| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Fast and the Furious: Tokyo Drift | - | - | - | $3,107,734 | 195 | $4,389,074 | Jul 14 | United International Pictures | false |
| 2 | Silent Hill | - | - | - | $2,959,425 | 304 | $3,530,412 | Jul 7 | Eagle Pictures | false |
| 3 | United 93 | - | - | - | $2,095,810 | 202 | $3,190,330 | Jul 6 | United International Pictures | false |
| 4 | Date Movie | - | - | - | $1,043,323 | 221 | $1,883,254 | Jun 23 | 20th Century Fox International | false |
| 5 | The Lake House | - | - | - | $944,420 | 186 | $1,649,852 | Jun 23 | Warner Bros. | false |
| 6 | The Da Vinci Code | - | - | - | $831,253 | 910 | $39,197,477 | May 19 | Sony Pictures Releasing | false |
| 7 | Vita Smeralda | - | - | - | $630,042 | 113 | $707,659 | Jul 14 | Medusa Distribuzione | false |
| 8 | The Sentinel | - | - | - | $559,923 | 211 | $1,148,607 | Jun 23 | 01 Distribution | false |
| 9 | Volver | - | - | - | $504,263 | 309 | $8,641,208 | May 19 | Warner Bros. | false |
| 10 | Freedomland | - | - | - | $324,258 | 99 | $449,078 | Jul 14 | Sony Pictures Releasing | false |
| 11 | The Eye 3 2006 Re-release | - | - | - | $247,825 | 133 | $247,825 | Jul 21 | Eagle Pictures | false |
| 12 | See No Evil | - | - | - | $244,306 | 146 | $1,023,761 | Jul 28 | Mediafilm | false |
| 13 | Shutter | - | - | - | $243,372 | 129 | $243,372 | Jun 30 | Lucky Red | false |
| 14 | When a Stranger Calls | - | - | - | $239,865 | 125 | $239,865 | Jun 30 | Sony Pictures Releasing | false |
| 15 | Casshern 2006 Re-release | - | - | - | $232,423 | 48 | $282,888 | Jul 14 | Time Code | false |
| 16 | Just My Luck | - | - | - | $215,806 | 38 | $338,776 | Jul 7 | 20th Century Fox International | false |
| 17 | A Prairie Home Companion | - | - | - | $214,263 | 142 | $1,686,150 | Jun 1 | Medusa Distribuzione | false |
| 18 | Notte prima degli esami | - | - | - | $199,254 | 327 | $15,905,030 | Feb 17 | 01 Distribution | false |
| 19 | Bandidas | - | - | - | $188,268 | 101 | $269,740 | Jun 30 | 01 Distribution | false |
| 20 | Mortuary | - | - | - | $156,065 | 176 | $494,672 | Jun 23 | Eagle Pictures | false |
| 21 | Orchestra Seats | - | - | - | $136,582 | 61 | $431,631 | Jun 16 | DNC Entertainment | false |
| 22 | 4-4-2 - Il gioco più bello del mondo | - | - | - | $131,315 | 101 | $452,097 | May 19 | Medusa Distribuzione | false |
| 23 | La cura del gorilla | - | - | - | $126,577 | 154 | $760,249 | Feb 3 | Warner Bros. | false |
| 24 | X-Men: The Last Stand | - | - | - | $101,426 | 463 | $7,401,192 | May 26 | 20th Century Fox International | false |
| 25 | The Devil's Backbone 2006 Re-release | - | - | - | $97,854 | 83 | $97,854 | Jun 30 | Moviemax | false |
| 26 | The Breed | - | - | - | $76,071 | 123 | $512,073 | Jun 2 | Medusa Distribuzione | false |
| 27 | Hoodwinked | - | - | - | $74,758 | 168 | $1,768,995 | Jun 1 | 01 Distribution | false |
| 28 | Shadowboxer | - | - | - | $72,115 | 57 | $72,115 | Jul 21 | Warner Bros. | false |
| 29 | The Fast and the Furious | - | - | - | $37,639 | 9 | $2,851,994 | Sep 21 | United International Pictures | false |
| 30 | Little Manhattan | - | - | - | $20,541 | 24 | $20,541 | Jul 28 | 20th Century Fox International | false |
| 31 | Poseidon | - | - | - | $19,347 | 347 | $3,854,218 | Jun 1 | Warner Bros. | false |
| 32 | Mortadelo & Filemon: The Big Adventure 2006 Re-release | - | - | - | $19,322 | 40 | $19,322 | Jul 14 | Moviemax | false |
| 33 | The Moustache | - | - | - | $18,406 | 22 | $210,359 | Jun 23 | Nexo | false |
| 34 | The Dark | - | - | - | $18,135 | 111 | $128,215 | Jun 23 | Mediafilm | false |
| 35 | Ice Age 2: The Meltdown | - | - | - | $16,933 | 544 | $25,985,050 | Apr 21 | 20th Century Fox International | false |
| 36 | By the Pricking of My Thumbs | - | - | - | $15,578 | 92 | $390,939 | Jun 16 | Medusa Distribuzione | false |
| 37 | Heading South | - | - | - | $8,969 | 47 | $178,561 | Jun 16 | Mikado Film | false |
