| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Fantastic Four: Rise of the Silver Surfer | - | - | - | $1,977,921 | 86 | $2,078,387 | Jun 14 | - | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $1,796,651 | 114 | $3,980,470 | May 24 | - | false |
| 3 | Transformers | - | - | - | $1,530,632 | 95 | $5,326,029 | Jun 28 | - | false |
| 4 | Shrek the Third | - | - | - | $1,396,685 | 55 | $1,385,017 | May 31 | - | false |
| 5 | Sivaji | - | - | - | $864,479 | 54 | $2,435,416 | Jun 14 | - | false |
| 6 | Ocean's Thirteen | - | - | - | $552,798 | 40 | $549,297 | Jun 7 | Warner Bros. | false |
| 7 | Waris Jari Hantu | - | - | - | $198,227 | 37 | $512,937 | May 31 | Golden Scene | false |
| 8 | Surf's Up | - | - | - | $192,090 | 27 | $243,285 | Jun 21 | - | false |
| 9 | Unnale Unnale | - | - | - | $146,386 | 9 | $250,905 | Apr 12 | - | false |
| 10 | Spider-Man 3 | - | - | - | $145,166 | 110 | $4,925,519 | May 1 | - | false |
| 11 | Alone | - | - | - | $122,555 | 25 | $263,526 | Jun 21 | - | false |
| 12 | Live Free or Die Hard | - | - | - | $116,074 | 79 | $1,524,691 | Jul 5 | - | false |
| 13 | 200 Pounds Beauty | - | - | - | $107,757 | 10 | $115,141 | Jun 7 | - | false |
| 14 | Eye in the Sky | - | - | - | $82,354 | 17 | $91,661 | Jun 21 | - | false |
| 15 | The Last Mimzy | - | - | - | $65,214 | 9 | $65,214 | May 31 | - | false |
| 16 | Bloody Reunion | - | - | - | $60,078 | 15 | $68,756 | Jun 7 | Sony Pictures Releasing | false |
| 17 | Hot Fuzz | - | - | - | $52,325 | 15 | $60,299 | Jun 21 | - | false |
| 18 | My Wife Is a Gangster 3 | - | - | - | $40,694 | 10 | $52,723 | Jun 21 | - | false |
| 19 | Blades of Glory | - | - | - | $40,524 | 42 | $252,318 | May 17 | - | false |
| 20 | Ghost Train | - | - | - | $33,752 | 17 | $82,004 | Jun 14 | - | false |
| 21 | Priceless | - | - | - | $13,847 | 3 | $21,210 | May 24 | - | false |
| 22 | 28 Weeks Later | - | - | - | $13,168 | 30 | $356,430 | May 10 | - | false |
| 23 | Next | - | - | - | $10,894 | 39 | $479,813 | May 10 | - | false |
| 24 | The Namesake | - | - | - | $8,815 | 3 | $8,815 | May 31 | - | false |
| 25 | Pocong 2 | - | - | - | $6,452 | 7 | $45,365 | May 17 | - | false |
| 26 | Men in White | - | - | - | $4,989 | 9 | $117,365 | Jun 7 | - | false |
| 27 | Sumolah | - | - | - | $3,915 | 55 | $349,059 | May 10 | - | false |
| 28 | Snow Cake | - | - | - | $2,991 | 3 | $3,785 | Jun 21 | - | false |
| 29 | Sophie Scholl: The Final Days | - | - | - | $2,709 | 1 | $2,913 | Jun 7 | - | false |
| 30 | Ming Ming | - | - | - | $2,502 | 10 | $31,926 | May 17 | - | false |
| 31 | I Don't Want to Sleep Alone | - | - | - | $2,384 | 1 | $12,845 | May 17 | - | false |
| 32 | Ninaithu Ninaithu Parthen | - | - | - | $2,128 | 5 | $13,464 | May 17 | - | false |
| 33 | Naan Avanillai | - | - | - | $1,858 | 4 | $41,836 | Apr 19 | - | false |
| 34 | Wild Hogs | - | - | - | $1,071 | 39 | $674,561 | Apr 19 | - | false |
| 35 | The Messengers | - | - | - | $685 | 10 | $79,054 | Apr 19 | - | false |
| 36 | The Hills Have Eyes 2 | - | - | - | $654 | 30 | $409,932 | Apr 26 | - | false |
| 37 | Sunshine | - | - | - | $603 | 38 | $367,868 | Apr 12 | - | false |
| 38 | Catch and Release | - | - | - | $253 | 9 | $39,028 | Apr 5 | - | false |
| 39 | Parattai Engira Azhagu Sundaram | - | - | - | $53 | 5 | $57,078 | Apr 26 | - | false |
