| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Up | - | - | - | $4,889,193 | 89 | $7,249,646 | Jun 5 | Walt Disney Pictures | false |
| 2 | Terminator Salvation | - | - | - | $2,329,693 | 85 | $2,679,579 | Jun 4 | Sony Pictures Releasing | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $1,919,780 | 82 | $4,372,866 | May 22 | 20th Century Fox International | false |
| 4 | Angels & Demons | - | - | - | $1,509,836 | 89 | $4,444,803 | May 15 | Sony Pictures Releasing | false |
| 5 | The Unborn | - | - | - | $1,027,898 | 45 | $1,620,599 | Jun 12 | United International Pictures | false |
| 6 | Transformers: Revenge of the Fallen | - | - | - | $774,133 | 58 | $4,030,620 | Jun 26 | United International Pictures | false |
| 7 | Knowing | - | - | - | $578,074 | 41 | $817,528 | May 29 | - | false |
| 8 | Duplicity | - | - | - | $350,186 | 36 | $613,906 | Jun 19 | United International Pictures | false |
| 9 | Race to Witch Mountain | - | - | - | $192,040 | 40 | $1,838,367 | May 1 | Walt Disney Pictures | false |
| 10 | Flawless | - | - | - | $131,315 | 12 | $213,503 | May 29 | - | false |
| 11 | War | - | - | - | $128,621 | 20 | $233,319 | Jun 19 | - | false |
| 12 | Traitor | - | - | - | $116,742 | 23 | $135,340 | Jun 12 | - | false |
| 13 | In Bruges | - | - | - | $69,721 | 10 | $168,442 | Jun 19 | - | false |
| 14 | The Accidental Husband | - | - | - | $69,065 | 26 | $505,288 | May 15 | Walt Disney Pictures | false |
| 15 | Paris, Je T'aime | - | - | - | $53,890 | 5 | $135,749 | May 15 | - | false |
| 16 | X-Men Origins: Wolverine | - | - | - | $50,514 | 72 | $2,524,914 | Apr 30 | 20th Century Fox International | false |
| 17 | Impy's Island | - | - | - | $48,483 | 17 | $221,323 | Jun 26 | - | false |
| 18 | Swing Vote | - | - | - | $47,557 | 10 | $92,837 | May 29 | - | false |
| 19 | Solstice | - | - | - | $39,288 | 15 | $248,308 | May 22 | - | false |
| 20 | The Diving Bell and the Butterfly | - | - | - | $26,888 | 3 | $68,100 | May 22 | - | false |
| 21 | The Air I Breathe | - | - | - | $24,145 | 9 | $107,013 | Jun 26 | - | false |
| 22 | Coraline | - | - | - | $21,472 | 37 | $545,266 | May 6 | United International Pictures | false |
| 23 | Star Trek | - | - | - | $15,828 | 45 | $568,721 | May 8 | United International Pictures | false |
| 24 | Earth | - | - | - | $15,625 | 11 | $367,734 | Apr 24 | Walt Disney Pictures | false |
| 25 | Fast & Furious | - | - | - | $11,538 | 65 | $4,604,144 | Apr 3 | United International Pictures | false |
| 26 | Swing con son | - | - | - | $10,271 | 9 | $79,165 | Apr 24 | - | false |
| 27 | The Strangers | - | - | - | $7,889 | 23 | $485,189 | Apr 24 | - | false |
| 28 | He's Just Not That Into You | - | - | - | $6,816 | 27 | $513,899 | May 1 | - | false |
| 29 | Slumdog Millionaire | - | - | - | $4,055 | 27 | $1,748,182 | Feb 27 | - | false |
| 30 | The Pope's Toilet | - | - | - | $2,306 | 3 | $4,366 | May 29 | - | false |
| 31 | Inkheart | - | - | - | $2,128 | 26 | $953,627 | Mar 27 | - | false |
| 32 | Monsters vs. Aliens | - | - | - | $1,816 | 81 | $3,033,291 | Apr 3 | United International Pictures | false |
