| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Happening | - | - | - | $643,871 | 45 | $909,267 | Jun 12 | 20th Century Fox International | false |
| 2 | The Chronicles of Narnia: Prince Caspian | - | - | - | $602,822 | 71 | $2,215,829 | May 15 | Walt Disney Pictures | false |
| 3 | WALL·E | - | - | - | $545,035 | 58 | $3,312,890 | Jun 26 | Walt Disney Pictures | false |
| 4 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $463,772 | 70 | $1,255,634 | May 22 | United International Pictures | false |
| 5 | Get Smart | - | - | - | $366,071 | 49 | $610,269 | Jun 19 | Warner Bros. | false |
| 6 | The Incredible Hulk | - | - | - | $312,808 | 56 | $340,611 | Jun 12 | United International Pictures | false |
| 7 | What Happens in Vegas | - | - | - | $256,190 | 25 | $375,070 | May 29 | 20th Century Fox International | false |
| 8 | 21 | - | - | - | $175,217 | 20 | $210,253 | Jun 5 | Sony Pictures Releasing | false |
| 9 | The Orphanage | - | - | - | $136,659 | 16 | $733,144 | May 1 | CDI Films | false |
| 10 | Away from Her | - | - | - | $103,201 | 8 | $107,796 | Jun 5 | Bazuca Films | false |
| 11 | Two Days in Paris | - | - | - | $63,619 | 6 | $94,113 | May 29 | Impacto Cine | false |
| 12 | Speed Racer | - | - | - | $61,541 | 40 | $664,921 | May 8 | Warner Bros. | false |
| 13 | The Ugly Duckling and Me! | - | - | - | $58,267 | 10 | $59,025 | Jun 5 | Andes Films | false |
| 14 | An American Haunting | - | - | - | $48,040 | 18 | $410,016 | Apr 17 | Bazuca Films | false |
| 15 | Iron Man | - | - | - | $39,969 | 41 | $1,383,728 | Apr 30 | United International Pictures | false |
| 16 | P2 | - | - | - | $22,377 | 12 | $41,312 | May 29 | Bazuca Films | false |
| 17 | Definitely, Maybe | - | - | - | $22,102 | 15 | $32,040 | Jun 26 | United International Pictures | false |
| 18 | Shutter | - | - | - | $19,069 | 21 | $209,914 | Apr 17 | 20th Century Fox International | false |
| 19 | Street Kings | - | - | - | $18,876 | 8 | $35,163 | Jun 26 | 20th Century Fox International | false |
| 20 | The Hunting Party | - | - | - | $18,793 | 15 | $19,099 | Jun 19 | Bazuca Films | false |
| 21 | The Nanny Diaries | - | - | - | $13,076 | 8 | $13,076 | Jun 19 | Transeuropa | false |
| 22 | Charlie Wilson's War | - | - | - | $12,002 | 21 | $191,422 | May 8 | United International Pictures | false |
| 23 | Elite Squad | - | - | - | $7,204 | 6 | $12,857 | Jun 26 | United International Pictures | false |
| 24 | Shine a Light | - | - | - | $6,850 | 10 | $12,010 | Jun 26 | - | false |
| 25 | About Crying | - | - | - | $5,327 | 1 | $11,335 | May 29 | Quality Films | false |
| 26 | Salvador | - | - | - | $3,972 | 12 | $3,972 | Jun 19 | Andes Films | false |
| 27 | 1973 revoluciones por minuto | - | - | - | $3,887 | 2 | $3,887 | Jun 19 | Andes Films | false |
| 28 | U2 3D | - | - | - | $2,881 | 1 | $46,583 | May 1 | - | false |
| 29 | Meet the Spartans | - | - | - | $2,644 | 24 | $153,041 | Apr 24 | 20th Century Fox International | false |
| 30 | The Page Turner | - | - | - | $1,528 | 2 | $24,630 | May 9 | Four Films | false |
| 31 | Elizabeth: The Golden Age | - | - | - | $1,009 | 4 | $48,413 | May 15 | United International Pictures | false |
| 32 | Lassie | - | - | - | $577 | 13 | $40,569 | May 1 | Bazuca Films | false |
| 33 | Whisper | - | - | - | $501 | 12 | $21,877 | Apr 24 | Transeuropa | false |
