| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Twilight Saga: Eclipse | - | - | - | $14,687,086 | 788 | $20,711,944 | Jun 30 | Eagle Pictures | false |
| 2 | Toy Story 3 | - | - | - | $12,596,578 | 678 | $18,855,881 | Jul 7 | Walt Disney Pictures | false |
| 3 | Solomon Kane | - | - | - | $1,659,040 | 203 | $2,622,017 | Jul 14 | Eagle Pictures | false |
| 4 | Predators | - | - | - | $1,457,925 | 247 | $2,051,488 | Jul 14 | 20th Century Fox International | false |
| 5 | The Box | - | - | - | $907,992 | 194 | $1,874,782 | Jul 21 | Lucky Red | false |
| 6 | The A-Team | - | - | - | $783,435 | 354 | $3,143,928 | Jun 18 | 20th Century Fox International | false |
| 7 | Loose Cannons | - | - | - | $499,948 | 427 | $10,994,715 | Mar 12 | 01 Distribution | false |
| 8 | Prince of Persia: The Sands of Time | - | - | - | $472,170 | 548 | $8,912,558 | May 19 | Walt Disney Pictures | false |
| 9 | The Secret in Their Eyes | - | - | - | $374,802 | 73 | $1,566,701 | Jun 4 | Lucky Red | false |
| 10 | The Losers | - | - | - | $365,507 | 141 | $684,997 | Jul 23 | Warner Bros. | false |
| 11 | Basilicata Coast to Coast | - | - | - | $336,887 | 196 | $4,588,816 | Apr 9 | Eagle Pictures | false |
| 12 | Cop Out | - | - | - | $313,376 | 180 | $612,421 | Jun 25 | Warner Bros. | false |
| 13 | The Marc Pease Experience | - | - | - | $285,702 | 150 | $368,331 | Jul 14 | - | false |
| 14 | The Soloist | - | - | - | $263,172 | 100 | $511,406 | Jul 23 | United International Pictures | false |
| 15 | Bright Star | - | - | - | $212,169 | 97 | $912,003 | Jun 11 | 01 Distribution | false |
| 16 | I Hate Valentine's Day | - | - | - | $203,450 | 161 | $982,592 | Jun 18 | Eagle Pictures | false |
| 17 | L'imbroglio nel lenzuolo | - | - | - | $201,661 | 51 | $492,068 | Jun 18 | 01 Distribution | false |
| 18 | Brotherhood | - | - | - | $161,916 | 27 | $163,801 | Jul 2 | Lucky Red | false |
| 19 | City Island | - | - | - | $149,738 | 51 | $234,113 | Jun 25 | Mikado Film | false |
| 20 | Nanny McPhee Returns | - | - | - | $138,900 | 198 | $1,774,751 | Jun 4 | United International Pictures | false |
| 21 | The Maid | - | - | - | $105,299 | 14 | $176,605 | Jun 25 | - | false |
| 22 | The Hole | - | - | - | $98,680 | 310 | $2,094,728 | Jun 11 | Medusa Distribuzione | false |
| 23 | La nostra vita | - | - | - | $90,443 | 269 | $4,400,186 | May 21 | 01 Distribution | false |
| 24 | The Concert | - | - | - | $83,575 | 139 | $4,825,505 | Feb 5 | BIM Distribuzione | false |
| 25 | Sex and the City 2 | - | - | - | $75,512 | 476 | $7,802,889 | May 28 | Warner Bros. | false |
| 26 | Butterfly zone - Il senso della farfalla | - | - | - | $70,836 | - | $70,836 | Jul 2 | - | false |
| 27 | Robin Hood | - | - | - | $66,570 | 667 | $14,676,791 | May 12 | United International Pictures | false |
| 28 | Pope Joan | - | - | - | $57,773 | 148 | $925,787 | Jun 4 | Medusa Distribuzione | false |
| 29 | The Ghost Writer | - | - | - | $56,552 | 352 | $4,811,454 | Apr 9 | 01 Distribution | false |
| 30 | Remembering the Children | - | - | - | $55,053 | 22 | $263,808 | Jun 11 | Teodora Film | false |
| 31 | About Elly | - | - | - | $51,020 | 23 | $161,220 | Jun 18 | - | false |
| 32 | She's Out of My League | - | - | - | $49,889 | 60 | $308,584 | Jun 18 | United International Pictures | false |
| 33 | Our Family Wedding | - | - | - | $43,005 | 20 | $43,005 | Jul 23 | 20th Century Fox International | false |
| 34 | Departures | - | - | - | $37,041 | 42 | $868,327 | Apr 9 | - | false |
| 35 | The Road | - | - | - | $35,979 | 151 | $1,630,241 | May 28 | - | false |
| 36 | Saw VI | - | - | - | $31,854 | 300 | $2,520,502 | Jun 1 | 01 Distribution | false |
| 37 | Where in the World Is Osama Bin Laden? 2010 Re-release | - | - | - | $24,131 | 12 | $24,131 | Jul 9 | Fandango | false |
| 38 | Tooth Fairy | - | - | - | $22,560 | 91 | $458,881 | Jun 11 | 20th Century Fox International | false |
| 39 | Fish Tank | - | - | - | $22,471 | 23 | $22,471 | Jul 23 | - | false |
| 40 | The Time That Remains | - | - | - | $18,790 | 29 | $195,172 | Jun 4 | BIM Distribuzione | false |
| 41 | Avatar | - | - | - | $11,457 | 856 | $93,746,295 | Jan 15 | 20th Century Fox International | false |
| 42 | The Boys Are Back | - | - | - | $8,114 | 5 | $18,536 | Jun 25 | Walt Disney Pictures | false |
| 43 | Up in the Air | - | - | - | $6,519 | 339 | $7,439,717 | Jan 22 | United International Pictures | false |
| 44 | Una canzone per te | - | - | - | $6,514 | 205 | $413,920 | May 28 | United International Pictures | false |
| 45 | Post Grad | - | - | - | $6,064 | 10 | $6,064 | Jul 9 | 20th Century Fox International | false |
| 46 | Agora | - | - | - | $5,443 | 7 | $2,965,896 | Apr 23 | Mikado Film | false |
| 47 | The Final Destination | - | - | - | $5,424 | 338 | $4,590,236 | May 21 | Warner Bros. | false |
| 48 | Twilight | - | - | - | $5,337 | 551 | $14,410,854 | Nov 21 | Eagle Pictures | false |
| 49 | The First Beautiful Thing | - | - | - | $4,738 | 350 | $9,115,665 | Jan 15 | Medusa Distribuzione | false |
| 50 | The Twilight Saga: New Moon | - | - | - | $4,488 | 699 | $20,609,171 | Nov 18 | Eagle Pictures | false |
| 51 | Shutter Island | - | - | - | $4,379 | 433 | $9,434,156 | Mar 5 | Medusa Distribuzione | false |
| 52 | The Book of Masters | - | - | - | $3,804 | 15 | $74,225 | Jul 23 | Walt Disney Pictures | false |
| 53 | Draquila - L'Italia che trema | - | - | - | $3,781 | 28 | $2,124,529 | May 7 | BIM Distribuzione | false |
| 54 | Life During Wartime | - | - | - | $2,638 | 10 | $209,587 | Apr 16 | - | false |
| 55 | The Back-up Plan | - | - | - | $1,159 | 233 | $1,926,942 | May 14 | Sony Pictures Releasing | false |
| 56 | The Last Station 2010 Re-release | - | - | - | $754 | 30 | $124,692 | May 28 | Sony Pictures Releasing | false |
