| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Shrek the Third | - | - | - | $1,934,603 | 43 | $3,004,543 | Jun 14 | United International Pictures | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $1,542,752 | 100 | $2,772,756 | May 24 | Buena Vista International | false |
| 3 | Ratatouille | - | - | - | $382,754 | 58 | $2,230,163 | Jun 28 | Buena Vista International | false |
| 4 | Papelucho y el marciano | - | - | - | $341,337 | 33 | $969,819 | May 17 | Bazuca Films | false |
| 5 | Fantastic Four: Rise of the Silver Surfer | - | - | - | $241,951 | 40 | $773,574 | Jun 28 | 20th Century Fox International | false |
| 6 | Spider-Man 3 | - | - | - | $214,563 | 90 | $2,916,160 | May 3 | Sony Pictures Releasing | false |
| 7 | Perfume: The Story of a Murderer | - | - | - | $206,629 | 58 | $500,631 | Jun 21 | Bazuca Films | false |
| 8 | Zodiac | - | - | - | $168,581 | 12 | $184,495 | May 31 | Warner Bros. | false |
| 9 | Paris, Je T'aime | - | - | - | $77,632 | 6 | $136,256 | Jun 14 | - | false |
| 10 | Scoop | - | - | - | $69,367 | 7 | $192,110 | May 10 | CDI Films | false |
| 11 | Hostel: Part II | - | - | - | $65,003 | 14 | $96,773 | Jun 21 | Sony Pictures Releasing | false |
| 12 | The Wicker Man | - | - | - | $60,971 | 15 | $111,166 | Jun 7 | Bazuca Films | false |
| 13 | The Queen | - | - | - | $27,094 | 9 | $265,563 | Apr 26 | Bazuca Films | false |
| 14 | The Good Shepherd | - | - | - | $25,238 | 6 | $119,694 | Apr 26 | United International Pictures | false |
| 15 | The Reaping | - | - | - | $19,099 | 31 | $469,168 | Apr 5 | Warner Bros. | false |
| 16 | Tsotsi | - | - | - | $18,544 | 3 | $21,325 | Jun 21 | Bazuca Films | false |
| 17 | Crank | - | - | - | $14,671 | 11 | $43,036 | Jun 7 | Transeuropa | false |
| 18 | A Prairie Home Companion | - | - | - | $14,260 | 6 | $14,260 | May 31 | - | false |
| 19 | Hoodwinked! | - | - | - | $13,851 | 20 | $257,026 | Apr 26 | Transeuropa | false |
| 20 | Sunshine | - | - | - | $13,357 | 14 | $115,056 | Apr 26 | 20th Century Fox International | false |
| 21 | Pulse | - | - | - | $7,829 | 14 | $173,249 | Apr 19 | Bazuca Films | false |
| 22 | Apocalypto | - | - | - | $7,073 | 23 | $365,537 | Mar 8 | 20th Century Fox International | false |
| 23 | Hard Candy | - | - | - | $7,030 | 3 | $30,108 | May 17 | Bazuca Films | false |
| 24 | Shooter | - | - | - | $5,490 | 22 | $106,196 | Apr 12 | United International Pictures | false |
| 25 | Meet the Robinsons | - | - | - | $3,201 | 39 | $519,115 | Apr 5 | Buena Vista International | false |
| 26 | Epic Movie | - | - | - | $2,650 | 14 | $166,404 | Apr 19 | 20th Century Fox International | false |
| 27 | Happily N'Ever After | - | - | - | $2,244 | 15 | $144,606 | Apr 19 | Bazuca Films | false |
| 28 | TMNT | - | - | - | $1,862 | 26 | $234,670 | Apr 5 | Bazuca Films | false |
| 29 | Mr. Bean's Holiday | - | - | - | $1,398 | 25 | $309,265 | Apr 5 | United International Pictures | false |
| 30 | Man About Town | - | - | - | $1,054 | 7 | $19,885 | May 10 | Andes Films | false |
| 31 | Pathfinder | - | - | - | $657 | 18 | $122,882 | Apr 12 | 20th Century Fox International | false |
| 32 | Ghost Rider | - | - | - | $435 | 36 | $268,740 | Apr 5 | Sony Pictures Releasing | false |
| 33 | Music and Lyrics | - | - | - | $286 | 27 | $209,768 | Mar 15 | Warner Bros. | false |
