| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Half-Blood Prince | - | - | - | $15,383,180 | 890 | $26,965,672 | Jul 15 | Warner Bros. | false |
| 2 | Transformers: Revenge of the Fallen | - | - | - | $4,305,310 | 578 | $11,685,751 | Jun 26 | United International Pictures | false |
| 3 | Ghosts of Girlfriends Past | - | - | - | $1,993,692 | 216 | $2,823,783 | Jul 3 | Warner Bros. | false |
| 4 | The Hangover | - | - | - | $1,941,960 | 292 | $5,950,032 | Jun 19 | Warner Bros. | false |
| 5 | Coraline | - | - | - | $1,475,485 | 205 | $4,957,811 | Jun 19 | United International Pictures | false |
| 6 | Outlander | - | - | - | $1,363,172 | 197 | $1,662,491 | Jul 3 | Eagle Pictures | false |
| 7 | Un'estate ai Caraibi | - | - | - | $772,842 | 545 | $5,311,857 | Jun 12 | Medusa Distribuzione | false |
| 8 | Night at the Museum: Battle of the Smithsonian | - | - | - | $507,905 | 518 | $9,988,389 | May 22 | 20th Century Fox International | false |
| 9 | The Girl with the Dragon Tattoo | - | - | - | $425,612 | 437 | $5,295,520 | May 29 | BIM Distribuzione | false |
| 10 | Angels & Demons | - | - | - | $423,988 | 818 | $26,775,811 | May 13 | Sony Pictures Releasing | false |
| 11 | My Best Friend's Girl | - | - | - | $377,392 | 150 | $1,537,633 | Jun 19 | Eagle Pictures | false |
| 12 | Gran Torino | - | - | - | $328,620 | 332 | $12,993,866 | Mar 13 | Warner Bros. | false |
| 13 | The Boat That Rocked | - | - | - | $328,251 | 99 | $1,383,446 | Jun 12 | United International Pictures | false |
| 14 | Slumdog Millionaire | - | - | - | $212,280 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
| 15 | Monsters vs. Aliens | - | - | - | $207,583 | 496 | $10,546,331 | Apr 3 | United International Pictures | false |
| 16 | Soul Men | - | - | - | $199,065 | 10 | $219,923 | Jul 17 | 01 Distribution | false |
| 17 | Vincere | - | - | - | $198,855 | 302 | $2,991,766 | May 20 | 01 Distribution | false |
| 18 | Under the Same Moon | - | - | - | $194,383 | 10 | $194,383 | Jul 3 | 01 Distribution | false |
| 19 | Notorious | - | - | - | $167,162 | 103 | $209,043 | Jul 17 | 20th Century Fox International | false |
| 20 | Terminator Salvation | - | - | - | $159,600 | 516 | $4,952,079 | Jun 5 | Sony Pictures Releasing | false |
| 21 | The Friends at the Margherita Cafe | - | - | - | $125,605 | 265 | $4,326,733 | Apr 3 | 01 Distribution | false |
| 22 | Anamorph | - | - | - | $117,490 | 11 | $131,277 | Jun 26 | Eagle Pictures | false |
| 23 | St. Trinian's | - | - | - | $111,166 | 141 | $111,166 | Jul 10 | Warner Bros. | false |
| 24 | State of Play | - | - | - | $109,009 | 301 | $3,559,324 | Apr 30 | United International Pictures | false |
| 25 | Journey to the Center of the Earth | - | - | - | $101,247 | 276 | $11,724,131 | Jan 16 | 01 Distribution | false |
| 26 | Ghost Town | - | - | - | $76,405 | 50 | $96,482 | Jul 17 | United International Pictures | false |
| 27 | Crossing Over | - | - | - | $76,386 | 30 | $156,371 | Jun 26 | 01 Distribution | false |
| 28 | Baby Mama | - | - | - | $74,380 | 102 | $117,506 | Jul 24 | United International Pictures | false |
| 29 | Towelhead | - | - | - | $56,867 | 20 | $103,106 | Jul 17 | - | false |
| 30 | Louise hires a contract killer | - | - | - | $54,997 | 48 | $803,171 | Apr 3 | Fandango | false |
| 31 | Obsessed | - | - | - | $48,763 | 12 | $83,546 | Jul 17 | Sony Pictures Releasing | false |
| 32 | My Bloody Valentine | - | - | - | $44,307 | 278 | $8,725,914 | May 8 | Medusa Distribuzione | false |
| 33 | O'Horten | - | - | - | $42,899 | 17 | $106,699 | Jun 19 | - | false |
| 34 | Giovanna's Father | - | - | - | $38,676 | 357 | $4,846,636 | Sep 12 | Medusa Distribuzione | false |
| 35 | The Secret of Moonacre | - | - | - | $33,862 | 176 | $817,253 | Jun 12 | - | false |
| 36 | Coco Before Chanel | - | - | - | $33,295 | 164 | $1,792,873 | May 29 | Warner Bros. | false |
| 37 | Love and Other Crimes | - | - | - | $27,843 | 34 | $114,745 | Jun 19 | - | false |
| 38 | The Great Alibi | - | - | - | $25,526 | 5 | $72,513 | Jun 5 | Medusa Distribuzione | false |
| 39 | Paul Blart: Mall Cop | - | - | - | $25,473 | 14 | $25,473 | Jul 31 | Sony Pictures Releasing | false |
| 40 | Look Both Ways 2009 Re-release | - | - | - | $24,457 | 20 | $96,022 | Jun 19 | Fandango | false |
| 41 | Two Lovers | - | - | - | $23,978 | 108 | $1,339,026 | Mar 27 | BIM Distribuzione | false |
| 42 | Brideshead Revisited | - | - | - | $22,700 | 15 | $71,921 | Jun 26 | Walt Disney Pictures | false |
| 43 | Adventureland | - | - | - | $15,906 | 15 | $31,944 | Jul 10 | Walt Disney Pictures | false |
| 44 | Samsara | - | - | - | $11,554 | 54 | $957,003 | Jun 7 | Fandango | false |
| 45 | Jonas Brothers: The 3D Concert Experience | - | - | - | $9,976 | 15 | $54,974 | Jul 24 | Walt Disney Pictures | false |
| 46 | Filth and Wisdom | - | - | - | $9,167 | 72 | $159,288 | Jun 12 | Sacher Distribuzione | false |
| 47 | Garage | - | - | - | $6,125 | 8 | $98,340 | Jun 5 | - | false |
| 48 | Harry Potter and the Chamber of Secrets | - | - | - | $5,241 | 581 | $29,583,661 | Dec 6 | Warner Bros. | false |
| 49 | Mid-August Lunch | - | - | - | $4,941 | 116 | $3,083,179 | Sep 3 | Fandango | false |
| 50 | I Love You, Beth Cooper | - | - | - | $4,569 | 10 | $4,569 | Jul 10 | 20th Century Fox International | false |
| 51 | Different from Whom | - | - | - | $4,558 | 364 | $4,602,897 | Mar 20 | United International Pictures | false |
| 52 | L'amour | - | - | - | $4,538 | 13 | $115,874 | Jun 5 | - | false |
| 53 | The Reader | - | - | - | $4,528 | 161 | $3,645,596 | Feb 20 | 01 Distribution | false |
| 54 | Cloud 9 | - | - | - | $4,201 | 17 | $145,980 | May 29 | Warner Bros. | false |
| 55 | Frozen River | - | - | - | $4,132 | 20 | $267,882 | Mar 13 | Archibald | false |
| 56 | Borderland | - | - | - | $1,926 | 89 | $238,952 | Jun 19 | Sony Pictures Releasing | false |
