| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Up | - | - | - | $2,519,512 | 129 | $3,428,922 | Jun 11 | Walt Disney Pictures | false |
| 2 | Terminator Salvation | - | - | - | $1,882,270 | 152 | $1,978,108 | Jun 3 | Sony Pictures Releasing | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $937,968 | 115 | $2,537,926 | May 21 | 20th Century Fox International | false |
| 4 | Angels & Demons | - | - | - | $904,706 | 161 | $3,330,559 | May 14 | Sony Pictures Releasing | false |
| 5 | Transformers: Revenge of the Fallen | - | - | - | $863,164 | 119 | $2,491,004 | Jun 25 | Paramount Pictures International | false |
| 6 | Last Chance Harvey | - | - | - | $401,926 | 22 | $472,455 | Jun 4 | Distribution Company | false |
| 7 | Ghosts of Girlfriends Past | - | - | - | $371,428 | 42 | $459,308 | Jun 11 | Distribution Company | false |
| 8 | State of Play | - | - | - | $361,845 | 35 | $534,391 | Jun 11 | Universal Pictures International (UPI) | false |
| 9 | The Unborn | - | - | - | $345,933 | 36 | $776,427 | May 21 | Universal Pictures International (UPI) | false |
| 10 | Felicitas | - | - | - | $336,043 | 35 | $448,232 | Jun 11 | Pachamama Cine | false |
| 11 | New in Town | - | - | - | $152,480 | 31 | $262,520 | May 28 | Distribution Company | false |
| 12 | Inspector Bellamy | - | - | - | $133,501 | 14 | $140,116 | Jun 4 | Alfa Films | false |
| 13 | The Reader | - | - | - | $103,096 | 35 | $570,036 | May 7 | Pachamama Cine | false |
| 14 | Jonas Brothers: The 3D Concert Experience | - | - | - | $93,663 | 14 | $313,395 | May 22 | Walt Disney Pictures | false |
| 15 | Happy-Go-Lucky | - | - | - | $92,864 | 20 | $129,233 | Jun 18 | - | false |
| 16 | The Visitor | - | - | - | $78,820 | 15 | $112,320 | Jun 18 | Impacto Cine | false |
| 17 | Pride and Glory | - | - | - | $57,293 | 22 | $133,700 | Jun 25 | Distribution Company | false |
| 18 | Earth | - | - | - | $45,827 | 31 | $480,164 | Apr 22 | Walt Disney Pictures | false |
| 19 | Che: Part Two | - | - | - | $41,973 | 19 | $53,193 | Jun 18 | Alfa Films | false |
| 20 | Adventureland | - | - | - | $34,326 | 10 | $34,326 | Jun 4 | Walt Disney Pictures | false |
| 21 | X-Men Origins: Wolverine | - | - | - | $28,971 | 112 | $1,725,740 | Apr 30 | 20th Century Fox International | false |
| 22 | Duplicity | - | - | - | $26,201 | 41 | $587,482 | Apr 23 | Universal Pictures International (UPI) | false |
| 23 | Race to Witch Mountain | - | - | - | $23,068 | 48 | $966,504 | Apr 9 | Walt Disney Pictures | false |
| 24 | Star Trek | - | - | - | $18,589 | 50 | $403,172 | May 7 | Paramount Pictures International | false |
| 25 | 17 Again | - | - | - | $18,507 | 47 | $421,582 | May 7 | Distribution Company | false |
| 26 | A Week Alone | - | - | - | $14,746 | 5 | $17,640 | Jun 11 | Primer Plano Film Group | false |
| 27 | Lorna's Silence | - | - | - | $14,739 | 8 | $91,085 | May 14 | Distribution Company | false |
| 28 | The Roses of the Desert 2009 Re-release | - | - | - | $14,365 | 4 | $18,306 | Jun 11 | Primer Plano Film Group | false |
| 29 | Gardens in Autumn 2008 Re-release | - | - | - | $13,752 | 7 | $82,676 | Apr 30 | IFA | false |
| 30 | All the Lonely People | - | - | - | $13,114 | 13 | $18,319 | Jun 18 | Primer Plano Film Group | false |
| 31 | The Artist | - | - | - | $12,906 | 5 | $26,090 | May 28 | Primer Plano Film Group | false |
| 32 | The Merry Widow | - | - | - | $9,044 | 14 | $151,596 | Apr 16 | Alfa Films | false |
| 33 | The Accidental Husband | - | - | - | $7,435 | 35 | $225,379 | Apr 30 | Walt Disney Pictures | false |
| 34 | The Class | - | - | - | $7,364 | 21 | $301,798 | Apr 16 | Primer Plano Film Group | false |
| 35 | Haroldo Conti, homo viator | - | - | - | $5,706 | 3 | $5,899 | May 28 | - | false |
| 36 | Fast & Furious | - | - | - | $4,654 | 48 | $1,901,922 | Apr 2 | Universal Pictures International (UPI) | false |
| 37 | Blood Appears | - | - | - | $4,490 | 6 | $25,911 | May 14 | - | false |
| 38 | Chef's Special 2009 Re-release | - | - | - | $3,248 | 13 | $16,498 | May 28 | Alfa Films | false |
| 39 | Days of May | - | - | - | $2,685 | 5 | $17,291 | May 21 | Primer Plano Film Group | false |
| 40 | Luisa | - | - | - | $2,086 | 9 | $14,253 | May 7 | Primer Plano Film Group | false |
| 41 | Then She Found Me | - | - | - | $2,042 | 20 | $77,002 | Apr 30 | Distribution Company | false |
| 42 | A Thousand Years of Good Prayers | - | - | - | $1,282 | 5 | $10,685 | May 21 | Primer Plano Film Group | false |
| 43 | Mundo alas | - | - | - | $1,017 | 8 | $35,429 | Mar 26 | Distribution Company | false |
| 44 | Rumba | - | - | - | $438 | 9 | $67,362 | Apr 2 | Distribution Company | false |
| 45 | The Edge of Heaven | - | - | - | $370 | 13 | $155,500 | Mar 19 | Alfa Films | false |
| 46 | Bolt | - | - | - | $66 | 121 | $2,103,777 | Jan 15 | Walt Disney Pictures | false |
| 47 | The 100 Days That Didn't Shake the World | - | - | - | $18 | 1 | $806 | May 28 | Primer Plano Film Group | false |
