| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Sex and the City | - | - | - | $7,589,275 | 552 | $9,817,656 | May 30 | 01 Distribution | false |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $6,386,722 | 689 | $18,982,360 | May 23 | Universal Pictures International (UPI) | false |
| 3 | Gomorrah | - | - | - | $4,858,469 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 4 | Il Divo | - | - | - | $4,623,274 | 358 | $8,517,653 | May 28 | Lucky Red | false |
| 5 | The Incredible Hulk | - | - | - | $3,494,887 | 477 | $6,460,290 | Jun 18 | Universal Pictures International (UPI) | false |
| 6 | The Happening | - | - | - | $3,216,780 | 363 | $3,877,389 | Jun 12 | 20th Century Fox International | false |
| 7 | Made of Honor | - | - | - | $2,319,507 | 293 | $2,337,688 | Jun 12 | Sony Pictures Releasing | false |
| 8 | Un'estate al mare | - | - | - | $2,061,872 | 576 | $7,770,731 | Jun 27 | Medusa Distribuzione | false |
| 9 | Then She Found Me | - | - | - | $917,282 | 142 | $940,111 | Jun 6 | Medusa Distribuzione | false |
| 10 | Superhero Movie | - | - | - | $702,552 | 362 | $4,416,797 | May 16 | Medusa Distribuzione | false |
| 11 | One Missed Call | - | - | - | $696,248 | 109 | $747,957 | Jun 4 | Warner Bros. | false |
| 12 | The Hitcher | - | - | - | $688,175 | 205 | $1,092,472 | May 30 | Medusa Distribuzione | false |
| 13 | What Happens in Vegas | - | - | - | $548,422 | 295 | $5,188,588 | May 9 | 20th Century Fox International | false |
| 14 | Once | - | - | - | $436,461 | 35 | $746,500 | May 30 | Sacher Distribuzione | false |
| 15 | Iron Man | - | - | - | $367,267 | 509 | $10,809,921 | May 1 | Universal Pictures International (UPI) | false |
| 16 | Things We Lost in the Fire | - | - | - | $343,694 | 97 | $414,156 | Jun 12 | Teodora Film | false |
| 17 | Street Kings | - | - | - | $343,037 | 247 | $898,198 | Jun 27 | 20th Century Fox International | false |
| 18 | Wild Blood | - | - | - | $305,405 | 215 | $932,866 | May 23 | 01 Distribution | false |
| 19 | The Year My Parents Went on Vacation | - | - | - | $252,296 | 27 | $384,887 | Jun 6 | Lucky Red | false |
| 20 | Feel the Noise | - | - | - | $241,626 | 118 | $244,011 | Jun 13 | Mediafilm | false |
| 21 | Gardener of Eden | - | - | - | $225,385 | 42 | $225,385 | Jun 20 | Medusa Distribuzione | false |
| 22 | Elite Squad | - | - | - | $211,442 | 56 | $228,296 | Jun 6 | Mikado Film | false |
| 23 | The Rest of the Night 2008 Re-release | - | - | - | $193,588 | 61 | $282,009 | Jun 11 | 01 Distribution | false |
| 24 | Bratz | - | - | - | $150,460 | 149 | $150,460 | Jun 6 | Eagle Pictures | false |
| 25 | Leatherheads | - | - | - | $147,537 | 218 | $3,763,108 | Apr 11 | Universal Pictures International (UPI) | false |
| 26 | Unknown | - | - | - | $140,520 | 24 | $140,520 | Jun 20 | Eagle Pictures | false |
| 27 | Horton Hears a Who! | - | - | - | $134,398 | 463 | $3,958,990 | Apr 18 | 20th Century Fox International | false |
| 28 | Go Go Tales | - | - | - | $127,212 | 110 | $849,766 | Jun 20 | Mediafilm | false |
| 29 | Mongol: The Rise of Genghis Khan | - | - | - | $118,656 | 137 | $1,325,000 | May 9 | BIM Distribuzione | false |
| 30 | The Darjeeling Limited | - | - | - | $115,183 | 70 | $1,237,762 | Apr 30 | 20th Century Fox International | false |
| 31 | Maradona by Kusturica | - | - | - | $106,296 | 82 | $160,690 | May 30 | BIM Distribuzione | false |
| 32 | In Bruges | - | - | - | $91,438 | 151 | $772,903 | May 16 | Mikado Film | false |
| 33 | The Other Boleyn Girl | - | - | - | $91,154 | 102 | $2,180,712 | Apr 24 | Universal Pictures International (UPI) | false |
| 34 | Full of It | - | - | - | $89,577 | 29 | $89,878 | Jun 13 | Warner Bros. | false |
| 35 | The Kite Runner | - | - | - | $77,384 | 371 | $12,730,140 | Mar 28 | Filmauro | false |
| 36 | The Girl by the Lake | - | - | - | $71,650 | 143 | $4,688,666 | Sep 14 | Medusa Distribuzione | false |
| 37 | Non pensarci | - | - | - | $64,150 | 222 | $2,239,655 | Apr 4 | 01 Distribution | false |
| 38 | Tuttifrutti | - | - | - | $62,307 | 21 | $103,007 | May 16 | - | false |
| 39 | Before the Devil Knows You're Dead | - | - | - | $56,347 | 277 | $4,648,889 | Mar 14 | Medusa Distribuzione | false |
| 40 | 21 | - | - | - | $49,226 | 247 | $3,927,213 | Apr 18 | Sony Pictures Releasing | false |
| 41 | The Ruins | - | - | - | $46,841 | 50 | $84,086 | Jun 27 | Universal Pictures International (UPI) | false |
| 42 | Be Kind Rewind | - | - | - | $46,507 | 95 | $220,443 | May 23 | BIM Distribuzione | false |
| 43 | Impy's Island | - | - | - | $46,295 | 131 | $177,467 | Jun 27 | Mediafilm | false |
| 44 | Alexandra | - | - | - | $43,554 | 7 | $77,404 | May 30 | - | false |
| 45 | The Early Bird Catches the Worm | - | - | - | $43,461 | 253 | $1,550,893 | Feb 29 | Medusa Distribuzione | false |
| 46 | The Night of the Sunflowers | - | - | - | $43,272 | 11 | $67,192 | Jun 13 | Istituto Luce | false |
| 47 | The Demons of St. Petersburg | - | - | - | $38,040 | 110 | $1,409,678 | Apr 24 | 01 Distribution | false |
| 48 | Woman's Hearts | - | - | - | $37,481 | 6 | $66,253 | Jun 13 | - | false |
| 49 | Ho ammazzato Berlusconi | - | - | - | $36,946 | 4 | $77,794 | Jun 20 | Independent Films | false |
| 50 | Savage Grace | - | - | - | $36,890 | 20 | $45,565 | Jun 20 | BIM Distribuzione | false |
| 51 | The Wind Blows Round | - | - | - | $35,840 | 15 | $659,151 | May 4 | Aranciafilm | false |
| 52 | Gli ultimi della strada | - | - | - | $34,850 | 252 | $1,062,945 | May 16 | 01 Distribution | false |
| 53 | Tutta la vita davanti | - | - | - | $31,407 | 368 | $5,648,340 | Mar 28 | Medusa Distribuzione | false |
| 54 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | - | - | - | $31,393 | 8 | $72,993 | Jun 20 | Walt Disney Pictures | false |
| 55 | Charlie Bartlett | - | - | - | $29,799 | 31 | $51,943 | May 30 | DNC Entertainment | false |
| 56 | Rise: Blood Hunter | - | - | - | $27,901 | 127 | $326,477 | May 23 | Eagle Pictures | false |
| 57 | 12 | - | - | - | $25,833 | 16 | $134,299 | Jun 27 | 01 Distribution | false |
| 58 | August Rush | - | - | - | $22,292 | 190 | $1,462,687 | Nov 30 | Medusa Distribuzione | false |
| 59 | Underdog | - | - | - | $20,801 | 15 | $74,430 | May 16 | Walt Disney Pictures | false |
| 60 | The Band's Visit | - | - | - | $20,230 | 51 | $919,800 | Mar 21 | Mikado Film | false |
| 61 | Don't Waste Your Time, Johnny! | - | - | - | $19,519 | 64 | $664,266 | Nov 30 | Medusa Distribuzione | false |
| 62 | Evening | - | - | - | $13,627 | 180 | $1,160,067 | Apr 24 | Medusa Distribuzione | false |
| 63 | Tutto torna | - | - | - | $11,263 | 8 | $84,447 | May 9 | - | false |
| 64 | Shall We Kiss? | - | - | - | $9,575 | 36 | $140,508 | May 9 | - | false |
| 65 | The Zone | - | - | - | $9,193 | 27 | $312,516 | Apr 4 | Sacher Distribuzione | false |
| 66 | When Darkness Falls 2008 Re-release | - | - | - | $8,594 | 31 | $218,530 | May 2 | Teodora Film | false |
| 67 | Italian Dream | - | - | - | $4,540 | 7 | $17,052 | Jun 27 | Lucky Red | false |
| 68 | Questa notte è ancora nostra | - | - | - | $2,771 | 399 | $5,201,233 | Mar 20 | Walt Disney Pictures | false |
| 69 | Sfiorarsi | - | - | - | $2,207 | 2 | $15,722 | Feb 23 | - | false |
| 70 | Carnera: The Walking Mountain | - | - | - | $1,792 | 244 | $408,793 | May 9 | Medusa Distribuzione | false |
| 71 | The Secret of the Grain | - | - | - | $1,516 | 79 | $2,875,013 | Jan 11 | Lucky Red | false |
| 72 | Days and Clouds | - | - | - | $1,456 | 214 | $6,010,383 | Oct 26 | Warner Bros. | false |
| 73 | Love Is Not Enough | - | - | - | $1,328 | 76 | $698,276 | Apr 18 | Mediafilm | false |
| 74 | Chiamami Salomè | - | - | - | $1,271 | 6 | $57,999 | May 9 | Mediaplex | false |
| 75 | There Will Be Blood | - | - | - | $889 | 111 | $2,566,966 | Feb 15 | Walt Disney Pictures | false |
| 76 | Gone Baby Gone | - | - | - | $879 | 16 | $115,103 | Apr 4 | Walt Disney Pictures | false |
| 77 | Speed Racer | - | - | - | $863 | 396 | $756,653 | May 9 | Warner Bros. | false |
| 78 | No Country for Old Men | - | - | - | $829 | 308 | $8,979,650 | Feb 22 | Universal Pictures International (UPI) | false |
