| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Ice Age: Dawn of the Dinosaurs | - | - | - | $8,775,402 | 112 | $11,644,527 | Jul 3 | 20th Century Fox International | false |
| 2 | Harry Potter and the Half-Blood Prince | - | - | - | $4,034,019 | 120 | $6,610,040 | Jul 15 | Warner Bros. | false |
| 3 | Transformers: Revenge of the Fallen | - | - | - | $2,676,903 | 58 | $4,030,620 | Jun 26 | United International Pictures | false |
| 4 | Up | - | - | - | $2,034,454 | 89 | $7,249,646 | Jun 5 | Walt Disney Pictures | false |
| 5 | The Unborn | - | - | - | $558,999 | 45 | $1,620,599 | Jun 12 | United International Pictures | false |
| 6 | The Last House on the Left | - | - | - | $485,309 | 34 | $558,010 | Jul 10 | United International Pictures | false |
| 7 | Terminator Salvation | - | - | - | $348,889 | 85 | $2,679,579 | Jun 4 | Sony Pictures Releasing | false |
| 8 | Push | - | - | - | $321,757 | 19 | $325,103 | Apr 10 | - | false |
| 9 | 17 Again | - | - | - | $309,289 | 20 | $1,144,367 | Jul 24 | - | false |
| 10 | Night at the Museum: Battle of the Smithsonian | - | - | - | $305,097 | 82 | $4,372,866 | May 22 | 20th Century Fox International | false |
| 11 | Duplicity | - | - | - | $256,571 | 36 | $613,906 | Jun 19 | United International Pictures | false |
| 12 | Transporter 3 | - | - | - | $231,302 | 23 | $516,739 | Jul 24 | - | false |
| 13 | I Love You, Man | - | - | - | $219,453 | 31 | $355,083 | Jul 24 | United International Pictures | false |
| 14 | Angels & Demons | - | - | - | $153,621 | 89 | $4,444,803 | May 15 | Sony Pictures Releasing | false |
| 15 | The Other Boleyn Girl | - | - | - | $143,592 | 18 | $164,515 | Jul 10 | - | false |
| 16 | Impy's Island | - | - | - | $142,576 | 17 | $221,323 | Jun 26 | - | false |
| 17 | El ratón Pérez 2 | - | - | - | $117,718 | 30 | $205,129 | Jul 24 | Walt Disney Pictures | false |
| 18 | War | - | - | - | $100,445 | 20 | $233,319 | Jun 19 | - | false |
| 19 | In Bruges | - | - | - | $95,869 | 10 | $168,442 | Jun 19 | - | false |
| 20 | The Air I Breathe | - | - | - | $71,115 | 9 | $107,013 | Jun 26 | - | false |
| 21 | The Wrestler | - | - | - | $59,129 | 5 | $78,506 | Jul 15 | - | false |
| 22 | Knowing | - | - | - | $35,953 | 41 | $817,528 | May 29 | - | false |
| 23 | Quatre étoiles 2008 Re-release | - | - | - | $32,444 | 3 | $40,147 | Jul 3 | - | false |
| 24 | The Secret Life of Bees | - | - | - | $12,581 | 2 | $30,474 | Jul 24 | 20th Century Fox International | false |
| 25 | Solstice | - | - | - | $9,521 | 15 | $248,308 | May 22 | - | false |
| 26 | Race to Witch Mountain | - | - | - | $8,991 | 40 | $1,838,367 | May 1 | Walt Disney Pictures | false |
| 27 | Traitor | - | - | - | $6,286 | 23 | $135,340 | Jun 12 | - | false |
