| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Conjuring: The Devil Made Me Do It | - | - | - | $5,884,098 | 324 | $7,158,885 | Jun 4 | Warner Bros. | false |
| 2 | Cruella | - | - | - | $3,402,525 | 341 | $5,547,335 | May 28 | Walt Disney Studios Motion Pictures | false |
| 3 | A Quiet Place Part II | - | - | - | $1,479,085 | 332 | $1,968,789 | Jun 18 | Paramount Pictures International | false |
| 4 | Undercover Wedding Crashers | - | - | - | $1,037,746 | 353 | $3,871,185 | Jun 25 | Walt Disney Pictures | false |
| 5 | Spirit Untamed | - | - | - | $692,777 | 325 | $2,021,568 | Jun 25 | Universal Pictures | false |
| 6 | Wrath of Man | - | - | - | $561,511 | 240 | $905,292 | May 28 | Miramax | false |
| 7 | Spiral | - | - | - | $411,545 | 280 | $1,160,969 | May 21 | DeAPlaneta | false |
| 8 | Raya and the Last Dragon | - | - | - | $342,061 | 149 | $2,944,461 | Mar 5 | Walt Disney Pictures | false |
| 9 | Hitman's Wife's Bodyguard | - | - | - | $339,739 | 297 | $705,144 | Jun 18 | Vértice 360 | false |
| 10 | In the Heights | - | - | - | $308,509 | 308 | $391,508 | Jun 18 | Warner Bros. | false |
| 11 | Let Him Go | - | - | - | $197,355 | 205 | $299,244 | May 28 | United International Pictures | false |
| 12 | The House of Snails | - | - | - | $148,668 | 178 | $149,607 | Jun 11 | Filmax | false |
| 13 | Memories of My Father | - | - | - | $146,656 | 163 | $911,827 | May 7 | BTeam Pictures | false |
| 14 | Tom & Jerry | - | - | - | $146,136 | 160 | $3,206,678 | Mar 26 | Warner Bros. | false |
| 15 | Maya the Bee 3: The Golden Orb | - | - | - | $104,070 | 190 | $142,750 | May 28 | Media Solutions Partners (MSP) | false |
| 16 | My Salinger Year | - | - | - | $91,083 | 80 | $91,369 | Jun 4 | A Contracorriente Films | false |
| 17 | Land | - | - | - | $90,801 | 46 | $90,801 | Jun 11 | United International Pictures | false |
| 18 | Polyamory for Dummies | - | - | - | $76,768 | 293 | $320,797 | May 21 | Vértice 360 | false |
| 19 | Two by Two: Overboard! | - | - | - | $69,033 | 135 | $727,976 | Apr 16 | Flins & Piniculas | false |
| 20 | The Last Bus | - | - | - | $66,932 | 47 | $79,080 | Jun 18 | DeAPlaneta | false |
| 21 | A Friendly Tale | - | - | - | $56,367 | 69 | $98,167 | Jun 25 | A Contracorriente Films | false |
| 22 | There Is No Evil | - | - | - | $31,398 | 36 | $41,636 | Jun 25 | BTeam Pictures | false |
| 23 | First Cow | - | - | - | $27,908 | 76 | $121,809 | May 21 | Avalon | false |
| 24 | Just One Time | - | - | - | $27,162 | 63 | $28,263 | Jun 11 | A Contracorriente Films | false |
| 25 | Another Round | - | - | - | $27,063 | 29 | $1,168,039 | Apr 9 | BTeam Pictures | false |
| 26 | The Year of Fury | - | - | - | $18,759 | 57 | $35,910 | May 28 | Filmax | false |
| 27 | Nación | - | - | - | $18,429 | 14 | $20,541 | Mar 26 | - | false |
| 28 | Mighty Flash | - | - | - | $18,369 | 20 | $19,445 | Jun 18 | - | false |
| 29 | Reservoir Dogs 2021 Re-release | - | - | - | $16,566 | 134 | $21,214 | Jun 4 | - | false |
| 30 | La Piel del Volcan | - | - | - | $16,332 | 8 | $37,836 | May 21 | Independent Films | false |
| 31 | Long Story Short | - | - | - | $14,696 | 89 | $27,734 | Jun 4 | Vértigo Films | false |
| 32 | Karen | - | - | - | $12,141 | 23 | $12,141 | Jun 4 | Begin Again Films | false |
| 33 | The Hobbit: The Battle of the Five Armies 2020 Re-release | - | - | - | $11,794 | 93 | $5,710,065 | - | Warner Bros. | false |
| 34 | The Good Traitor | - | - | - | $11,274 | 56 | $11,274 | Jun 4 | VerCine | false |
| 35 | The Bad Poet | - | - | - | $10,508 | 36 | $12,529 | Jun 18 | Alfa Films | false |
| 36 | Historias lamentables | - | - | - | $10,160 | 17 | $12,020 | Jun 11 | - | false |
| 37 | Welcome to Spain | - | - | - | $9,568 | 23 | $6,662 | Jun 18 | Independent Films | false |
| 38 | La escopeta nacional 2021 Re-release | - | - | - | $8,078 | 10 | $6,820 | Jun 18 | A Contracorriente Films | false |
| 39 | Nomadland | - | - | - | $7,585 | 91 | $2,753,594 | Mar 26 | Walt Disney Pictures | false |
| 40 | Lucas | - | - | - | $4,617 | 6 | $7,153 | Jun 25 | Begin Again Films | false |
| 41 | Cuñados | - | - | - | $3,882 | 15 | $314,944 | Apr 9 | Filmax | false |
| 42 | Surcos | - | - | - | $3,871 | 7 | $8,932 | May 28 | Phoenix Productions (II) | false |
| 43 | Vivo | - | - | - | $3,774 | 21 | $276,764 | Apr 9 | Bosco Films | false |
| 44 | The Most Beautiful Day in the World | - | - | - | $3,286 | 1 | $3,497 | Jun 25 | Bosco Films | false |
| 45 | Bon Jovi From Encore Nights | - | - | - | $2,480 | 130 | $4,442 | Jun 11 | - | false |
| 46 | The Great Way | - | - | - | $2,445 | 9 | $5,672 | Jun 25 | Super 8 | false |
| 47 | Armugan | - | - | - | $1,929 | 8 | $3,344 | May 7 | - | false |
| 48 | Chacun chez soi | - | - | - | $1,799 | 51 | $1,799 | Jun 4 | DeAPlaneta | false |
| 49 | The Violin Player | - | - | - | $1,509 | 70 | $1,509 | Jun 11 | Adso Films | false |
| 50 | Mía & Moi | - | - | - | $1,374 | 9 | $11,841 | May 21 | Yedra Films | false |
| 51 | Perifèria | - | - | - | $1,350 | 3 | $2,429 | Jun 11 | - | false |
| 52 | La Sombra | - | - | - | $1,102 | 3 | $2,187 | Jun 25 | Phoenix Productions (II) | false |
| 53 | Islandia: El Refugio Perfecto | - | - | - | $954 | 1 | $2,146 | Apr 30 | - | false |
| 54 | Chaos Walking | - | - | - | $810 | 94 | $612,765 | Apr 30 | Entertainment One | false |
| 55 | Gaza mon amour | - | - | - | $488 | 55 | $488 | Jun 4 | Karma Films | false |
| 56 | Crónica de una tormenta | - | - | - | $443 | 1 | $18,098 | Apr 30 | Syldavia Cinema | false |
| 57 | La Cumbre es el Camino | - | - | - | $349 | 1 | $1,132 | Mar 26 | Independent Films | false |
| 58 | One for All | - | - | - | $243 | 1 | $231,138 | Sep 18 | A Contracorriente Films | false |
| 59 | Between Dog and Wolf | - | - | - | $129 | 5 | $193 | Jun 18 | Begin Again Films | false |
| 60 | Antonio Machado. Los días azules | - | - | - | $106 | 1 | $6,993 | Dec 4 | - | false |
| 61 | Eroski Paraíso | - | - | - | $95 | 1 | $11,512 | - | - | false |
| 62 | El Drogas | - | - | - | $88 | 1 | $71,849 | Sep 25 | Golem Distribución | false |
| 63 | Death Knell | - | - | - | $86 | 136 | $45,982 | Nov 20 | Barton Films | false |
| 64 | Yesterday's Two Nights | - | - | - | $51 | 1 | $12,889 | Mar 12 | Splendor Films | false |
| 65 | Jaulas | - | - | - | $46 | 1 | $13,577 | - | A Contracorriente Films | false |
| 66 | My Mexican Bretzel | - | - | - | $32 | 29 | $50,887 | Dec 11 | Avalon | false |
| 67 | A Fantastic Woman 2021 Re-release | - | - | - | $32 | 1 | $137,011 | - | BTeam Pictures | false |
| 68 | Almost 40 | - | - | - | $29 | 49 | $159,625 | Jun 29 | Avalon | false |
| 69 | Trolls World Tour | - | - | - | $26 | 223 | $3,357,870 | Oct 23 | Universal Pictures International (UPI) | false |
