| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Crocodile Dundee II | - | - | - | $55,810,273 | 2,837 | $109,306,210 | May 25 | Paramount Pictures | false |
| 2 | Big | - | - | - | $46,439,069 | 1,419 | $114,968,774 | Jun 3 | Twentieth Century Fox | false |
| 3 | Rambo III | - | - | - | $25,177,944 | 2,562 | $53,715,611 | May 25 | TriStar Pictures | false |
| 4 | Willow | - | - | - | $23,422,089 | 1,209 | $57,269,863 | May 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 5 | Big Business | - | - | - | $23,063,360 | 1,232 | $40,150,487 | Jun 10 | Walt Disney Studios Motion Pictures | false |
| 6 | Who Framed Roger Rabbit | - | - | - | $22,711,133 | 1,598 | $156,452,370 | Jun 24 | Walt Disney Studios Motion Pictures | false |
| 7 | Funny Farm | - | - | - | $21,448,006 | 1,557 | $25,537,221 | Jun 3 | Warner Bros. | false |
| 8 | Red Heat | - | - | - | $20,288,175 | 1,892 | $34,994,648 | Jun 17 | TriStar Pictures | false |
| 9 | The Great Outdoors | - | - | - | $18,835,288 | 1,430 | $41,455,230 | Jun 17 | Universal Pictures | false |
| 10 | Bull Durham | - | - | - | $16,532,013 | 1,297 | $50,888,729 | Jun 17 | Orion Pictures | false |
| 11 | The Presidio | - | - | - | $14,390,684 | 1,168 | $20,324,096 | Jun 10 | Paramount Pictures | false |
| 12 | Beetlejuice | - | - | - | $12,100,568 | 1,582 | $73,707,461 | Mar 30 | Warner Bros. | false |
| 13 | Poltergeist III | - | - | - | $11,167,786 | 1,471 | $14,114,488 | Jun 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 14 | Colors | - | - | - | $8,938,661 | 1,388 | $46,616,067 | Apr 15 | Orion Pictures | false |
| 15 | Moonstruck | - | - | - | $5,281,592 | 1,178 | $80,640,528 | Dec 18 | Metro-Goldwyn-Mayer (MGM) | false |
| 16 | Good Morning, Vietnam | - | - | - | $4,469,565 | 1,598 | $123,922,370 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 17 | Friday the 13th: The New Blood | - | - | - | $3,552,976 | 1,796 | $19,170,001 | May 13 | Paramount Pictures | false |
| 18 | Three Men and a Baby | - | - | - | $3,469,246 | 1,813 | $167,780,960 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 19 | White Mischief | - | - | - | $3,059,914 | 87 | $3,107,551 | Apr 22 | Columbia Pictures | false |
| 20 | Biloxi Blues | - | - | - | $2,655,411 | 1,330 | $43,184,798 | Mar 25 | Universal Pictures | false |
| 21 | The Manchurian Candidate 1988 Re-release | - | - | - | $2,643,053 | 49 | $2,757,256 | Feb 12 | Metro-Goldwyn-Mayer (MGM) | false |
| 22 | The Milagro Beanfield War | - | - | - | $2,594,086 | 437 | $13,825,794 | Mar 18 | Universal Pictures | false |
| 23 | The Last Emperor | - | - | - | $2,569,637 | 877 | $43,984,230 | Nov 20 | Columbia Pictures | false |
| 24 | The Moderns | - | - | - | $1,978,262 | 28 | $2,011,497 | Apr 15 | Alive Films | false |
| 25 | Lady in White | - | - | - | $1,347,110 | 107 | $1,705,139 | Apr 22 | New Century | false |
| 26 | The Decline of Western Civilization Part II: The Metal Years | - | - | - | $373,743 | 21 | $373,743 | Jun 3 | New Line Cinema | false |
| 27 | A Handful of Dust | - | - | - | $56,208 | 29 | $1,560,700 | Jun 24 | New Line Cinema | false |
| 28 | A World Apart | - | - | - | $35,835 | 42 | $2,326,860 | Jun 17 | Atlantic Releasing Corporation | false |
