| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Da Vinci Code | - | - | - | $9,946,626 | 910 | $39,197,477 | May 19 | Sony Pictures Releasing | false |
| 2 | The Breed | - | - | - | $4,024,835 | 123 | $512,073 | Jun 2 | Medusa Distribuzione | false |
| 3 | Poseidon | - | - | - | $3,592,649 | 347 | $3,854,218 | Jun 1 | Warner Bros. | false |
| 4 | Volver | - | - | - | $3,572,151 | 309 | $8,641,208 | May 19 | Warner Bros. | false |
| 5 | X-Men: The Last Stand | - | - | - | $3,565,845 | 463 | $7,401,192 | May 26 | 20th Century Fox International | false |
| 6 | Hoodwinked | - | - | - | $1,624,159 | 168 | $1,768,995 | Jun 1 | 01 Distribution | false |
| 7 | The Omen | - | - | - | $1,438,165 | 352 | $2,128,019 | Jun 9 | 20th Century Fox International | false |
| 8 | A Prairie Home Companion | - | - | - | $1,324,190 | 142 | $1,686,150 | Jun 1 | Medusa Distribuzione | false |
| 9 | Date Movie | - | - | - | $769,852 | 221 | $1,883,254 | Jun 23 | 20th Century Fox International | false |
| 10 | The Sentinel | - | - | - | $512,019 | 211 | $1,148,607 | Jun 23 | 01 Distribution | false |
| 11 | The Lake House | - | - | - | $490,496 | 186 | $1,649,852 | Jun 23 | Warner Bros. | false |
| 12 | American Dreamz | - | - | - | $445,069 | 100 | $517,300 | Jun 9 | United International Pictures | false |
| 13 | One Last Dance 2006 Re-release | - | - | - | $389,356 | 219 | $1,041,160 | May 26 | Eagle Pictures | false |
| 14 | By the Pricking of My Thumbs | - | - | - | $375,361 | 92 | $390,939 | Jun 16 | Medusa Distribuzione | false |
| 15 | Ultraviolet | - | - | - | $370,932 | 180 | $421,645 | Jun 16 | Sony Pictures Releasing | false |
| 16 | Mortuary | - | - | - | $338,607 | 176 | $494,672 | Jun 23 | Eagle Pictures | false |
| 17 | The Valet | - | - | - | $329,375 | 186 | $86,983 | May 12 | Medusa Distribuzione | false |
| 18 | RV | - | - | - | $322,568 | 92 | $347,517 | Jun 1 | Sony Pictures Releasing | false |
| 19 | Half Light | - | - | - | $300,043 | 119 | $300,043 | Jun 16 | United International Pictures | false |
| 20 | L'estate del mio primo bacio | - | - | - | $244,548 | 43 | $259,575 | Jun 1 | 01 Distribution | false |
| 21 | Orchestra Seats | - | - | - | $186,447 | 61 | $431,631 | Jun 16 | DNC Entertainment | false |
| 22 | Libero (Along the Ridge) | - | - | - | $184,741 | 74 | $975,349 | May 5 | 01 Distribution | false |
| 23 | Heading South | - | - | - | $121,221 | 47 | $178,561 | Jun 16 | Mikado Film | false |
| 24 | Romance & Cigarettes | - | - | - | $111,530 | 114 | $1,455,348 | May 5 | Nexo | false |
| 25 | The Dark | - | - | - | $110,080 | 111 | $128,215 | Jun 23 | Mediafilm | false |
| 26 | Mission: Impossible III | - | - | - | $97,340 | 621 | $7,636,309 | May 5 | United International Pictures | false |
| 27 | Midsummer Dream | - | - | - | $89,976 | 110 | $149,675 | May 26 | Medusa Distribuzione | false |
| 28 | The Shaggy Dog | - | - | - | $61,268 | 39 | $61,268 | Jun 9 | Buena Vista International | false |
| 29 | The Moustache | - | - | - | $47,745 | 22 | $210,359 | Jun 23 | Nexo | false |
| 30 | Shadows in the Sun | - | - | - | $35,443 | 53 | $35,443 | Jun 9 | Istituto Luce | false |
| 31 | 4-4-2 - Il gioco più bello del mondo | - | - | - | $29,165 | 101 | $452,097 | May 19 | Medusa Distribuzione | false |
| 32 | Anthony, Warrior of God | - | - | - | $26,721 | 25 | $26,721 | Jun 9 | 01 Distribution | false |
| 33 | The Wedding Director | - | - | - | $26,482 | 209 | $2,468,448 | Apr 21 | 01 Distribution | false |
| 34 | 11:11 | - | - | - | $26,141 | 13 | $29,198 | Jun 1 | Moviemax | false |
| 35 | Ten Canoes | - | - | - | $17,809 | 13 | $19,680 | Jun 1 | Fandango | false |
| 36 | Hell | - | - | - | $16,628 | 30 | $85,101 | Jun 9 | 01 Distribution | false |
