| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Twilight Saga: Eclipse | - | - | - | $20,219,472 | 719 | $25,050,394 | Jun 30 | Aurum Films | false |
| 2 | Shrek Forever After | - | - | - | $16,179,315 | 761 | $21,928,719 | Jul 8 | Paramount Pictures International | false |
| 3 | Toy Story 3 | - | - | - | $9,254,930 | 719 | $33,154,762 | Jul 21 | Walt Disney Pictures | false |
| 4 | Knight and Day 2010 Re-release | - | - | - | $5,579,958 | 508 | $7,558,123 | Jul 15 | 20th Century Fox International | false |
| 5 | A Nightmare on Elm Street | - | - | - | $2,378,277 | 286 | $4,220,981 | Jul 23 | Warner Bros. | false |
| 6 | Prince of Persia: The Sands of Time | - | - | - | $1,921,055 | 603 | $13,327,923 | May 21 | Walt Disney Pictures | false |
| 7 | Marmaduke | - | - | - | $1,477,360 | 325 | $3,898,249 | Jun 18 | 20th Century Fox International | false |
| 8 | Robin Hood | - | - | - | $1,349,789 | 540 | $13,683,489 | May 13 | United International Pictures | false |
| 9 | Dorian Gray | - | - | - | $1,120,281 | 239 | $3,560,230 | Jun 11 | Aurum Films | false |
| 10 | Mother and Child | - | - | - | $1,040,544 | 91 | $1,636,486 | Jul 2 | - | false |
| 11 | The Blind Side | - | - | - | $1,022,430 | 223 | $2,529,601 | Jun 18 | Warner Bros. | false |
| 12 | Una hora más en Canarias | - | - | - | $898,271 | 274 | $1,059,788 | Jul 16 | Manga Entertainment | false |
| 13 | Sex and the City 2 | - | - | - | $795,924 | 347 | $5,814,149 | Jun 4 | Warner Bros. | false |
| 14 | How to Train Your Dragon | - | - | - | $641,315 | 577 | $12,458,930 | Mar 26 | Paramount Pictures International | false |
| 15 | To Hell with the Ugly | - | - | - | $640,785 | 296 | $9,246,548 | Apr 23 | Warner Bros. | false |
| 16 | Shutter Island | - | - | - | $565,083 | 406 | $11,402,431 | Feb 19 | Manga Entertainment | false |
| 17 | Furry Vengeance | - | - | - | $503,808 | 238 | $886,748 | Jun 25 | Aurum Films | false |
| 18 | Law Abiding Citizen | - | - | - | $485,860 | 301 | $4,678,297 | May 7 | Warner Bros. | false |
| 19 | The Diary of Carlota | - | - | - | $437,763 | 215 | $619,459 | Jul 23 | Aurum Films | false |
| 20 | The Ghost Writer | - | - | - | $427,725 | 289 | $7,125,447 | Mar 26 | Aurum Films | false |
| 21 | The Secret in Their Eyes | - | - | - | $410,480 | 18 | $8,220,014 | Sep 25 | Alta Films | false |
| 22 | Iron Man 2 | - | - | - | $394,547 | 547 | $7,601,695 | Apr 30 | Paramount Pictures International | false |
| 23 | The Private Lives of Pippa Lee | - | - | - | $312,302 | 103 | $556,691 | Jun 25 | TriPictures | false |
| 24 | La última cima | - | - | - | $280,149 | 72 | $968,401 | Jun 4 | - | false |
| 25 | London River 2010 Re-release | - | - | - | $260,335 | 46 | $412,385 | Jul 16 | Vértigo Films | false |
| 26 | Scar | - | - | - | $240,724 | 224 | $648,382 | Jun 25 | DeAPlaneta | false |
| 27 | Life Begins Today | - | - | - | $231,940 | 59 | $396,820 | Jun 25 | Filmax | false |
| 28 | Gainsbourg: A Heroic Life | - | - | - | $192,480 | 33 | $253,353 | Jul 9 | Avalon | false |
| 29 | Two Lovers | - | - | - | $168,223 | 125 | $1,768,721 | May 14 | DeAPlaneta | false |
| 30 | Trésor | - | - | - | $166,155 | 52 | $178,777 | Jul 9 | - | false |
| 31 | The Other Man | - | - | - | $163,319 | 112 | $843,394 | Jun 11 | DeAPlaneta | false |
| 32 | Nothing Personal | - | - | - | $157,139 | 17 | $263,176 | Jul 9 | Karma Films | false |
| 33 | Villa Amalia 2009 Re-release | - | - | - | $147,801 | 30 | $402,622 | Jun 18 | Karma Films | false |
| 34 | Leap Year | - | - | - | $147,287 | 62 | $305,205 | Jun 25 | United International Pictures | false |
| 35 | Cirque du Freak: The Vampire's Assistant | - | - | - | $122,012 | 29 | $129,463 | Jul 16 | United International Pictures | false |
| 36 | Mr. Nobody | - | - | - | $118,801 | 41 | $322,056 | Jul 23 | Wanda Visión S.A. | false |
| 37 | The Last Song | - | - | - | $117,860 | 317 | $1,997,548 | Jun 4 | Walt Disney Pictures | false |
| 38 | The White Ribbon | - | - | - | $117,783 | 45 | $2,226,344 | Jan 15 | Golem Distribución | false |
| 39 | The Secret of Moonacre | - | - | - | $116,935 | 60 | $117,181 | Jul 2 | - | false |
| 40 | Sunshine Cleaning | - | - | - | $114,023 | 36 | $270,421 | Jul 23 | - | false |
| 41 | Garfield's Pet Force | - | - | - | $113,708 | 213 | $1,232,775 | Jun 11 | - | false |
| 42 | Kick-Ass | - | - | - | $106,786 | 271 | $1,257,505 | Jun 4 | United International Pictures | false |
| 43 | Legion | - | - | - | $104,018 | 297 | $3,213,507 | May 28 | Sony Pictures Releasing | false |
| 44 | The Last Station 2010 Re-release | - | - | - | $100,994 | 31 | $450,391 | Jun 11 | Sony Pictures Releasing | false |
| 45 | Oceans | - | - | - | $96,072 | 123 | $1,638,607 | Apr 23 | Notro Films | false |
| 46 | I Am Love | - | - | - | $93,117 | 28 | $586,094 | May 21 | Alta Films | false |
| 47 | Scheherazade, Tell Me a Story | - | - | - | $83,243 | 6 | $172,975 | Jul 2 | Golem Distribución | false |
| 48 | Everyone Else | - | - | - | $77,947 | 30 | $155,014 | Jun 25 | Karma Films | false |
| 49 | Brother and Sister | - | - | - | $72,746 | 35 | $219,010 | Jun 18 | Alta Films | false |
| 50 | Death at a Funeral | - | - | - | $69,358 | 30 | $153,050 | Jun 25 | Sony Pictures Releasing | false |
| 51 | Soul Kitchen | - | - | - | $69,285 | 22 | $788,001 | Mar 31 | Golem Distribución | false |
| 52 | Magic Journey to Africa | - | - | - | $67,120 | 181 | $1,070,844 | May 7 | Filmax | false |
| 53 | Mammoth | - | - | - | $60,920 | 29 | $182,455 | Jun 4 | Golem Distribución | false |
| 54 | Alice in Wonderland | - | - | - | $59,947 | 646 | $28,769,165 | Apr 16 | Walt Disney Pictures | false |
| 55 | Vincere | - | - | - | $54,335 | 26 | $239,002 | Jun 11 | - | false |
| 56 | The Girl on the Train | - | - | - | $47,992 | 7 | $97,117 | Jun 25 | Vértigo Films | false |
| 57 | Our Family Wedding | - | - | - | $46,786 | 30 | $46,786 | Jul 2 | 20th Century Fox International | false |
| 58 | La venganza de Ira Vamp | - | - | - | $40,787 | 255 | $418,467 | Jun 18 | Sony Pictures Releasing | false |
| 59 | Pièce montée | - | - | - | $36,823 | 82 | $482,037 | May 21 | - | false |
| 60 | Room in Rome | - | - | - | $36,822 | 126 | $687,413 | May 7 | Paramount Pictures International | false |
| 61 | For 80 Days | - | - | - | $35,555 | 14 | $115,251 | May 21 | Barton Films | false |
| 62 | Air Doll | - | - | - | $34,839 | 18 | $93,106 | Jun 18 | Golem Distribución | false |
| 63 | God's Forgotten Town | - | - | - | $33,954 | 21 | $35,192 | Jul 9 | - | false |
| 64 | A Prophet | - | - | - | $32,668 | 58 | $567,672 | Feb 26 | Alta Films | false |
| 65 | Maria and I | - | - | - | $29,791 | 14 | $46,394 | Jul 16 | - | false |
| 66 | Campamento Flipy | - | - | - | $26,186 | 180 | $531,355 | Jun 11 | Walt Disney Pictures | false |
| 67 | Station of the Forgotten | - | - | - | $25,788 | 39 | $68,570 | Jun 4 | - | false |
| 68 | City of Life and Death | - | - | - | $23,192 | 45 | $435,634 | Apr 9 | Karma Films | false |
| 69 | The Crazies | - | - | - | $22,678 | 203 | $827,739 | May 28 | - | false |
| 70 | She, a Chinese | - | - | - | $22,158 | 5 | $38,900 | Jul 16 | Golem Distribución | false |
| 71 | Fashion Victim | - | - | - | $22,154 | 11 | $221,021 | May 14 | Alta Films | false |
| 72 | About Elly | - | - | - | $22,075 | 6 | $142,370 | May 21 | Golem Distribución | false |
| 73 | I, Don Giovanni | - | - | - | $18,267 | 9 | $28,904 | Jun 25 | - | false |
| 74 | The Good Heart | - | - | - | $16,897 | 29 | $138,373 | Jun 4 | Alta Films | false |
| 75 | The God of Wood | - | - | - | $14,864 | 6 | $22,780 | Jul 16 | Sagrera TV | false |
| 76 | StreetDance 2 | - | - | - | $13,680 | 210 | $1,607,853 | May 28 | Aurum Films | false |
| 77 | No One Knows About Persian Cats | - | - | - | $7,311 | 28 | $130,513 | Apr 16 | Alta Films | false |
| 78 | The Island Inside | - | - | - | $6,440 | 43 | $317,155 | Apr 9 | Alta Films | false |
| 79 | Baaria | - | - | - | $6,402 | 55 | $272,207 | May 21 | TriPictures | false |
| 80 | The Back-up Plan | - | - | - | $6,154 | 370 | $2,482,690 | May 7 | Sony Pictures Releasing | false |
| 81 | When in Rome | - | - | - | $5,761 | 10 | $41,400 | Jun 18 | Walt Disney Pictures | false |
| 82 | The Maid | - | - | - | $5,699 | 10 | $196,272 | Apr 16 | Golem Distribución | false |
| 83 | Anvil: The Story of Anvil | - | - | - | $5,314 | 4 | $11,868 | Jun 25 | Avalon | false |
| 84 | The Cove | - | - | - | $5,040 | 13 | $44,844 | Jun 11 | - | false |
| 85 | Nanny McPhee Returns | - | - | - | $4,657 | 295 | $3,231,325 | Mar 31 | United International Pictures | false |
| 86 | Hot Tub Time Machine | - | - | - | $4,319 | 240 | $744,973 | May 28 | DeAPlaneta | false |
| 87 | Avatar | - | - | - | $4,065 | 800 | $107,309,094 | Dec 18 | 20th Century Fox International | false |
| 88 | El Regalo 2010 Re-release | - | - | - | $3,952 | 7 | $17,568 | Jun 18 | - | false |
| 89 | Date Night | - | - | - | $3,717 | 340 | $1,077,601 | May 7 | 20th Century Fox International | false |
| 90 | The Bounty Hunter | - | - | - | $3,690 | 344 | $4,053,717 | Apr 9 | Sony Pictures Releasing | false |
| 91 | An Education | - | - | - | $2,834 | 61 | $1,308,337 | Feb 26 | Sony Pictures Releasing | false |
| 92 | Fantastic Mr. Fox | - | - | - | $2,548 | 30 | $136,634 | Apr 23 | 20th Century Fox International | false |
| 93 | My Name Is Khan | - | - | - | $1,734 | 47 | $152,259 | May 28 | 20th Century Fox International | false |
| 94 | The Widows of Thursdays | - | - | - | $1,711 | 85 | $518,952 | Mar 26 | Alta Films | false |
| 95 | Rage | - | - | - | $1,628 | 48 | $145,524 | May 28 | Wanda Visión S.A. | false |
| 96 | Solstorm 2010 Re-release | - | - | - | $971 | 8 | $59,571 | May 21 | Karma Films | false |
| 97 | Extraordinary Measures | - | - | - | $852 | 202 | $881,738 | Mar 12 | Sony Pictures Releasing | false |
| 98 | Familystrip | - | - | - | $697 | 6 | $16,006 | May 28 | - | false |
| 99 | Julie & Julia | - | - | - | $500 | 206 | $2,597,806 | Nov 6 | Sony Pictures Releasing | false |
| 100 | Sorry, If I Love You | - | - | - | $291 | 177 | $1,440,866 | Apr 30 | - | false |
| 101 | Dear John | - | - | - | $258 | 210 | $2,590,323 | Mar 26 | Sony Pictures Releasing | false |
| 102 | The Book of Eli | - | - | - | $218 | 304 | $5,069,500 | Mar 18 | Sony Pictures Releasing | false |
| 103 | Fish Tank | - | - | - | $148 | 35 | $282,878 | Apr 30 | Alta Films | false |
