| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $857,575 | 18 | $1,917,323 | Dec 17 | 20th Century Fox International | false |
| 2 | Sherlock Holmes | - | - | - | $196,584 | 9 | $261,903 | Jan 7 | Warner Bros. | false |
| 3 | It's Complicated | - | - | - | $169,370 | 8 | $299,517 | Dec 24 | United International Pictures | false |
| 4 | Planet 51 | - | - | - | $121,498 | 10 | $179,710 | Dec 31 | - | false |
| 5 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $107,825 | 13 | $576,300 | Jan 28 | 20th Century Fox International | false |
| 6 | Up in the Air | - | - | - | $77,750 | 5 | $125,379 | Jan 14 | United International Pictures | false |
| 7 | The Flight Before Christmas | - | - | - | $64,109 | 8 | $451,221 | Dec 3 | - | false |
| 8 | Old Dogs | - | - | - | $53,276 | 6 | $157,569 | Dec 10 | Walt Disney Pictures | false |
| 9 | The Book of Eli | - | - | - | $47,814 | 6 | $90,552 | Jan 21 | - | false |
| 10 | The Princess and the Frog | - | - | - | $46,170 | 9 | $115,260 | Jan 21 | Walt Disney Pictures | false |
| 11 | Love Happens | - | - | - | $23,885 | 5 | $81,650 | Dec 10 | - | false |
| 12 | Paranormal Activity | - | - | - | $19,082 | 6 | $124,623 | Dec 10 | - | false |
| 13 | Daybreakers | - | - | - | $18,937 | 4 | $20,803 | Jan 14 | - | false |
| 14 | The Men Who Stare at Goats | - | - | - | $15,973 | 4 | $74,580 | Jan 28 | - | false |
| 15 | Capitalism: A Love Story | - | - | - | $10,903 | 1 | $17,906 | Dec 31 | - | false |
| 16 | Coco Chanel & Igor Stravinsky | - | - | - | $10,860 | 1 | $16,790 | Dec 31 | - | false |
| 17 | The Twilight Saga: New Moon | - | - | - | $8,652 | 12 | $386,761 | Nov 26 | - | false |
| 18 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $7,200 | 1 | $11,381 | Jan 14 | - | false |
| 19 | 2012 | - | - | - | $5,982 | 15 | $482,522 | Nov 12 | Sony Pictures Releasing | false |
| 20 | Whip It | - | - | - | $4,866 | 4 | $27,217 | Dec 3 | - | false |
| 21 | Sin Nombre | - | - | - | $4,244 | 1 | $9,309 | Jan 14 | - | false |
| 22 | Broken Embraces | - | - | - | $2,223 | 2 | $57,298 | Nov 26 | - | false |
