| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Shrek Forever After | - | - | - | $3,646,095 | 77 | $4,111,292 | Jul 8 | Paramount Pictures International | false |
| 2 | The Twilight Saga: Eclipse | - | - | - | $2,100,504 | 67 | $2,325,279 | Jul 15 | - | false |
| 3 | Toy Story 3 | - | - | - | $1,052,396 | 75 | $3,753,051 | Jun 17 | Walt Disney Pictures | false |
| 4 | Despicable Me | - | - | - | $967,381 | 62 | $2,092,292 | Jul 28 | Universal Pictures International (UPI) | false |
| 5 | The Sorcerer's Apprentice | - | - | - | $827,718 | 43 | $1,290,696 | Jul 22 | Walt Disney Pictures | false |
| 6 | Knight and Day Original Release | - | - | - | $477,199 | 45 | $611,861 | Jul 22 | 20th Century Fox International | false |
| 7 | The Spy Next Door 2010 Re-release | - | - | - | $358,435 | 27 | $422,376 | Jul 1 | - | false |
| 8 | Inception | - | - | - | $302,755 | 52 | $1,020,885 | Jul 29 | Warner Bros. | false |
| 9 | The Back-up Plan | - | - | - | $158,238 | 29 | $369,996 | Jun 24 | Sony Pictures Releasing | false |
| 10 | The A-Team | - | - | - | $153,579 | 40 | $390,906 | Jun 24 | 20th Century Fox International | false |
| 11 | The Crazies | - | - | - | $123,747 | 28 | $270,361 | Jul 28 | - | false |
| 12 | Anamorph | - | - | - | $60,287 | 10 | $63,000 | Jul 8 | - | false |
| 13 | Daybreakers | - | - | - | $47,076 | 21 | $163,362 | Jun 24 | - | false |
| 14 | Green Zone 2010 Re-release | - | - | - | $37,514 | 10 | $113,241 | Jun 24 | Paramount Pictures International | false |
| 15 | Prince of Persia: The Sands of Time | - | - | - | $32,769 | 58 | $1,845,122 | May 27 | Walt Disney Pictures | false |
| 16 | The Echo | - | - | - | $31,648 | 18 | $105,781 | Jul 8 | - | false |
| 17 | Sex and the City 2 | - | - | - | $30,248 | 30 | $607,576 | Jun 3 | Warner Bros. | false |
| 18 | Marmaduke | - | - | - | $19,405 | 35 | $685,981 | Jun 3 | 20th Century Fox International | false |
| 19 | While She Was Out | - | - | - | $9,116 | 15 | $88,794 | May 27 | - | false |
| 20 | The Fourth Kind | - | - | - | $7,655 | 16 | $322,654 | May 20 | - | false |
| 21 | Dear John | - | - | - | $7,402 | 11 | $142,444 | Apr 22 | Sony Pictures Releasing | false |
| 22 | 100 Feet | - | - | - | $6,120 | 20 | $237,707 | Jun 10 | - | false |
| 23 | Robin Hood | - | - | - | $3,092 | 46 | $995,267 | May 13 | Universal Pictures International (UPI) | false |
| 24 | Crazy Heart | - | - | - | $2,584 | 5 | $59,776 | Jun 10 | 20th Century Fox International | false |
| 25 | Remember Me | - | - | - | $1,957 | 20 | $162,659 | May 13 | - | false |
| 26 | The Last Song | - | - | - | $1,114 | 13 | $117,319 | Jun 3 | Walt Disney Pictures | false |
| 27 | Date Night | - | - | - | $784 | 28 | $426,137 | May 13 | 20th Century Fox International | false |
| 28 | Carriers | - | - | - | $779 | 16 | $69,930 | Jun 10 | - | false |
| 29 | Illary | - | - | - | $21 | 10 | $10,631 | Jun 17 | - | false |
