| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Chronicles of Narnia: Prince Caspian | - | - | - | $2,857,485 | 189 | $3,702,166 | Jun 12 | Walt Disney Pictures | false |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $1,200,923 | 141 | $3,007,401 | May 22 | United International Pictures | false |
| 3 | Sex and the City | - | - | - | $1,115,781 | 72 | $1,694,714 | Jun 12 | Distribution Company | false |
| 4 | The Happening | - | - | - | $723,083 | 50 | $1,341,309 | Jun 19 | 20th Century Fox International | false |
| 5 | Get Smart | - | - | - | $722,322 | 107 | $2,252,024 | Jun 26 | Warner Bros. | false |
| 6 | The Incredible Hulk | - | - | - | $688,494 | 80 | $935,727 | Jun 19 | United International Pictures | false |
| 7 | Cassandra's Dream | - | - | - | $450,621 | 30 | $583,973 | Jun 5 | Alfa Films | false |
| 8 | The Mist | - | - | - | $362,457 | 31 | $428,010 | Jun 5 | Distribution Company | false |
| 9 | Made of Honor | - | - | - | $330,556 | 30 | $355,379 | Jun 5 | Sony Pictures Releasing | false |
| 10 | What Happens in Vegas | - | - | - | $287,816 | 30 | $790,709 | May 15 | 20th Century Fox International | false |
| 11 | Death at a Funeral | - | - | - | $247,162 | 33 | $2,153,078 | Mar 6 | Compañía General de la Imagen (CGI) | false |
| 12 | Speed Racer | - | - | - | $203,663 | 94 | $2,044,203 | May 8 | Warner Bros. | false |
| 13 | 88 Minutes | - | - | - | $200,881 | 31 | $396,117 | May 29 | Distribution Company | false |
| 14 | The Oxford Murders | - | - | - | $143,972 | 23 | $589,788 | May 8 | Pachamama Cine | false |
| 15 | A Secret | - | - | - | $103,868 | 13 | $207,016 | Jun 19 | Alfa Films | false |
| 16 | The Counterfeiters | - | - | - | $82,724 | 22 | $398,205 | May 15 | Alfa Films | false |
| 17 | Leonera | - | - | - | $77,355 | 30 | $486,380 | May 29 | Walt Disney Pictures | false |
| 18 | Iron Man | - | - | - | $77,352 | 82 | $1,606,400 | Apr 30 | United International Pictures | false |
| 19 | My Blueberry Nights | - | - | - | $65,113 | 19 | $226,167 | Jun 26 | Distribution Company | false |
| 20 | Aniceto | - | - | - | $61,783 | 32 | $134,481 | Jun 12 | Primer Plano Film Group | false |
| 21 | The Nest | - | - | - | $59,921 | 39 | $1,008,755 | Apr 24 | Distribution Company | false |
| 22 | Awake | - | - | - | $59,270 | 31 | $274,878 | May 15 | Distribution Company | false |
| 23 | Heartbeat Detector | - | - | - | $58,413 | 3 | $87,635 | Jun 5 | Zeta Films | false |
| 24 | Shutter | - | - | - | $46,145 | 33 | $506,762 | Apr 17 | 20th Century Fox International | false |
| 25 | The Unknown Woman | - | - | - | $39,037 | 19 | $182,369 | May 22 | Impacto Cine | false |
| 26 | Conversations with My Gardener | - | - | - | $38,518 | 14 | $221,688 | Apr 24 | Alfa Films | false |
| 27 | In the Valley of Elah | - | - | - | $34,129 | 15 | $337,252 | Apr 3 | Alfa Films | false |
| 28 | 21 | - | - | - | $33,275 | 57 | $737,889 | Apr 17 | Sony Pictures Releasing | false |
| 29 | Jumper | - | - | - | $27,436 | 62 | $641,845 | Apr 3 | 20th Century Fox International | false |
| 30 | Mrs Palfrey at the Claremont 2008 Re-release | - | - | - | $25,146 | 4 | $88,099 | May 15 | Primer Plano Film Group | false |
| 31 | Café de los maestros | - | - | - | $22,356 | 8 | $94,126 | Jun 26 | Alfa Films | false |
| 32 | 10,000 BC | - | - | - | $21,715 | 76 | $2,262,479 | Mar 6 | Warner Bros. | false |
| 33 | Lamb of God | - | - | - | $21,086 | 13 | $144,627 | May 8 | Alfa Films | false |
| 34 | Love by Accident | - | - | - | $16,737 | 18 | $39,247 | May 29 | Primer Plano Film Group | false |
| 35 | Untraceable | - | - | - | $13,884 | 29 | $203,169 | Apr 24 | Sony Pictures Releasing | false |
| 36 | Two Days in Paris | - | - | - | $12,643 | 19 | $373,612 | Mar 27 | Impacto Cine | false |
| 37 | Odette Toulemonde | - | - | - | $12,383 | 8 | $30,472 | May 29 | Notro Films | false |
| 38 | Street Kings | - | - | - | $11,509 | 37 | $249,414 | Apr 24 | 20th Century Fox International | false |
| 39 | The Orphanage | - | - | - | $11,244 | 35 | $752,899 | Mar 13 | CDI Films | false |
| 40 | The Spiderwick Chronicles | - | - | - | $10,667 | 54 | $694,010 | Mar 20 | United International Pictures | false |
| 41 | I'm Not There | - | - | - | $9,013 | 5 | $11,127 | Jun 19 | Pachamama Cine | false |
| 42 | Caramel | - | - | - | $8,521 | 13 | $232,704 | Mar 27 | Alfa Films | false |
| 43 | Underdog | - | - | - | $8,417 | 46 | $886,546 | Oct 4 | Walt Disney Pictures | false |
| 44 | La león | - | - | - | $7,968 | 4 | $8,333 | Jun 12 | 791 Cine | false |
| 45 | U2 3D | - | - | - | $7,581 | 1 | $140,453 | Mar 27 | IMAX | false |
| 46 | P.S. I Love You | - | - | - | $6,240 | 29 | $463,222 | Feb 28 | Alfa Films | false |
| 47 | The Savages | - | - | - | $6,216 | 16 | $120,051 | May 1 | 20th Century Fox International | false |
| 48 | Atonement | - | - | - | $5,604 | 43 | $533,834 | Feb 7 | United International Pictures | false |
| 49 | Juno | - | - | - | $5,118 | 41 | $474,042 | Feb 14 | Alfa Films | false |
| 50 | Evening | - | - | - | $4,418 | 21 | $193,691 | Apr 10 | Impacto Cine | false |
| 51 | Yo soy sola | - | - | - | $4,349 | 10 | $38,523 | May 15 | Alfa Films | false |
| 52 | We Own the Night | - | - | - | $3,807 | 17 | $87,020 | May 1 | CDI Films | false |
| 53 | No ser Dios y cuidarlos | - | - | - | $3,523 | 3 | $3,523 | Jun 5 | Primer Plano Film Group | false |
| 54 | Mr. Woodcock | - | - | - | $2,633 | 23 | $106,745 | Apr 3 | Distribution Company | false |
| 55 | King of California | - | - | - | $2,433 | 25 | $72,016 | Apr 10 | Distribution Company | false |
| 56 | The Game Plan | - | - | - | $2,147 | 58 | $1,519,256 | Feb 14 | Walt Disney Pictures | false |
| 57 | No Country for Old Men | - | - | - | $1,581 | 52 | $1,002,429 | Mar 6 | Walt Disney Pictures | false |
| 58 | Lust, Caution | - | - | - | $1,221 | 18 | $60,943 | May 1 | Distribution Company | false |
| 59 | The Ugly Duckling and Me! | - | - | - | $1,076 | 54 | $79,897 | Mar 20 | - | false |
| 60 | S.O.S. Ex | - | - | - | $757 | 3 | $8,731 | May 15 | - | false |
| 61 | The Hunting Party | - | - | - | $601 | 34 | $317,644 | Mar 20 | Distribution Company | false |
| 62 | Twice Upon a Time | - | - | - | $406 | 18 | $110,611 | Apr 17 | Pachamama Cine | false |
| 63 | Horton Hears a Who! | - | - | - | $401 | 105 | $1,253,165 | Mar 13 | 20th Century Fox International | false |
| 64 | Enchanted | - | - | - | $340 | 108 | $2,862,455 | Jan 3 | Walt Disney Pictures | false |
| 65 | Alvin and the Chipmunks | - | - | - | $264 | 69 | $833,808 | Jan 3 | 20th Century Fox International | false |
| 66 | The Water Horse | - | - | - | $238 | 38 | $590,991 | Feb 7 | Sony Pictures Releasing | false |
| 67 | Gone Baby Gone | - | - | - | $169 | 21 | $436,926 | Nov 22 | Walt Disney Pictures | false |
| 68 | There Will Be Blood | - | - | - | $118 | 36 | $520,135 | Feb 21 | Walt Disney Pictures | false |
| 69 | Rain | - | - | - | $116 | 31 | $164,286 | Mar 20 | Walt Disney Pictures | false |
| 70 | Shine a Light | - | - | - | $72 | 33 | $99,576 | Apr 10 | Distribution Company | false |
| 71 | Silk | - | - | - | $69 | 5 | $11,485 | May 8 | Distribution Company | false |
