| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Up | - | - | - | $1,995,936 | 74 | $3,645,572 | Jun 11 | Walt Disney Pictures | false |
| 2 | Terminator Salvation | - | - | - | $870,979 | 53 | $948,216 | Jun 4 | Sony Pictures Releasing | false |
| 3 | Transformers: Revenge of the Fallen | - | - | - | $566,091 | 84 | $2,047,357 | Jun 23 | United International Pictures | false |
| 4 | Angels & Demons | - | - | - | $498,564 | 73 | $2,211,285 | May 14 | Sony Pictures Releasing | false |
| 5 | Night at the Museum: Battle of the Smithsonian | - | - | - | $462,233 | 71 | $1,381,208 | May 21 | 20th Century Fox International | false |
| 6 | Knowing | - | - | - | $315,175 | 33 | $715,344 | May 21 | - | false |
| 7 | Hannah Montana: The Movie | - | - | - | $84,737 | 40 | $1,056,206 | Apr 30 | Walt Disney Pictures | false |
| 8 | Duplicity | - | - | - | $81,242 | 21 | $144,527 | May 28 | United International Pictures | false |
| 9 | The Accidental Husband | - | - | - | $45,833 | 25 | $55,410 | Jun 18 | Walt Disney Pictures | false |
| 10 | X-Men Origins: Wolverine | - | - | - | $45,139 | 64 | $993,660 | Apr 30 | 20th Century Fox International | false |
| 11 | Fast & Furious | - | - | - | $30,196 | 32 | $344,211 | May 7 | United International Pictures | false |
| 12 | Monsters vs. Aliens | - | - | - | $29,100 | 79 | $1,036,375 | Apr 2 | United International Pictures | false |
| 13 | Earth | - | - | - | $27,786 | 20 | $372,880 | Apr 22 | Walt Disney Pictures | false |
| 14 | Star Trek | - | - | - | $26,152 | 30 | $273,992 | May 7 | United International Pictures | false |
| 15 | Paris | - | - | - | $24,657 | 5 | $90,990 | May 7 | - | false |
| 16 | Gomorrah | - | - | - | $20,403 | 14 | $39,643 | May 28 | Transeuropa | false |
| 17 | Blackout 2009 Re-release | - | - | - | $19,423 | 8 | $23,460 | Jun 18 | - | false |
| 18 | Push | - | - | - | $18,537 | 12 | $18,537 | - | - | false |
| 19 | Vicky Cristina Barcelona | - | - | - | $18,320 | 20 | $220,130 | Apr 30 | - | false |
| 20 | Teresa: Crucificada por amar | - | - | - | $15,081 | 9 | $66,639 | Jun 18 | - | false |
| 21 | Be Kind Rewind | - | - | - | $11,456 | 8 | $11,456 | Jun 4 | - | false |
| 22 | Ghosts of Girlfriends Past | - | - | - | $10,793 | 17 | $85,301 | May 14 | Warner Bros. | false |
| 23 | Race to Witch Mountain | - | - | - | $8,351 | 36 | $674,840 | Apr 9 | Walt Disney Pictures | false |
| 24 | Bonneville | - | - | - | $7,453 | 4 | $7,453 | Jun 4 | - | false |
| 25 | Grace Is Gone | - | - | - | $5,769 | 2 | $9,181 | Jun 25 | - | false |
| 26 | 17 Again | - | - | - | $4,028 | 22 | $136,867 | Apr 23 | Warner Bros. | false |
| 27 | My Mom's New Boyfriend | - | - | - | $2,016 | 4 | $7,120 | May 28 | Andes Films | false |
