985 | 10 | $12,171 | Apr 26 | - | false |
| 59 | Valley of the Gods | - | - | - | $1,544 | 5 | $1,544 | Jun 3 | CG Entertainment | false |
| 60 | Miss Marx | - | - | - | $1,516 | 222 | $526,786 | Sep 17 | 01 Distribution | false |
| 61 | Kufid | - | - | - | $1,435 | 7 | $1,435 | Jun 17 | - | false |
| 62 | The Vegetarian | - | - | - | $1,407 | 1 | $24,089 | - | - | false |
| 63 | The Specials 2021 New-release | - | - | - | $1,395 | 2 | $7,355 | May 4 | Lucky Red | false |
| 64 | Ordinary Justice | - | - | - | $1,356 | 1 | $9,401 | Oct 22 | - | false |
| 65 | Pinocchio | - | - | - | $1,265 | 643 | $17,802,983 | Dec 19 | 01 Distribution | false |
| 66 | Guests in the Villa | - | - | - | $1,260 | 1 | $188,903 | - | - | false |
| 67 | Joker 2020 Re-release | - | - | - | $1,234 | 2 | $99,038 | - | Warner Bros. | false |
| 68 | Wonder Woman 1984 | - | - | - | $1,140 | 43 | $38,160 | May 13 | Warner Bros. | false |
| 69 | Nomad: In the Footsteps of Bruce Chatwin | - | - | - | $1,080 | 28 | $90,654 | Oct 19 | Wanted | false |
| 70 | Morrison | - | - | - | $1,054 | 142 | $29,519 | May 20 | Universal Pictures International (UPI) | false |
| 71 | Fallen Angels 2021 Re-release | - | - | - | $981 | 3 | $2,105 | May 22 | Tucker Film | false |
| 72 | Tom & Jerry | - | - | - | $905 | 55 | $41,235 | May 13 | Warner Bros. | false |
| 73 | Rassegna Cinematografica | - | - | - | $895 | 61 | $1,486,466 | Sep 8 | - | false |
| 74 | Forward | - | - | - | $813 | 10 | $2,637 | May 27 | Officine UBU | false |
| 75 | L'occhio di vetro | - | - | - | $813 | 1 | $813 | Jun 4 | - | false |
| 76 | Corpus Christi | - | - | - | $811 | 36 | $67,167 | May 6 | Wanted | false |
| 77 | Emma. | - | - | - | $737 | 10 | $37,602 | Jun 16 | Universal Pictures International (UPI) | false |
| 78 | Maledetto Modigliani | - | - | - | $733 | 1 | $200,359 | Oct 12 | Nexo Digital | false |
| 79 | La rivoluzione siamo noi (Arte in Italia 1967/1977) | - | - | - | $687 | 2 | $1,035 | Jun 16 | - | false |
| 80 | La belle époque | - | - | - | $660 | 177 | $1,939,692 | Nov 7 | I Wonder Pictures | false |
| 81 | Brooklyn 2021 Re-release | - | - | - | $645 | 1 | $326,014 | - | 20th Century Fox International | false |
| 82 | Stem Cell | - | - | - | $631 | 1 | $631 | Jun 18 | - | false |
| 83 | Gunda | - | - | - | $625 | 6 | $7,198 | May 13 | I Wonder Pictures | false |
| 84 | Days of Being Wild 2021 Re-release | - | - | - | $524 | 2 | $1,585 | May 23 | Tucker Film | false |
| 85 | Honeyland | - | - | - | $507 | 3 | $25,895 | Feb 12 | - | false |
| 86 | The Predators | - | - | - | $495 | 357 | $206,589 | Oct 22 | 01 Distribution | false |
| 87 | As Tears Go By 2021 Re-release | - | - | - | $483 | 1 | $1,730 | May 24 | Tucker Film | false |
| 88 | Two of Us | - | - | - | $460 | 22 | $62,797 | May 6 | Teodora Film | false |
| 89 | The Bears' Famous Invasion of Sicily | - | - | - | $457 | 184 | $511,923 | Nov 7 | BIM Distribuzione | false |
