| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Toy Story 3 | - | - | - | $5,430,352 | 177 | $16,026,307 | Jun 17 | Walt Disney Pictures | false |
| 2 | Prince of Persia: The Sands of Time | - | - | - | $2,017,706 | 99 | $3,101,060 | May 27 | Walt Disney Pictures | false |
| 3 | Sex and the City 2 | - | - | - | $1,117,575 | 82 | $1,188,295 | Jun 3 | Warner Bros. | false |
| 4 | Robin Hood | - | - | - | $753,293 | 116 | $2,992,530 | May 13 | Universal Pictures International (UPI) | false |
| 5 | Carancho | - | - | - | $690,352 | 67 | $2,525,489 | May 6 | Walt Disney Pictures | false |
| 6 | The Karate Kid | - | - | - | $283,254 | 80 | $917,488 | Jun 24 | Sony Pictures Releasing | false |
| 7 | Legion | - | - | - | $282,689 | 31 | $303,264 | Jun 3 | Sony Pictures Releasing | false |
| 8 | The Ghost Writer | - | - | - | $252,598 | 42 | $789,829 | May 13 | Alfa Films | false |
| 9 | Letters to Juliet | - | - | - | $229,653 | 17 | $398,187 | Jun 10 | Alfa Films | false |
| 10 | Garfield's Pet Force | - | - | - | $185,493 | 34 | $877,854 | May 13 | CDI Films | false |
| 11 | A Nightmare on Elm Street | - | - | - | $179,471 | 48 | $1,163,151 | May 6 | Warner Bros. | false |
| 12 | The A-Team | - | - | - | $146,113 | 60 | $325,161 | Jun 24 | 20th Century Fox International | false |
| 13 | The Road | - | - | - | $122,185 | 33 | $327,895 | Jun 24 | Distribution Company | false |
| 14 | New York, I Love You 2010 Re-release | - | - | - | $111,150 | 16 | $137,848 | Jun 17 | Alfa Films | false |
| 15 | Marmaduke | - | - | - | $109,362 | 31 | $201,229 | May 27 | 20th Century Fox International | false |
| 16 | The Back-up Plan | - | - | - | $102,827 | 31 | $291,820 | May 20 | Sony Pictures Releasing | false |
| 17 | The Last Song | - | - | - | $83,279 | 13 | $93,017 | Jun 10 | Walt Disney Pictures | false |
| 18 | Iron Man 2 | - | - | - | $83,101 | 101 | $2,566,778 | Apr 29 | Paramount Pictures International | false |
| 19 | Hachi: A Dog's Tale | - | - | - | $75,577 | 36 | $312,385 | May 20 | - | false |
| 20 | Kick-Ass | - | - | - | $72,510 | 32 | $75,186 | Jun 10 | Universal Pictures International (UPI) | false |
| 21 | Brideshead Revisited | - | - | - | $59,540 | 9 | $96,499 | May 27 | Impacto Cine | false |
| 22 | It's Your Fault | - | - | - | $46,288 | 12 | $51,098 | Jun 3 | Primer Plano Film Group | false |
| 23 | El mural | - | - | - | $40,185 | 21 | $137,066 | May 20 | - | false |
| 24 | Battle for Terra | - | - | - | $30,236 | 32 | $81,176 | May 27 | Distribution Company | false |
| 25 | Clash of the Titans | - | - | - | $24,173 | 114 | $3,978,951 | Apr 15 | Warner Bros. | false |
| 26 | The Hush 2010 Re-release | - | - | - | $23,250 | 4 | $31,743 | Jun 17 | - | false |
| 27 | France | - | - | - | $22,033 | 12 | $31,319 | Jun 17 | Primer Plano Film Group | false |
| 28 | Stella | - | - | - | $17,944 | 6 | $17,944 | Jun 3 | Primer Plano Film Group | false |
| 29 | Treeless Mountain | - | - | - | $17,564 | 5 | $17,564 | Jun 10 | IFA | false |
| 30 | Brooklyn's Finest 2010 Re-release | - | - | - | $13,526 | 48 | $172,005 | May 20 | Distribution Company | false |
| 31 | The White Ribbon | - | - | - | $11,031 | 15 | $180,975 | Apr 22 | - | false |
| 32 | It's Alive | - | - | - | $10,238 | 21 | $118,181 | Apr 22 | Distribution Company | false |
| 33 | Flame & Citron | - | - | - | $10,080 | 5 | $26,349 | Jun 24 | - | false |
| 34 | Traviata | - | - | - | $6,950 | 12 | $6,950 | Jun 10 | - | false |
| 35 | Hadewijch | - | - | - | $6,462 | 4 | $25,715 | May 20 | CDI Films | false |
| 36 | The Beaches of Agnès | - | - | - | $3,662 | 8 | $65,961 | Apr 29 | IFA | false |
| 37 | Remember Me | - | - | - | $3,390 | 29 | $305,441 | Apr 8 | Alfa Films | false |
| 38 | Piano Mudo | - | - | - | $2,933 | 4 | $2,933 | Jun 10 | - | false |
| 39 | Eva and Lola | - | - | - | $2,155 | 10 | $15,452 | May 13 | Primer Plano Film Group | false |
| 40 | The Men Who Stare at Goats | - | - | - | $2,050 | 30 | $195,188 | Apr 22 | Sony Pictures Releasing | false |
| 41 | The Box | - | - | - | $1,744 | 18 | $75,812 | Apr 15 | Alfa Films | false |
| 42 | Jerichow | - | - | - | $1,698 | 4 | $15,705 | May 20 | Alfa Films | false |
| 43 | Dear John | - | - | - | $1,020 | 30 | $69,939 | Apr 15 | Sony Pictures Releasing | false |
| 44 | Gods 2010 Re-release | - | - | - | $834 | 1 | $1,389 | May 27 | - | false |
| 45 | The Bounty Hunter | - | - | - | $731 | 43 | $344,433 | Apr 1 | Sony Pictures Releasing | false |
