| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Prince of Persia: The Sands of Time | - | - | - | $5,537,782 | 603 | $13,327,923 | May 21 | Walt Disney Pictures | false |
| 2 | Sex and the City 2 | - | - | - | $4,893,241 | 347 | $5,814,149 | Jun 4 | Warner Bros. | false |
| 3 | Robin Hood | - | - | - | $2,546,692 | 540 | $13,683,489 | May 13 | United International Pictures | false |
| 4 | Dorian Gray | - | - | - | $2,544,398 | 239 | $3,560,230 | Jun 11 | Aurum Films | false |
| 5 | Marmaduke | - | - | - | $2,360,097 | 325 | $3,898,249 | Jun 18 | 20th Century Fox International | false |
| 6 | The Last Song | - | - | - | $1,851,407 | 317 | $1,997,548 | Jun 4 | Walt Disney Pictures | false |
| 7 | Legion | - | - | - | $1,824,892 | 297 | $3,213,507 | May 28 | Sony Pictures Releasing | false |
| 8 | The Blind Side | - | - | - | $1,441,567 | 223 | $2,529,601 | Jun 18 | Warner Bros. | false |
| 9 | Garfield's Pet Force | - | - | - | $1,119,067 | 213 | $1,232,775 | Jun 11 | - | false |
| 10 | Kick-Ass | - | - | - | $1,107,121 | 271 | $1,257,505 | Jun 4 | United International Pictures | false |
| 11 | StreetDance 2 | - | - | - | $1,031,650 | 210 | $1,607,853 | May 28 | Aurum Films | false |
| 12 | To Hell with the Ugly | - | - | - | $696,959 | 296 | $9,246,548 | Apr 23 | Warner Bros. | false |
| 13 | The Other Man | - | - | - | $679,425 | 112 | $843,394 | Jun 11 | DeAPlaneta | false |
| 14 | La última cima | - | - | - | $645,319 | 72 | $968,401 | Jun 4 | - | false |
| 15 | Law Abiding Citizen | - | - | - | $636,410 | 301 | $4,678,297 | May 7 | Warner Bros. | false |
| 16 | Two Lovers | - | - | - | $532,211 | 125 | $1,768,721 | May 14 | DeAPlaneta | false |
| 17 | The Crazies | - | - | - | $520,393 | 203 | $827,739 | May 28 | - | false |
| 18 | Campamento Flipy | - | - | - | $505,169 | 180 | $531,355 | Jun 11 | Walt Disney Pictures | false |
| 19 | Hot Tub Time Machine | - | - | - | $433,098 | 240 | $744,973 | May 28 | DeAPlaneta | false |
| 20 | Scar | - | - | - | $407,351 | 224 | $648,382 | Jun 25 | DeAPlaneta | false |
| 21 | Furry Vengeance | - | - | - | $377,453 | 238 | $886,748 | Jun 25 | Aurum Films | false |
| 22 | La venganza de Ira Vamp | - | - | - | $366,763 | 255 | $418,467 | Jun 18 | Sony Pictures Releasing | false |
| 23 | The Last Station 2010 Re-release | - | - | - | $305,329 | 31 | $450,391 | Jun 11 | Sony Pictures Releasing | false |
| 24 | I Am Love | - | - | - | $236,749 | 28 | $586,094 | May 21 | Alta Films | false |
| 25 | The Private Lives of Pippa Lee | - | - | - | $223,038 | 103 | $556,691 | Jun 25 | TriPictures | false |
| 26 | Villa Amalia 2009 Re-release | - | - | - | $219,286 | 30 | $402,622 | Jun 18 | Karma Films | false |
| 27 | Vincere | - | - | - | $182,775 | 26 | $239,002 | Jun 11 | - | false |
| 28 | Pièce montée | - | - | - | $170,843 | 82 | $482,037 | May 21 | - | false |
| 29 | Leap Year | - | - | - | $157,353 | 62 | $305,205 | Jun 25 | United International Pictures | false |
| 30 | Mammoth | - | - | - | $150,263 | 29 | $182,455 | Jun 4 | Golem Distribución | false |
| 31 | Brother and Sister | - | - | - | $140,266 | 35 | $219,010 | Jun 18 | Alta Films | false |
| 32 | The Back-up Plan | - | - | - | $128,768 | 370 | $2,482,690 | May 7 | Sony Pictures Releasing | false |
| 33 | Life Begins Today | - | - | - | $126,870 | 59 | $396,820 | Jun 25 | Filmax | false |
| 34 | Magic Journey to Africa | - | - | - | $119,002 | 181 | $1,070,844 | May 7 | Filmax | false |
| 35 | The Good Heart | - | - | - | $116,588 | 29 | $138,373 | Jun 4 | Alta Films | false |
| 36 | My Name Is Khan | - | - | - | $95,208 | 47 | $152,259 | May 28 | 20th Century Fox International | false |
| 37 | Rage | - | - | - | $82,335 | 48 | $145,524 | May 28 | Wanda Visión S.A. | false |
| 38 | Baaria | - | - | - | $80,919 | 55 | $272,207 | May 21 | TriPictures | false |
| 39 | Fashion Victim | - | - | - | $77,990 | 11 | $221,021 | May 14 | Alta Films | false |
| 40 | Everyone Else | - | - | - | $76,765 | 30 | $155,014 | Jun 25 | Karma Films | false |
| 41 | Death at a Funeral | - | - | - | $74,305 | 30 | $153,050 | Jun 25 | Sony Pictures Releasing | false |
| 42 | About Elly | - | - | - | $67,871 | 6 | $142,370 | May 21 | Golem Distribución | false |
| 43 | Oceans | - | - | - | $62,913 | 123 | $1,638,607 | Apr 23 | Notro Films | false |
| 44 | Air Doll | - | - | - | $51,323 | 18 | $93,106 | Jun 18 | Golem Distribución | false |
| 45 | For 80 Days | - | - | - | $50,765 | 14 | $115,251 | May 21 | Barton Films | false |
| 46 | Room in Rome | - | - | - | $36,682 | 126 | $687,413 | May 7 | Paramount Pictures International | false |
| 47 | The Cove | - | - | - | $36,097 | 13 | $44,844 | Jun 11 | - | false |
| 48 | When in Rome | - | - | - | $35,639 | 10 | $41,400 | Jun 18 | Walt Disney Pictures | false |
| 49 | The Girl on the Train | - | - | - | $33,517 | 7 | $97,117 | Jun 25 | Vértigo Films | false |
| 50 | Station of the Forgotten | - | - | - | $32,513 | 39 | $68,570 | Jun 4 | - | false |
| 51 | Dogtooth | - | - | - | $32,444 | 7 | $163,996 | May 14 | Karma Films | false |
| 52 | Soul Kitchen | - | - | - | $25,857 | 22 | $788,001 | Mar 31 | Golem Distribución | false |
| 53 | Solstorm 2010 Re-release | - | - | - | $24,641 | 8 | $59,571 | May 21 | Karma Films | false |
| 54 | Fish Tank | - | - | - | $14,229 | 35 | $282,878 | Apr 30 | Alta Films | false |
| 55 | Siempre hay tiempo | - | - | - | $14,005 | 24 | $82,447 | May 14 | - | false |
| 56 | The Maid | - | - | - | $13,658 | 10 | $196,272 | Apr 16 | Golem Distribución | false |
| 57 | Fantastic Mr. Fox | - | - | - | $12,757 | 30 | $136,634 | Apr 23 | 20th Century Fox International | false |
| 58 | The Island Inside | - | - | - | $12,537 | 43 | $317,155 | Apr 9 | Alta Films | false |
| 59 | Familystrip | - | - | - | $12,235 | 6 | $16,006 | May 28 | - | false |
| 60 | An Education | - | - | - | $12,136 | 61 | $1,308,337 | Feb 26 | Sony Pictures Releasing | false |
| 61 | El Regalo 2010 Re-release | - | - | - | $11,871 | 7 | $17,568 | Jun 18 | - | false |
| 62 | I, Don Giovanni | - | - | - | $7,371 | 9 | $28,904 | Jun 25 | - | false |
| 63 | Anvil: The Story of Anvil | - | - | - | $6,293 | 4 | $11,868 | Jun 25 | Avalon | false |
| 64 | Tulpan | - | - | - | $3,611 | 6 | $56,543 | Apr 16 | Karma Films | false |
| 65 | The Trap 2010 Re-release | - | - | - | $3,550 | 2 | $6,933 | May 28 | - | false |
| 66 | Finisterrae | - | - | - | $2,550 | 2 | $2,550 | Jun 11 | Golem Distribución | false |
| 67 | Reykjavik-Rotterdam 2010 Re-release | - | - | - | $2,544 | 4 | $22,472 | May 14 | - | false |
| 68 | The Bounty Hunter | - | - | - | $2,127 | 344 | $4,053,717 | Apr 9 | Sony Pictures Releasing | false |
| 69 | Mentiras piadosas | - | - | - | $1,684 | 4 | $18,262 | Apr 23 | - | false |
| 70 | Dear John | - | - | - | $1,088 | 210 | $2,590,323 | Mar 26 | Sony Pictures Releasing | false |
| 71 | Change Nothing | - | - | - | $1,087 | 2 | $4,432 | Jun 11 | - | false |
| 72 | La Luna En Ti | - | - | - | $1,069 | 3 | $1,069 | Jun 18 | Karma Films | false |
| 73 | Nausicaä of the Valley of the Wind 2010 Re-release | - | - | - | $945 | 4 | $39,306 | May 7 | Aurum Films | false |
| 74 | The Men Who Stare at Goats | - | - | - | $892 | 228 | $4,426,474 | Mar 5 | Sony Pictures Releasing | false |
| 75 | The Book of Eli | - | - | - | $538 | 304 | $5,069,500 | Mar 18 | Sony Pictures Releasing | false |
| 76 | Cloudy with a Chance of Meatballs | - | - | - | $408 | 491 | $7,000,967 | Dec 4 | Sony Pictures Releasing | false |
| 77 | The Last Summer of La Boyita | - | - | - | $221 | 4 | $11,322 | May 7 | Warner Bros. | false |
