| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: At World's End | - | - | - | $1,135,993 | 101 | $2,125,665 | May 25 | Buena Vista International | false |
| 2 | Ocean's Thirteen | - | - | - | $824,397 | 73 | $1,474,708 | Jun 15 | Warner Bros. | false |
| 3 | Fantastic Four: Rise of the Silver Surfer | - | - | - | $652,966 | 73 | $1,520,782 | Jun 22 | 20th Century Fox International | false |
| 4 | Next | - | - | - | $549,853 | 60 | $746,809 | Jun 1 | NuMetro Distribution | false |
| 5 | Spider-Man 3 | - | - | - | $526,214 | 129 | $2,545,163 | May 4 | Sony Pictures Releasing | false |
| 6 | Fracture | - | - | - | $197,765 | 47 | $603,937 | May 11 | NuMetro Distribution | false |
| 7 | Stomp the Yard | - | - | - | $170,768 | 22 | $449,476 | Jun 15 | Sony Pictures Releasing | false |
| 8 | Premonition | - | - | - | $134,730 | 37 | $401,884 | Jun 22 | NuMetro Distribution | false |
| 9 | Employee of the Month | - | - | - | $130,646 | 35 | $351,959 | May 11 | Ster-Kinekor Pictures | false |
| 10 | Alpha Dog | - | - | - | $113,281 | 30 | $113,281 | Jun 8 | NuMetro Distribution | false |
| 11 | Blades of Glory | - | - | - | $112,310 | 35 | $327,845 | May 11 | United International Pictures | false |
| 12 | I Think I Love My Wife | - | - | - | $106,011 | 12 | $106,011 | Jun 1 | 20th Century Fox International | false |
| 13 | The Reaping | - | - | - | $102,699 | 25 | $102,699 | Jun 8 | Warner Bros. | false |
| 14 | Akeelah and the Bee | - | - | - | $80,885 | 20 | $80,885 | Jun 1 | Ster-Kinekor Pictures | false |
| 15 | Perfect Stranger | - | - | - | $67,273 | 30 | $651,226 | Apr 20 | Sony Pictures Releasing | false |
| 16 | As It Is in Heaven | - | - | - | $37,895 | 7 | $748,386 | Apr 27 | Ster-Kinekor Pictures | false |
| 17 | The Reef | - | - | - | $35,998 | 36 | $293,930 | Apr 20 | NuMetro Distribution | false |
| 18 | The Number 23 | - | - | - | $28,593 | 25 | $114,389 | May 18 | NuMetro Distribution | false |
| 19 | Reno 911!: Miami | - | - | - | $22,333 | 10 | $26,644 | Jun 8 | United International Pictures | false |
| 20 | Freedom Writers | - | - | - | $22,082 | 33 | $88,578 | May 18 | United International Pictures | false |
| 21 | Shooter | - | - | - | $17,363 | 46 | $393,230 | Apr 27 | United International Pictures | false |
| 22 | Mr. Bean's Holiday | - | - | - | $17,355 | 79 | $2,258,928 | Mar 30 | United International Pictures | false |
| 23 | Firehouse Dog | - | - | - | $15,609 | 10 | $61,517 | Jun 15 | 20th Century Fox International | false |
| 24 | Perfume: The Story of a Murderer | - | - | - | $15,362 | 5 | $28,199 | May 25 | NuMetro Distribution | false |
| 25 | Goal II: Living the Dream | - | - | - | $13,200 | 10 | $13,200 | Jun 8 | Buena Vista International | false |
| 26 | Driving Lessons | - | - | - | $12,989 | 7 | $12,989 | Jun 1 | Ster-Kinekor Pictures | false |
| 27 | The Hills Have Eyes 2 | - | - | - | $10,882 | 27 | $131,114 | May 11 | 20th Century Fox International | false |
| 28 | Samoan Wedding | - | - | - | $9,748 | 15 | $9,478 | Jun 8 | Ster-Kinekor Pictures | false |
| 29 | The History Boys | - | - | - | $5,419 | 10 | $200,325 | Apr 13 | 20th Century Fox International | false |
| 30 | Hot Fuzz | - | - | - | $2,901 | 50 | $269,231 | Apr 20 | United International Pictures | false |
| 31 | Ghost Rider | - | - | - | $861 | 55 | $796,963 | Apr 6 | Sony Pictures Releasing | false |
