| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Sex and the City 2 | - | - | - | $5,654,719 | 476 | $7,802,889 | May 28 | Warner Bros. | false |
| 2 | Prince of Persia: The Sands of Time | - | - | - | $3,577,163 | 548 | $8,912,558 | May 19 | Walt Disney Pictures | false |
| 3 | Robin Hood | - | - | - | $2,713,434 | 667 | $14,676,791 | May 12 | United International Pictures | false |
| 4 | The A-Team | - | - | - | $2,274,492 | 354 | $3,143,928 | Jun 18 | 20th Century Fox International | false |
| 5 | The Hole | - | - | - | $1,995,721 | 310 | $2,094,728 | Jun 11 | Medusa Distribuzione | false |
| 6 | Avatar | - | - | - | $1,971,992 | 856 | $93,746,295 | Jan 15 | 20th Century Fox International | false |
| 7 | La nostra vita | - | - | - | $1,948,428 | 269 | $4,400,186 | May 21 | 01 Distribution | false |
| 8 | The Final Destination | - | - | - | $1,873,964 | 338 | $4,590,236 | May 21 | Warner Bros. | false |
| 9 | Saw VI | - | - | - | $1,752,958 | 300 | $2,520,502 | Jun 1 | 01 Distribution | false |
| 10 | Nanny McPhee Returns | - | - | - | $1,635,851 | 198 | $1,774,751 | Jun 4 | United International Pictures | false |
| 11 | The Road | - | - | - | $1,152,938 | 151 | $1,630,241 | May 28 | - | false |
| 12 | Pope Joan | - | - | - | $868,014 | 148 | $925,787 | Jun 4 | Medusa Distribuzione | false |
| 13 | The Secret in Their Eyes | - | - | - | $830,359 | 73 | $1,566,701 | Jun 4 | Lucky Red | false |
| 14 | I Hate Valentine's Day | - | - | - | $778,035 | 161 | $982,592 | Jun 18 | Eagle Pictures | false |
| 15 | Bright Star | - | - | - | $647,436 | 97 | $912,003 | Jun 11 | 01 Distribution | false |
| 16 | The Girl Who Kicked the Hornet's Nest | - | - | - | $551,951 | 186 | $818,396 | May 28 | BIM Distribuzione | false |
| 17 | Draquila - L'Italia che trema | - | - | - | $403,138 | 28 | $2,124,529 | May 7 | BIM Distribuzione | false |
| 18 | Tooth Fairy | - | - | - | $400,047 | 91 | $458,881 | Jun 11 | 20th Century Fox International | false |
| 19 | Cop Out | - | - | - | $299,045 | 180 | $612,421 | Jun 25 | Warner Bros. | false |
| 20 | The Back-up Plan | - | - | - | $291,576 | 233 | $1,926,942 | May 14 | Sony Pictures Releasing | false |
| 21 | L'imbroglio nel lenzuolo | - | - | - | $290,407 | 51 | $492,068 | Jun 18 | 01 Distribution | false |
| 22 | She's Out of My League | - | - | - | $258,695 | 60 | $308,584 | Jun 18 | United International Pictures | false |
| 23 | Una canzone per te | - | - | - | $204,497 | 205 | $413,920 | May 28 | United International Pictures | false |
| 24 | The Time That Remains | - | - | - | $176,382 | 29 | $195,172 | Jun 4 | BIM Distribuzione | false |
| 25 | Remembering the Children | - | - | - | $148,987 | 22 | $263,808 | Jun 11 | Teodora Film | false |
| 26 | The Ghost Writer | - | - | - | $134,748 | 352 | $4,811,454 | Apr 9 | 01 Distribution | false |
| 27 | Certified Copy | - | - | - | $133,483 | 55 | $338,271 | May 21 | BIM Distribuzione | false |
| 28 | Furry Vengeance | - | - | - | $108,245 | 226 | $1,556,613 | May 7 | Eagle Pictures | false |
| 29 | The Last Station 2010 Re-release | - | - | - | $86,816 | 30 | $124,692 | May 28 | Sony Pictures Releasing | false |
| 30 | City Island | - | - | - | $84,375 | 51 | $234,113 | Jun 25 | Mikado Film | false |
| 31 | About Elly | - | - | - | $78,561 | 23 | $161,220 | Jun 18 | - | false |
| 32 | Departures | - | - | - | $44,984 | 42 | $868,327 | Apr 9 | - | false |
| 33 | The Maid | - | - | - | $37,966 | 14 | $176,605 | Jun 25 | - | false |
| 34 | Universal Soldier: Regeneration | - | - | - | $17,061 | - | $17,061 | Jun 4 | - | false |
| 35 | 18 Years Later | - | - | - | $15,365 | - | $15,365 | Jun 4 | - | false |
| 36 | All About Steve | - | - | - | $7,783 | 10 | $7,783 | Jun 25 | 20th Century Fox International | false |
| 37 | Come Undone | - | - | - | $7,434 | 284 | $2,548,548 | Apr 30 | Warner Bros. | false |
| 38 | OceanWorld | - | - | - | $7,379 | 266 | $3,297,162 | Apr 30 | Eagle Pictures | false |
| 39 | Le Quattro Volte | - | - | - | $5,810 | 7 | $79,355 | May 28 | - | false |
| 40 | The Man Who Will Come | - | - | - | $5,463 | 69 | $1,877,452 | Jan 22 | Mikado Film | false |
