| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $19,148,567 | 1,138 | $43,763,643 | Dec 17 | 20th Century Fox International | false |
| 2 | Sherlock Holmes | - | - | - | $10,845,245 | 683 | $11,402,799 | Jan 1 | Warner Bros. | false |
| 3 | Tooth Fairy | - | - | - | $5,574,787 | 500 | $7,890,387 | Jan 15 | 20th Century Fox International | false |
| 4 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $5,507,398 | 768 | $10,208,074 | Dec 25 | 20th Century Fox International | false |
| 5 | Paranormal Activity | - | - | - | $3,470,008 | 362 | $5,940,056 | Dec 25 | Gussi Films | false |
| 6 | Law Abiding Citizen | - | - | - | $1,619,696 | 252 | $2,163,319 | Jan 8 | - | false |
| 7 | The Princess and the Frog | - | - | - | $1,455,703 | 650 | $6,059,800 | Dec 11 | Walt Disney Pictures | false |
| 8 | Up in the Air | - | - | - | $1,361,849 | 251 | $2,176,272 | Jan 22 | Paramount Pictures International | false |
| 9 | The Fourth Kind | - | - | - | $1,285,508 | 225 | $2,577,037 | Jan 22 | Gussi Films | false |
| 10 | Invictus | - | - | - | $1,150,515 | 201 | $2,238,624 | Jan 22 | Warner Bros. | false |
| 11 | Did You Hear About the Morgans? | - | - | - | $1,122,284 | 216 | $1,739,167 | Jan 15 | Sony Pictures Releasing | false |
| 12 | Zombieland | - | - | - | $958,297 | 200 | $1,250,209 | Jan 8 | Sony Pictures Releasing | false |
| 13 | The Book of Eli | - | - | - | $872,625 | 300 | $4,043,777 | Jan 29 | Sony Pictures Releasing | false |
| 14 | All About Steve | - | - | - | $822,768 | 153 | $998,786 | Jan 1 | 20th Century Fox International | false |
| 15 | Everybody's Fine | - | - | - | $790,808 | 150 | $1,424,925 | Dec 25 | Walt Disney Pictures | false |
| 16 | It's Complicated | - | - | - | $755,868 | 350 | $3,497,634 | Jan 29 | Universal Pictures International (UPI) | false |
| 17 | Old Dogs | - | - | - | $635,397 | 370 | $5,066,976 | Nov 27 | Walt Disney Pictures | false |
| 18 | Case 39 | - | - | - | $629,600 | 324 | $3,308,274 | Dec 4 | Paramount Pictures International | false |
| 19 | The Box | - | - | - | $575,115 | 202 | $1,296,123 | Dec 11 | Videocine | false |
| 20 | Labor Pains | - | - | - | $572,318 | 182 | $670,871 | Jan 8 | - | false |
| 21 | The Stepfather | - | - | - | $346,659 | 150 | $586,506 | Dec 11 | Sony Pictures Releasing | false |
| 22 | Mutant Chronicles | - | - | - | $317,594 | 130 | $405,465 | Jan 8 | Videocine | false |
| 23 | Nikté | - | - | - | $270,488 | 413 | $1,329,775 | Dec 17 | Universal Pictures International (UPI) | false |
| 24 | Ninja Assassin | - | - | - | $253,596 | 120 | $430,480 | Jan 15 | Warner Bros. | false |
| 25 | The Twilight Saga: New Moon | - | - | - | $251,059 | 838 | $18,808,309 | Nov 19 | - | false |
| 26 | Astro Boy | - | - | - | $245,340 | 149 | $710,349 | Jan 29 | - | false |
| 27 | Fame | - | - | - | $229,711 | 151 | $275,939 | Jan 15 | - | false |
| 28 | 2012 | - | - | - | $224,866 | 780 | $19,423,924 | Nov 13 | Sony Pictures Releasing | false |
| 29 | Regresa | - | - | - | $204,084 | 230 | $1,396,505 | Jan 22 | - | false |
| 30 | Pandorum | - | - | - | $182,109 | 100 | $285,967 | Jan 15 | Gussi Films | false |
| 31 | New York, I Love You | - | - | - | $117,869 | 39 | $362,806 | Dec 17 | - | false |
| 32 | Julie & Julia | - | - | - | $83,799 | 40 | $594,723 | Oct 23 | Sony Pictures Releasing | false |
| 33 | Planet 51 | - | - | - | $77,972 | 452 | $4,590,034 | Nov 27 | Videocine | false |
| 34 | AAA, la película: Sin límite en el tiempo | - | - | - | $74,712 | 226 | $557,931 | Jan 22 | Videocine | false |
| 35 | Motherhood | - | - | - | $48,753 | 40 | $188,480 | Jan 29 | Gussi Films | false |
| 36 | Opium: Diary of a Madwoman | - | - | - | $43,547 | 9 | $59,534 | Jan 8 | - | false |
| 37 | The Milk of Sorrow | - | - | - | $35,485 | 10 | $52,630 | Jan 15 | - | false |
| 38 | Departures | - | - | - | $31,458 | 20 | $159,238 | Jan 29 | - | false |
| 39 | A Serious Man | - | - | - | $29,797 | 15 | $137,186 | Jan 29 | Universal Pictures International (UPI) | false |
| 40 | Lemon Tree | - | - | - | $28,786 | 11 | $52,284 | Dec 25 | - | false |
| 41 | Paris | - | - | - | $21,558 | 30 | $72,137 | Dec 11 | - | false |
| 42 | Easy Virtue | - | - | - | $18,236 | 10 | $87,402 | Dec 4 | Sony Pictures Releasing | false |
| 43 | The Haunting | - | - | - | $9,863 | 100 | $344,079 | Nov 19 | - | false |
| 44 | Broken Embraces | - | - | - | $4,958 | 75 | $440,012 | Nov 13 | Universal Pictures International (UPI) | false |
| 45 | Away We Go | - | - | - | $3,834 | 14 | $74,986 | Nov 19 | Universal Pictures International (UPI) | false |
| 46 | Love on a Weekend | - | - | - | $3,693 | 40 | $30,615 | Jan 22 | - | false |
| 47 | Taking Woodstock | - | - | - | $1,884 | 8 | $30,530 | Dec 4 | Universal Pictures International (UPI) | false |
| 48 | Fireflies in the Garden 2008 Re-release | - | - | - | $1,738 | 95 | $181,546 | Nov 13 | - | false |
| 49 | Film Noir 2009 Re-release | - | - | - | $744 | 2 | $5,604 | Dec 11 | - | false |
| 50 | Year One | - | - | - | $640 | 150 | $1,097,413 | Oct 9 | Sony Pictures Releasing | false |
| 51 | Fados | - | - | - | $635 | 1 | $4,785 | Dec 4 | - | false |
| 52 | The Limits of Control | - | - | - | $310 | 2 | $6,279 | Dec 11 | Universal Pictures International (UPI) | false |
| 53 | 100 Feet | - | - | - | $82 | 50 | $83,954 | Nov 13 | - | false |
