| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Un'estate al mare | - | - | - | $5,289,011 | 576 | $7,770,731 | Jun 27 | Medusa Distribuzione | false |
| 2 | The Dark Knight | - | - | - | $5,113,035 | 616 | $13,871,401 | Jul 23 | Warner Bros. | false |
| 3 | Wanted | - | - | - | $4,721,040 | 393 | $6,197,505 | Jul 2 | Universal Pictures International (UPI) | false |
| 4 | Hellboy II: The Golden Army | - | - | - | $2,840,040 | 345 | $4,722,358 | Jul 16 | Universal Pictures International (UPI) | false |
| 5 | Get Smart | - | - | - | $2,320,328 | 316 | $3,206,939 | Jul 9 | Warner Bros. | false |
| 6 | Funny Games | - | - | - | $1,793,764 | 204 | $2,100,005 | Jul 11 | Lucky Red | false |
| 7 | The Incredible Hulk | - | - | - | $1,767,314 | 477 | $6,460,290 | Jun 18 | Universal Pictures International (UPI) | false |
| 8 | Fist of the North Star: The Legends of the True Savior: Legend of Raoh-Chapter of Death in Love 2008 Re-release | - | - | - | $816,609 | 56 | $26,568 | Jul 4 | Mikado Film | false |
| 9 | The Deaths of Ian Stone | - | - | - | $569,546 | 117 | $644,924 | Jul 18 | Medusa Distribuzione | false |
| 10 | Street Kings | - | - | - | $548,012 | 247 | $898,198 | Jun 27 | 20th Century Fox International | false |
| 11 | Boogeyman 2 | - | - | - | $490,478 | 187 | $490,580 | Jul 4 | Eagle Pictures | false |
| 12 | The Happening | - | - | - | $474,263 | 363 | $3,877,389 | Jun 12 | 20th Century Fox International | false |
| 13 | Gracie | - | - | - | $349,864 | 119 | $703,674 | Jul 18 | Moviemax | false |
| 14 | Go Go Tales | - | - | - | $348,786 | 110 | $849,766 | Jun 20 | Mediafilm | false |
| 15 | Il Divo | - | - | - | $291,080 | 358 | $8,517,653 | May 28 | Lucky Red | false |
| 16 | Made of Honor | - | - | - | $283,231 | 293 | $2,337,688 | Jun 12 | Sony Pictures Releasing | false |
| 17 | Sex and the City | - | - | - | $224,425 | 552 | $9,817,656 | May 30 | 01 Distribution | false |
| 18 | Gomorrah | - | - | - | $181,964 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 19 | Once | - | - | - | $146,254 | 35 | $746,500 | May 30 | Sacher Distribuzione | false |
| 20 | Impy's Island | - | - | - | $118,685 | 131 | $177,467 | Jun 27 | Mediafilm | false |
| 21 | The Year My Parents Went on Vacation | - | - | - | $101,996 | 27 | $384,887 | Jun 6 | Lucky Red | false |
| 22 | Don't Waste Your Time, Johnny! | - | - | - | $95,841 | 64 | $664,266 | Nov 30 | Medusa Distribuzione | false |
| 23 | War | - | - | - | $93,966 | 49 | $100,103 | Jul 18 | 01 Distribution | false |
| 24 | Quiet Chaos | - | - | - | $90,459 | 384 | $9,204,569 | Feb 8 | 01 Distribution | false |
| 25 | 12 | - | - | - | $88,047 | 16 | $134,299 | Jun 27 | 01 Distribution | false |
| 26 | Into the Wild | - | - | - | $84,595 | 191 | $8,058,998 | Jan 25 | BIM Distribuzione | false |
| 27 | The Rest of the Night 2008 Re-release | - | - | - | $78,789 | 61 | $282,009 | Jun 11 | 01 Distribution | false |
| 28 | The Darjeeling Limited | - | - | - | $58,827 | 70 | $1,237,762 | Apr 30 | 20th Century Fox International | false |
| 29 | Il peso dell'aria | - | - | - | $55,057 | 5 | $57,119 | Jul 2 | Poker Film | false |
| 30 | Things We Lost in the Fire | - | - | - | $53,125 | 97 | $414,156 | Jun 12 | Teodora Film | false |
| 31 | Tutta la vita davanti | - | - | - | $52,625 | 368 | $5,648,340 | Mar 28 | Medusa Distribuzione | false |
| 32 | P2 | - | - | - | $51,125 | 24 | $144,854 | Jul 25 | Eagle Pictures | false |
| 33 | Man About Town | - | - | - | $44,230 | 51 | $44,230 | Jul 4 | Warner Bros. | false |
| 34 | Ho ammazzato Berlusconi | - | - | - | $43,140 | 4 | $77,794 | Jun 20 | Independent Films | false |
| 35 | Non pensarci | - | - | - | $38,948 | 222 | $2,239,655 | Apr 4 | 01 Distribution | false |
| 36 | Irina Palm | - | - | - | $35,080 | 54 | $2,612,727 | Dec 7 | Teodora Film | false |
| 37 | Wild Blood | - | - | - | $34,134 | 215 | $932,866 | May 23 | 01 Distribution | false |
| 38 | The Ruins | - | - | - | $32,339 | 50 | $84,086 | Jun 27 | Universal Pictures International (UPI) | false |
| 39 | In Bruges | - | - | - | $32,310 | 151 | $772,903 | May 16 | Mikado Film | false |
| 40 | Woman's Hearts | - | - | - | $27,750 | 6 | $66,253 | Jun 13 | - | false |
| 41 | Prom Night | - | - | - | $27,070 | 11 | $27,070 | Jul 11 | Sony Pictures Releasing | false |
| 42 | Black House 2008 Re-release | - | - | - | $26,091 | 19 | $41,543 | Jul 25 | Ripley's Film | false |
| 43 | The Other Boleyn Girl | - | - | - | $26,057 | 102 | $2,180,712 | Apr 24 | Universal Pictures International (UPI) | false |
| 44 | The Wind Blows Round | - | - | - | $22,941 | 15 | $659,151 | May 4 | Aranciafilm | false |
| 45 | Joshua | - | - | - | $21,545 | 9 | $28,437 | Jul 11 | 20th Century Fox International | false |
| 46 | Tuttifrutti | - | - | - | $17,850 | 21 | $103,007 | May 16 | - | false |
| 47 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | - | - | - | $17,114 | 8 | $72,993 | Jun 20 | Walt Disney Pictures | false |
| 48 | Elite Squad | - | - | - | $16,854 | 56 | $228,296 | Jun 6 | Mikado Film | false |
| 49 | The Night of the Sunflowers | - | - | - | $16,313 | 11 | $67,192 | Jun 13 | Istituto Luce | false |
| 50 | Alexandra | - | - | - | $11,082 | 7 | $77,404 | May 30 | - | false |
| 51 | Lower City 2008 Re-release | - | - | - | $8,826 | 5 | $8,826 | Jul 4 | - | false |
| 52 | Perfect Creature | - | - | - | $8,701 | 10 | $8,701 | Jul 4 | 20th Century Fox International | false |
| 53 | Savage Grace | - | - | - | $8,675 | 20 | $45,565 | Jun 20 | BIM Distribuzione | false |
| 54 | Dante 01 | - | - | - | $8,106 | 18 | $8,106 | Jul 25 | Warner Bros. | false |
| 55 | Italian Dream | - | - | - | $7,949 | 7 | $17,052 | Jun 27 | Lucky Red | false |
| 56 | College Road Trip | - | - | - | $7,722 | 15 | $7,722 | Jul 18 | Walt Disney Pictures | false |
| 57 | Big City | - | - | - | $5,931 | 18 | $5,931 | Jul 25 | Warner Bros. | false |
| 58 | The Game Plan | - | - | - | $5,595 | 15 | $5,595 | Jul 4 | Walt Disney Pictures | false |
| 59 | The Girl by the Lake | - | - | - | $4,880 | 143 | $4,688,666 | Sep 14 | Medusa Distribuzione | false |
| 60 | Before the Devil Knows You're Dead | - | - | - | $4,487 | 277 | $4,648,889 | Mar 14 | Medusa Distribuzione | false |
| 61 | What Happens in Vegas | - | - | - | $4,074 | 295 | $5,188,588 | May 9 | 20th Century Fox International | false |
| 62 | The Right Distance | - | - | - | $2,858 | 102 | $1,495,120 | Oct 19 | 01 Distribution | false |
| 63 | Dr. Plonk | - | - | - | $2,643 | 4 | $7,792 | Jul 4 | Fandango | false |
| 64 | Be Kind Rewind | - | - | - | $2,564 | 95 | $220,443 | May 23 | BIM Distribuzione | false |
| 65 | Shine a Light | - | - | - | $2,439 | 57 | $479,849 | Apr 11 | BIM Distribuzione | false |
| 66 | Chiamami Salomè | - | - | - | $2,428 | 6 | $57,999 | May 9 | Mediaplex | false |
| 67 | Gravehopping | - | - | - | $2,357 | 2 | $43,057 | Jul 4 | - | false |
| 68 | The Fox and the Child | - | - | - | $2,246 | 240 | $2,400,103 | Mar 21 | Lucky Red | false |
| 69 | 21 | - | - | - | $1,974 | 247 | $3,927,213 | Apr 18 | Sony Pictures Releasing | false |
| 70 | The Diving Bell and the Butterfly | - | - | - | $1,933 | 65 | $750,003 | Feb 15 | BIM Distribuzione | false |
| 71 | Then She Found Me | - | - | - | $1,911 | 142 | $940,111 | Jun 6 | Medusa Distribuzione | false |
| 72 | The Secret of the Grain | - | - | - | $1,727 | 79 | $2,875,013 | Jan 11 | Lucky Red | false |
| 73 | I Am Legend | - | - | - | $1,676 | 506 | $21,020,300 | Jan 11 | Warner Bros. | false |
