| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Schuks Tshabalala's Survival Guide to South Africa | - | - | - | $3,070,414 | 110 | $5,148,841 | May 28 | - | false |
| 2 | Toy Story 3 | - | - | - | $1,481,276 | 107 | $3,344,199 | Jun 25 | Walt Disney Pictures | false |
| 3 | Prince of Persia: The Sands of Time | - | - | - | $873,436 | 93 | $1,803,854 | May 21 | Walt Disney Pictures | false |
| 4 | Marmaduke | - | - | - | $764,282 | 56 | $1,101,621 | Jun 11 | 20th Century Fox International | false |
| 5 | Killers | - | - | - | $735,230 | 50 | $1,085,954 | Jun 4 | NuMetro Distribution | false |
| 6 | Sex and the City 2 | - | - | - | $653,433 | 72 | $981,707 | May 28 | 20th Century Fox International | false |
| 7 | Death at a Funeral | - | - | - | $419,665 | 45 | $1,098,918 | Jun 18 | Sony Pictures Releasing | false |
| 8 | Letters to Juliet | - | - | - | $333,017 | 42 | $477,259 | Jun 11 | NuMetro Distribution | false |
| 9 | Robin Hood | - | - | - | $298,543 | 80 | $1,140,199 | May 14 | United International Pictures | false |
| 10 | Iron Man 2 | - | - | - | $265,812 | 79 | $2,589,816 | Apr 30 | Paramount Pictures International | false |
| 11 | Green Zone 2010 Re-release | - | - | - | $182,419 | 45 | $289,702 | May 28 | United International Pictures | false |
| 12 | She's Out of My League | - | - | - | $181,109 | 42 | $668,820 | Jun 25 | United International Pictures | false |
| 13 | The Back-up Plan | - | - | - | $160,552 | 50 | $770,599 | May 7 | Sony Pictures Releasing | false |
| 14 | The Last Song | - | - | - | $152,413 | 35 | $385,001 | May 14 | Walt Disney Pictures | false |
| 15 | Space Chimps 2: Zartog Strikes Back | - | - | - | $124,475 | 27 | $180,842 | May 28 | United International Pictures | false |
| 16 | Legion | - | - | - | $90,428 | 25 | $90,428 | Jun 4 | Sony Pictures Releasing | false |
| 17 | Egoli: Afrikaners is Plesierig | - | - | - | $53,736 | 46 | $53,736 | Jun 18 | - | false |
| 18 | The Imaginarium of Doctor Parnassus | - | - | - | $45,885 | 10 | $68,911 | Jun 11 | NuMetro Distribution | false |
| 19 | The Fourth Kind | - | - | - | $45,763 | 20 | $60,775 | Jun 25 | NuMetro Distribution | false |
| 20 | Raavan | - | - | - | $38,851 | 13 | $38,851 | Jun 18 | - | false |
| 21 | Broken Embraces | - | - | - | $31,559 | 5 | $83,834 | Jun 18 | Ster-Kinekor Pictures | false |
| 22 | A Serious Man | - | - | - | $28,088 | 10 | $105,268 | May 14 | Ster-Kinekor Pictures | false |
| 23 | Youth in Revolt | - | - | - | $25,872 | 16 | $25,872 | Jun 18 | Ster-Kinekor Pictures | false |
| 24 | The Ghost Writer | - | - | - | $18,342 | 20 | $65,716 | May 21 | NuMetro Distribution | false |
| 25 | Kites | - | - | - | $17,836 | 12 | $81,429 | May 21 | - | false |
| 26 | Creation | - | - | - | $16,263 | 7 | $72,239 | Jun 25 | Ster-Kinekor Pictures | false |
| 27 | Endgame | - | - | - | $13,789 | 5 | $16,615 | Jun 11 | United International Pictures | false |
| 28 | District 13: Ultimatum | - | - | - | $10,286 | 10 | $10,286 | Jun 11 | - | false |
| 29 | I Now Pronounce You Black and White | - | - | - | $9,030 | 38 | $126,218 | May 14 | - | false |
| 30 | The Last Station 2010 Re-release | - | - | - | $9,003 | 12 | $151,078 | Mar 26 | Ster-Kinekor Pictures | false |
| 31 | Nanny McPhee Returns | - | - | - | $7,411 | 42 | $561,898 | Apr 1 | United International Pictures | false |
| 32 | Seraphine | - | - | - | $7,189 | 3 | $27,256 | May 7 | Ster-Kinekor Pictures | false |
| 33 | Edge of Darkness | - | - | - | $5,425 | 45 | $244,920 | May 7 | NuMetro Distribution | false |
| 34 | Paris 36 | - | - | - | $4,353 | 3 | $6,858 | May 28 | Ster-Kinekor Pictures | false |
| 35 | To Save a Life | - | - | - | $3,765 | 20 | $3,765 | Jun 4 | NuMetro Distribution | false |
| 36 | The Men Who Stare at Goats | - | - | - | $3,185 | 15 | $71,929 | Apr 30 | NuMetro Distribution | false |
| 37 | Date Night | - | - | - | $2,113 | 60 | $807,654 | Apr 9 | 20th Century Fox International | false |
