| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $8,828,185 | 732 | $32,751,799 | May 22 | Universal Pictures International (UPI) | false |
| 2 | The Happening | - | - | - | $6,779,353 | 387 | $9,690,746 | Jun 13 | 20th Century Fox International | false |
| 3 | The Incredible Hulk | - | - | - | $4,573,453 | 557 | $7,693,842 | Jun 20 | Sony Pictures Releasing | false |
| 4 | Sex and the City | - | - | - | $4,182,715 | 359 | $9,740,001 | Jun 20 | TriPictures | false |
| 5 | Made of Honor | - | - | - | $3,517,109 | 330 | $6,390,277 | May 30 | Sony Pictures Releasing | false |
| 6 | The Mist | - | - | - | $1,997,888 | 272 | $3,502,124 | May 30 | Notro Films | false |
| 7 | What Happens in Vegas | - | - | - | $1,733,038 | 408 | $11,838,452 | May 9 | 20th Century Fox International | false |
| 8 | Before the Devil Knows You're Dead | - | - | - | $1,399,357 | 106 | $3,620,899 | May 23 | Baditri | false |
| 9 | Leatherheads | - | - | - | $888,551 | 127 | $942,364 | Jun 6 | Universal Pictures International (UPI) | false |
| 10 | Emotional Arithmetic | - | - | - | $637,459 | 43 | $867,310 | Jun 6 | Golem Distribución | false |
| 11 | Forgetting Sarah Marshall | - | - | - | $613,538 | 252 | $2,542,955 | Jun 27 | Universal Pictures International (UPI) | false |
| 12 | Chef's Special | - | - | - | $558,033 | 232 | $7,819,057 | Apr 11 | Warner Bros. | false |
| 13 | 88 Minutes | - | - | - | $552,983 | 171 | $3,919,422 | Apr 30 | Filmax | false |
| 14 | Iron Man | - | - | - | $505,425 | 559 | $12,030,026 | Apr 30 | Sony Pictures Releasing | false |
| 15 | The Ugly Duckling and Me! | - | - | - | $487,349 | 148 | $1,034,649 | Jun 20 | Filmax | false |
| 16 | Prom Night | - | - | - | $379,474 | 228 | $1,873,142 | May 14 | Sony Pictures Releasing | false |
| 17 | Elegy | - | - | - | $329,684 | 128 | $3,914,620 | Apr 18 | On Pictures | false |
| 18 | Rivales | - | - | - | $313,300 | 245 | $1,019,451 | Jun 27 | - | false |
| 19 | Pretextos | - | - | - | $278,350 | 49 | $327,804 | Jun 13 | Golem Distribución | false |
| 20 | Death Sentence | - | - | - | $261,991 | 139 | $1,263,144 | May 16 | TriPictures | false |
| 21 | 10,000 BC | - | - | - | $245,279 | 475 | $13,119,769 | Mar 7 | Warner Bros. | false |
| 22 | Quiet Chaos | - | - | - | $220,643 | 60 | $529,427 | Jun 20 | Alta Films | false |
| 23 | Street Kings | - | - | - | $189,334 | 302 | $4,185,842 | Apr 25 | 20th Century Fox International | false |
| 24 | Speed Racer | - | - | - | $187,766 | 427 | $2,048,700 | May 9 | Warner Bros. | false |
| 25 | 21 | - | - | - | $179,503 | 255 | $6,840,432 | Apr 11 | Sony Pictures Releasing | false |
| 26 | The Game Plan | - | - | - | $178,848 | 250 | $6,016,924 | Mar 28 | Walt Disney Pictures | false |
| 27 | Asterix at the Olympic Games | - | - | - | $172,396 | 385 | $9,181,000 | Feb 8 | TriPictures | false |
| 28 | Casual Day | - | - | - | $171,224 | 120 | $1,405,814 | May 9 | Walt Disney Pictures | false |
| 29 | Horton Hears a Who! | - | - | - | $170,409 | 476 | $11,301,036 | Mar 14 | 20th Century Fox International | false |
| 30 | Grace Is Gone | - | - | - | $164,855 | 38 | $198,182 | Jun 13 | Notro Films | false |
| 31 | An American Crime | - | - | - | $154,110 | 52 | $179,784 | Jun 13 | Filmax | false |
| 32 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | - | - | - | $152,673 | 13 | $223,112 | Jun 6 | Walt Disney Pictures | false |
| 33 | Margot at the Wedding | - | - | - | $150,695 | 24 | $337,639 | Jun 20 | Universal Pictures International (UPI) | false |
| 34 | Courthouse on Horseback | - | - | - | $142,936 | 17 | $335,160 | May 23 | Karma Films | false |
| 35 | 3:19 2008 Re-release | - | - | - | $136,036 | 79 | $232,963 | Jun 20 | - | false |
| 36 | Sultanes del Sur | - | - | - | $126,956 | 113 | $277,041 | May 16 | Filmax | false |
| 37 | The Spiderwick Chronicles | - | - | - | $124,490 | 291 | $5,532,022 | Mar 14 | Universal Pictures International (UPI) | false |
| 38 | Island of Lost Souls | - | - | - | $115,612 | 59 | $408,900 | May 16 | Flins & Piniculas | false |
| 39 | Timecrimes | - | - | - | $111,066 | 77 | $389,919 | Jun 27 | - | false |
| 40 | A Thousand Years of Good Prayers | - | - | - | $110,277 | 337 | $1,163,809 | Apr 18 | Karma Films | false |
| 41 | A Girl Cut in Two | - | - | - | $105,228 | 39 | $493,500 | May 16 | Wanda Visión S.A. | false |
| 42 | Late Bloomers | - | - | - | $99,116 | 18 | $416,081 | May 9 | Yedra Films | false |
| 43 | 12 | - | - | - | $98,568 | 53 | $98,568 | Jun 13 | Flins & Piniculas | false |
| 44 | Drillbit Taylor | - | - | - | $89,807 | 112 | $406,806 | May 16 | Universal Pictures International (UPI) | false |
| 45 | The Dead Girl | - | - | - | $87,244 | 32 | $157,952 | May 30 | Filmax | false |
| 46 | Rudy: The Return of the Racing Pig | - | - | - | $82,666 | 64 | $407,216 | Apr 25 | Flins & Piniculas | false |
| 47 | The Edge of Heaven | - | - | - | $80,123 | 33 | $1,340,082 | Mar 14 | Golem Distribución | false |
| 48 | We Own the Night | - | - | - | $63,718 | 224 | $3,742,720 | Mar 28 | Universal Pictures International (UPI) | false |
| 49 | The Counterfeiters | - | - | - | $63,061 | 119 | $3,871,085 | Mar 14 | Wanda Visión S.A. | false |
| 50 | Alexandra | - | - | - | $58,789 | 8 | $93,587 | May 30 | Sagrera TV | false |
| 51 | The Water Horse | - | - | - | $53,666 | 205 | $3,438,882 | Mar 7 | Sony Pictures Releasing | false |
| 52 | Lars and the Real Girl | - | - | - | $52,034 | 21 | $287,503 | Apr 25 | Versus Entertainment | false |
| 53 | Be Kind Rewind | - | - | - | $47,834 | 32 | $561,516 | Apr 11 | Universal Pictures International (UPI) | false |
| 54 | 8 Dates | - | - | - | $44,373 | 171 | $1,354,462 | Apr 18 | Alta Films | false |
| 55 | The Savages | - | - | - | $44,059 | 48 | $989,819 | Apr 4 | 20th Century Fox International | false |
| 56 | Fool's Gold | - | - | - | $43,391 | 272 | $2,959,860 | Apr 25 | Warner Bros. | false |
| 57 | Cowards | - | - | - | $42,634 | 251 | $1,528,988 | Apr 25 | Filmax | false |
| 58 | The Contract | - | - | - | $38,091 | 121 | $1,885,696 | Apr 4 | Filmax | false |
| 59 | Caramel | - | - | - | $33,295 | 60 | $1,848,875 | Jan 18 | Alta Films | false |
| 60 | Shutter | - | - | - | $33,041 | 300 | $3,782,211 | Apr 11 | 20th Century Fox International | false |
| 61 | Encarnacion | - | - | - | $30,795 | 5 | $32,869 | Jun 6 | Wanda Visión S.A. | false |
| 62 | Nightwatching | - | - | - | $29,084 | 5 | $74,363 | May 30 | Manga Entertainment | false |
| 63 | My Mom's New Boyfriend | - | - | - | $28,094 | 202 | $1,324,291 | Apr 30 | DeAPlaneta | false |
| 64 | Bab'Aziz: The Prince That Contemplated His Soul | - | - | - | $27,937 | 6 | $257,291 | Mar 7 | Karma Films | false |
| 65 | The Band's Visit | - | - | - | $26,708 | 27 | $462,560 | Apr 11 | Manga Entertainment | false |
| 66 | The Ruins | - | - | - | $26,021 | 200 | $787,302 | Apr 18 | Universal Pictures International (UPI) | false |
| 67 | The Yacoubian Building | - | - | - | $26,003 | 2 | $58,770 | May 30 | Barton Films | false |
| 68 | Days of Darkness | - | - | - | $24,658 | 26 | $380,203 | Apr 11 | Golem Distribución | false |
| 69 | Night Watch | - | - | - | $21,760 | 5 | $73,925 | Mar 3 | Sagrera TV | false |
| 70 | The Princess of Nebraska | - | - | - | $21,621 | 6 | $32,576 | Jun 20 | Karma Films | false |
| 71 | It's All Gone Pete Tong 2008 Re-release | - | - | - | $21,434 | 15 | $43,177 | Jun 20 | Laurenfilm | false |
| 72 | Enloquecidas | - | - | - | $20,853 | 10 | $200,134 | Apr 11 | Premium Film | false |
| 73 | Shattered | - | - | - | $20,775 | 107 | $482,919 | Apr 30 | Manga Entertainment | false |
| 74 | The Duchess of Langeais | - | - | - | $20,521 | 10 | $188,572 | Apr 30 | Baditri | false |
| 75 | Honeydripper | - | - | - | $20,090 | 7 | $85,165 | May 16 | Golem Distribución | false |
| 76 | Todos estamos invitados | - | - | - | $19,457 | 111 | $1,251,557 | Apr 11 | Alta Films | false |
| 77 | Franklin and the Turtle Lake Treasure | - | - | - | $18,168 | 106 | $766,086 | Feb 22 | Wanda Visión S.A. | false |
| 78 | Rendition | - | - | - | $17,248 | 222 | $1,350,950 | Apr 18 | TriPictures | false |
| 79 | Before the Fall | - | - | - | $17,135 | 128 | $328,946 | Apr 25 | Universal Pictures International (UPI) | false |
| 80 | Cashback | - | - | - | $16,690 | 26 | $206,570 | Apr 11 | Laurenfilm | false |
| 81 | Mirror Maze | - | - | - | $15,967 | 124 | $119,572 | Apr 25 | Walt Disney Pictures | false |
| 82 | Dan in Real Life | - | - | - | $14,796 | 191 | $2,706,563 | Mar 19 | Universal Pictures International (UPI) | false |
| 83 | Wonderful Town | - | - | - | $12,700 | 2 | $25,407 | Jun 20 | - | false |
| 84 | Strange Wilderness | - | - | - | $9,615 | 8 | $9,615 | Jun 13 | Universal Pictures International (UPI) | false |
| 85 | Things We Lost in the Fire | - | - | - | $9,342 | 68 | $322,292 | Apr 25 | Universal Pictures International (UPI) | false |
| 86 | Buddha Collapsed Out of Shame | - | - | - | $9,254 | 19 | $489,438 | Feb 29 | Wanda Visión S.A. | false |
| 87 | A Tram in SP | - | - | - | $8,463 | 52 | $271,475 | Apr 30 | Aurum Films | false |
| 88 | The Kite Runner | - | - | - | $8,050 | 135 | $1,870,588 | Mar 7 | Universal Pictures International (UPI) | false |
| 89 | How She Move | - | - | - | $7,754 | 8 | $7,754 | Jun 13 | Universal Pictures International (UPI) | false |
| 90 | Definitely, Maybe | - | - | - | $6,738 | 45 | $306,791 | May 9 | Universal Pictures International (UPI) | false |
| 91 | Fay Grim | - | - | - | $6,622 | 3 | $11,851 | May 30 | Avalon | false |
| 92 | The Aerial | - | - | - | $6,062 | 4 | $45,123 | May 9 | Sherlock Films | false |
| 93 | The Pope's Toilet | - | - | - | $6,062 | 15 | $94,542 | Apr 25 | Golem Distribución | false |
| 94 | Abrígate | - | - | - | $5,214 | 20 | $87,863 | May 23 | Walt Disney Pictures | false |
| 95 | La crisis carnívora | - | - | - | $4,857 | 84 | $94,858 | May 16 | Aurum Films | false |
| 96 | Closing the Ring | - | - | - | $2,363 | 24 | $269,893 | Mar 14 | Manga Entertainment | false |
| 97 | Broken Sky | - | - | - | $2,123 | 2 | $25,811 | May 16 | Karma Films | false |
| 98 | Ellos robaron la picha de Hitler | - | - | - | $2,120 | 2 | $2,120 | Jun 6 | Manga Entertainment | false |
| 99 | Into the Wild | - | - | - | $1,625 | 81 | $780,998 | Jan 25 | Universal Pictures International (UPI) | false |
| 100 | Andalucia | - | - | - | $1,439 | 2 | $1,439 | Jun 13 | Baditri | false |
| 101 | One Missed Call | - | - | - | $871 | 165 | $2,119,000 | Mar 19 | Warner Bros. | false |
