| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $4,952,165 | 818 | $26,775,811 | May 13 | Sony Pictures Releasing | false |
| 2 | Night at the Museum: Battle of the Smithsonian | - | - | - | $4,777,176 | 518 | $9,988,389 | May 22 | 20th Century Fox International | false |
| 3 | Terminator Salvation | - | - | - | $4,741,777 | 516 | $4,952,079 | Jun 5 | Sony Pictures Releasing | false |
| 4 | Transformers: Revenge of the Fallen | - | - | - | $4,324,077 | 578 | $11,685,751 | Jun 26 | United International Pictures | false |
| 5 | Un'estate ai Caraibi | - | - | - | $4,135,555 | 545 | $5,311,857 | Jun 12 | Medusa Distribuzione | false |
| 6 | The Girl with the Dragon Tattoo | - | - | - | $3,205,071 | 437 | $5,295,520 | May 29 | BIM Distribuzione | false |
| 7 | Coraline | - | - | - | $2,690,187 | 205 | $4,957,811 | Jun 19 | United International Pictures | false |
| 8 | The Hangover | - | - | - | $2,057,825 | 292 | $5,950,032 | Jun 19 | Warner Bros. | false |
| 9 | Coco Before Chanel | - | - | - | $1,192,017 | 164 | $1,792,873 | May 29 | Warner Bros. | false |
| 10 | Vincere | - | - | - | $1,178,505 | 302 | $2,991,766 | May 20 | 01 Distribution | false |
| 11 | My Best Friend's Girl | - | - | - | $975,015 | 150 | $1,537,633 | Jun 19 | Eagle Pictures | false |
| 12 | My Bloody Valentine | - | - | - | $758,782 | 278 | $8,725,914 | May 8 | Medusa Distribuzione | false |
| 13 | The Secret of Moonacre | - | - | - | $758,294 | 176 | $817,253 | Jun 12 | - | false |
| 14 | The Boat That Rocked | - | - | - | $531,235 | 99 | $1,383,446 | Jun 12 | United International Pictures | false |
| 15 | Cash | - | - | - | $495,658 | 136 | $495,658 | Jun 5 | - | false |
| 16 | 17 Again | - | - | - | $399,162 | 328 | $2,211,411 | May 15 | Warner Bros. | false |
| 17 | Antichrist | - | - | - | $265,522 | 121 | $707,717 | May 22 | Lucky Red | false |
| 18 | Borderland | - | - | - | $214,325 | 89 | $238,952 | Jun 19 | Sony Pictures Releasing | false |
| 19 | Battle for Terra | - | - | - | $179,057 | 130 | $297,695 | May 29 | Sony Pictures Releasing | false |
| 20 | State of Play | - | - | - | $148,295 | 301 | $3,559,324 | Apr 30 | United International Pictures | false |
| 21 | Filth and Wisdom | - | - | - | $137,841 | 72 | $159,288 | Jun 12 | Sacher Distribuzione | false |
| 22 | Questione di cuore | - | - | - | $133,905 | 264 | $3,919,677 | Apr 17 | 01 Distribution | false |
| 23 | Star Trek | - | - | - | $114,273 | 327 | $3,127,646 | May 8 | United International Pictures | false |
| 24 | Cloud 9 | - | - | - | $108,587 | 17 | $145,980 | May 29 | Warner Bros. | false |
| 25 | Martyrs | - | - | - | $106,200 | 58 | $106,200 | Jun 12 | - | false |
| 26 | L'amour | - | - | - | $101,729 | 13 | $115,874 | Jun 5 | - | false |
| 27 | Fist of the North Star: The Legends of the True Savior: Legend of Raoh-Chapter of Death in Love 2008 Re-release | - | - | - | $99,004 | 56 | $26,568 | Jul 4 | Mikado Film | false |
| 28 | Love and Other Crimes | - | - | - | $77,184 | 34 | $114,745 | Jun 19 | - | false |
| 29 | Visions | - | - | - | $63,937 | - | $63,937 | Jun 5 | - | false |
| 30 | Look Both Ways 2009 Re-release | - | - | - | $57,313 | 20 | $96,022 | Jun 19 | Fandango | false |
| 31 | Crossing Over | - | - | - | $56,562 | 30 | $156,371 | Jun 26 | 01 Distribution | false |
| 32 | O'Horten | - | - | - | $56,412 | 17 | $106,699 | Jun 19 | - | false |
| 33 | Destiny Ride 2009 Re-release | - | - | - | $55,687 | - | $55,687 | Jun 26 | - | false |
| 34 | The Milk of Sorrow | - | - | - | $45,789 | 35 | $259,256 | May 8 | - | false |
| 35 | Gran Torino | - | - | - | $39,060 | 332 | $12,993,866 | Mar 13 | Warner Bros. | false |
| 36 | Brideshead Revisited | - | - | - | $18,509 | 15 | $71,921 | Jun 26 | Walt Disney Pictures | false |
| 37 | Garage | - | - | - | $17,958 | 8 | $98,340 | Jun 5 | - | false |
| 38 | Two Lovers | - | - | - | $15,436 | 108 | $1,339,026 | Mar 27 | BIM Distribuzione | false |
| 39 | The Tale of Despereaux | - | - | - | $12,779 | 103 | $645,683 | Apr 24 | United International Pictures | false |
| 40 | The Great Alibi | - | - | - | $12,631 | 5 | $72,513 | Jun 5 | Medusa Distribuzione | false |
| 41 | Anamorph | - | - | - | $9,432 | 11 | $131,277 | Jun 26 | Eagle Pictures | false |
| 42 | Earth | - | - | - | $8,771 | 87 | $1,046,151 | Apr 22 | Walt Disney Pictures | false |
| 43 | Transformers | - | - | - | $6,298 | 574 | $11,301,608 | Jun 28 | United International Pictures | false |
| 44 | Louise hires a contract killer | - | - | - | $5,352 | 48 | $803,171 | Apr 3 | Fandango | false |
| 45 | Cadillac Records | - | - | - | $1,164 | 2 | $22,053 | May 29 | Sony Pictures Releasing | false |
