| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $258,377 | 9 | $768,158 | May 18 | Walt Disney Pictures | false |
| 2 | The Hangover Part II | - | - | - | $197,114 | 8 | $345,540 | May 25 | Warner Bros. | false |
| 3 | Kung Fu Panda 2 | - | - | - | $177,253 | 10 | $268,439 | Jun 1 | United International Pictures | false |
| 4 | X-Men: First Class | - | - | - | $135,800 | 9 | $175,533 | Jun 1 | 20th Century Fox International | false |
| 5 | Green Lantern | - | - | - | $100,325 | 10 | $166,999 | Jun 15 | Warner Bros. | false |
| 6 | Fast Five | - | - | - | $89,193 | 10 | $447,618 | May 4 | United International Pictures | false |
| 7 | Something Borrowed | - | - | - | $62,601 | 5 | $87,322 | Jun 8 | - | false |
| 8 | Cars 2 | - | - | - | $49,538 | 7 | $194,897 | Jun 22 | Walt Disney Pictures | false |
| 9 | Super 8 | - | - | - | $48,836 | 9 | $75,128 | Jun 15 | United International Pictures | false |
| 10 | Rio | - | - | - | $39,427 | 8 | $222,373 | Apr 27 | 20th Century Fox International | false |
| 11 | Priest | - | - | - | $28,604 | 8 | $47,672 | May 25 | Sony Pictures Releasing | false |
| 12 | Bad Teacher | - | - | - | $28,259 | 5 | $135,847 | Jun 22 | Sony Pictures Releasing | false |
| 13 | The Hole | - | - | - | $25,972 | 3 | $30,657 | Jun 8 | - | false |
| 14 | Water for Elephants | - | - | - | $19,913 | 5 | $33,936 | May 25 | 20th Century Fox International | false |
| 15 | Scream 4 | - | - | - | $19,100 | 7 | $118,717 | Apr 27 | - | false |
| 16 | Last Night | - | - | - | $6,590 | 3 | $11,642 | Jun 22 | - | false |
| 17 | The Rite | - | - | - | $6,572 | 8 | $164,664 | Mar 9 | Warner Bros. | false |
| 18 | Just Go with It | - | - | - | $6,040 | 6 | $123,147 | Feb 23 | Sony Pictures Releasing | false |
| 19 | Thor | - | - | - | $2,922 | 10 | $156,908 | Apr 27 | United International Pictures | false |
| 20 | Unknown | - | - | - | $1,745 | 8 | $132,107 | Mar 23 | Warner Bros. | false |
| 21 | Hall Pass | - | - | - | $1,582 | 5 | $58,010 | Apr 13 | Warner Bros. | false |
| 22 | The Adjustment Bureau | - | - | - | $1,564 | 9 | $67,013 | Apr 13 | United International Pictures | false |
| 23 | Paul | - | - | - | $1,273 | 4 | $19,858 | May 11 | United International Pictures | false |
| 24 | No Strings Attached | - | - | - | $1,024 | 8 | $88,829 | Mar 30 | United International Pictures | false |
| 25 | Tomorrow, When the War Began | - | - | - | $816 | 5 | $6,598 | May 25 | - | false |
| 26 | Rango | - | - | - | $775 | 7 | $39,385 | Apr 13 | United International Pictures | false |
| 27 | Ironclad | - | - | - | $186 | 6 | $26,406 | May 11 | - | false |
| 28 | Red Riding Hood | - | - | - | $119 | 3 | $32,990 | Apr 20 | Warner Bros. | false |
